Long-term changes in multimodal intensive tinnitus therapy

Brüggemann, Petra; Otto, Josephine; Lorenz, Norbert; Schorsch, S.; Szczepek, Agnieszka J.; Böcking, B; Mazurek, Birgit

doi:10.1007/s00106-017-0463-4

Cited by 15 publications

(12 citation statements)

References 34 publications

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“…In Seydel et al (2010), more improvement was noticed in participants with higher level of stress. The improvement in TQ and PSQ scores were maintained 5 years post-multimodal TRT (Brüggemann et al, 2018).…”

Section: Change In Tinnitus and Stress After Interventionmentioning

confidence: 82%

“…<Table 4>Cognitive Behavioural Therapy (CBT) was used in four interventional studies. CBT was part of a multimodal treatment inBrüggemann et al (2018) who reported improvement in TQ and PSQ after 7 days of multimodal treatment and this improvement was maintained in 5 years follow-up. InHesser et al (2012) THI and PSS scores improved after internet-delivered CBT and Acceptance and Commitment Therapy (ACT); there was a significant linear decrease in tinnitus distress and PSS scores.Li et al (…”

mentioning

confidence: 99%

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Tinnitus and stress in adults: a scoping review

Elarbed

Fackrell

Baguley

et al. 2020

International Journal of Audiology

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Section: Change In Tinnitus and Stress After Interventionmentioning

confidence: 82%

mentioning

confidence: 99%

Tinnitus and stress in adults: a scoping review

Elarbed

Fackrell

Baguley

et al. 2020

International Journal of Audiology

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“…Cognitive-behavioral approaches have been shown to be effective in the treatment of chronic tinnitus [8,[11][12][13]. Amongst these, a multimodal tinnitusspecific therapy program has been shown to be effective at 3 and 5-year follow up [14]. Upon presenting at an outpatient clinic, tinnitus patients, including patients suffering from chronic tinnitus who provided the data used in the study, undergo comprehensive medical and psychological assessments that inform individual case conceptualizations and treatment planning.…”

Section: Methodsmentioning

confidence: 99%

Tinnitus-related distress after multimodal treatment can be characterized using a key subset of baseline variables

et al. 2020

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BackgroundChronic tinnitus is a complex condition that can be associated with considerable distress. Whilst cognitive-behavioral treatment (CBT) approaches have been shown to be effective, not all patients benefit from psychological or psychologically anchored multimodal therapies. Determinants of tinnitus-related distress thus provide valuable information about tinnitus characterization and therapy planning. OPEN ACCESS Citation: Niemann U, Boecking B, Brueggemann P, Mebus W, Mazurek B, Spiliopoulou M (2020) Tinnitus-related distress after multimodal treatment can be characterized using a key subset of baseline variables. PLoS ONE 15(1): e0228037. https://doi. ResultsThe best machine learning classifier (gradient boosted trees) can predict tinnitus-related distress in T1 with AUC = 0.890 using 26 features. Subjectively perceived tinnitus-related impairment, depressivity, sleep problems, physical health-related impairments in quality of life, time spent to complete questionnaires and educational level exhibited a high attribution towards model prediction. ConclusionsMachine learning can reliably identify baseline features recorded prior to treatment commencement that characterize tinnitus-related distress after treatment. The identification of key features can contribute to an improved understanding of multifactorial contributors to tinnitus-related distress and thereon based multimodal treatment strategies.Tinnitus-related distress after treatment can be characterized using only few baseline variables PLOS ONE | https://doi.

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“…At best, tinnitus treatments should integrate all involved components/ systems [ 27 ]; hence, a combination of different therapeutic approaches could provide further remedy. Studies focusing on combinatory interventions range from combinations of hearing aids with sound generators [ 28 – 30 ], simultaneous sound and somatosensory stimulations [ 31 , 32 ], application of counseling together with tinnitus masking termed tinnitus retraining therapy [ 13 , 22 , 33 , 34 ], to brain stimulation in combination with relaxation [ 35 ] as well as multimodal therapies [ 36 , 37 ], though past studies are not capable to provide a clear superiority of combined interventions. A systematic examination of several different single and combinational interventions is currently not available, highlighting the need for more profound investigations in this regard.…”

Section: Introductionmentioning

confidence: 99%

Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial

Schoisswohl

Langguth

Schecklmann

et al. 2021

Trials

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Background Tinnitus represents a relatively common condition in the global population accompanied by various comorbidities and severe burden in many cases. Nevertheless, there is currently no general treatment or cure, presumable due to the heterogeneity of tinnitus with its wide variety of etiologies and tinnitus phenotypes. Hence, most treatment studies merely demonstrated improvement in a subgroup of tinnitus patients. The majority of studies are characterized by small sample sizes, unstandardized treatments and assessments, or applications of interventions targeting only a single organ level. Combinatory treatment approaches, potentially targeting multiple systems as well as treatment personalization, might provide remedy and enhance treatment responses. The aim of the present study is to systematically examine established tinnitus therapies both alone and in combination in a large sample of tinnitus patients. Further, it wants to provide the basis for personalized treatment approaches by evaluating a specific decision support system developed as part of an EU-funded collaborative project (Unification of treatments and interventions for tinnitus patients; UNITI project). Methods/study design This is a multi-center parallel-arm randomized clinical trial conducted at five different clinical sites over the EU. The effect of four different tinnitus therapy approaches (sound therapy, structured counseling, hearing aids, cognitive behavioral therapy) applied over a time period of 12 weeks as a single or rather a combinatory treatment in a total number of 500 chronic tinnitus patients will be investigated. Assessments and interventions are harmonized over the involved clinical sites. The primary outcome measure focuses on the domain tinnitus distress assessed via the Tinnitus Handicap Inventory. Discussion Results and conclusions from the current study might not only provide an essential contribution to combinatory and personalized treatment approaches in tinnitus but could also provide more profound insights in the heterogeneity of tinnitus, representing an important step towards a cure for tinnitus. Trial registration ClinicalTrials.gov NCT04663828. Registered on 11 December 2020.

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Long-term changes in multimodal intensive tinnitus therapy

Abstract: The results of the present study support the effectiveness of the 7‑day multimodal intensive therapy for tinnitus. Posttreatment improvements were related to both tinnitus burden as well as stress and depressive symptoms and were maintained at the 5‑year follow-up.

Cited by 15 publications

References 34 publications

Tinnitus and stress in adults: a scoping review

Tinnitus and stress in adults: a scoping review

Tinnitus-related distress after multimodal treatment can be characterized using a key subset of baseline variables

Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial

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