Long‐term commercial cow's milk consumption and its effects on metabolic parameters associated with obesity in young mice

Abstract

Whole-milk consumption leads to increased body weight and caloric intake and reduced insulin signaling in WAT, as opposed to low-fat milk consumption.

Meta-Analysis of Milk Consumption and the Risk of Cognitive Disorders

“…Milk intake may reduce the risk of cognitive impairment via modifying neurovascular dysfunction, reducing weight and metabolic risks [32,33]. Animal studies also reported the effect of dairy products in anti-obesity [34,35]. Although no evidence from randomized controlled trials has investigated the preventive effect of milk consumption on cognitive disorders, several trials which showed the protective effect of milk intake against hypertension and obesity might partially support our finding [36,37,38].…”

Adipogenic and insulin resistance- promoting effects of milk consumption

“…In fact, the LF group exhibited a substantial lower liquid consumption and BCAA‐intake compared to the WM group. The lower BCAA‐uptake by the LF group is supported by the measurement of lower BCAA levels in the liver of the LF group animals compared to the hepatic BCAA concentration of mice of the WM group . Accordingly, a higher BCAA‐mediated activation of mTORC1 would explain a higher rate of S6K1 phosphorylation as detected in the liver and WAT of mice of the WM group .…”

“…Serum, liver, and white adipose tissue (WAT) were tested for parameters associated with obesity and insulin signal transduction. The authors clearly demonstrated that whole milk (WM) consumption leads to increased body weight and caloric intake and reduced insulin signaling in WAT . In comparison to the WM group, consumption of low fat (LF) milk resulted in less weight gain and less phosphorylation of the mTORC1 substrate S6K1 indicating reduced mTORC1‐sigaling and attenuated S6K1‐induced insulin resistance (Fig.…”

“…Recently, Yamin et al have reported on the metabolic effects of long‐term cow's milk consumption associated with the development of obesity in mice. Newly weaned mice in addition to their regular chow diet received either whole cow's milk (3%), low‐fat cow's (1%) milk, or water as control for 17 weeks.…”

“…Unfortunately, the experimental design of the study of Yamin et al did not control for equal uptakes of BCAA and glutamine between the WM and LF group of mice. In fact, the LF group exhibited a substantial lower liquid consumption and BCAA‐intake compared to the WM group.…”