Long-term consumption of a carbohydrate-restricted diet does not induce deleterious metabolic effects

Grieb, Paweł; Kłapcińska, Barbara; Smol, Ewelina; Pilis, T.; Pilis, Wiesław; Sadowska-Krępa, Ewa; Sobczak, Andrzej; Bartoszewicz, Zbigniew; Nauman, J; Stańczak, K. I.; Langfort, Józef

doi:10.1016/j.nutres.2008.09.011

Cited by 27 publications

(31 citation statements)

References 49 publications

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“…Neither the short nor the long-term consumption of a lowcarbohydrate diet results in deleterious metabolic effects, as evidenced by maintenance of adequate glycemic control and relatively low values for conventional cardiovascular risk factors [42]. In the present work, the use of RD for 7 days did not lead to any biochemical alterations either, except for plasma and urine acetone levels; nevertheless, no patients presented with any symptoms related to ketosis.…”

Section: Discussioncontrasting

confidence: 57%

Short-Term Carbohydrate-Restricted Diet for Weight Loss in Severely Obese Women

et al. 2010

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Section: Discussioncontrasting

confidence: 57%

Short-Term Carbohydrate-Restricted Diet for Weight Loss in Severely Obese Women

et al. 2010

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“…In fact, due to their unique capacity to reduce hunger,34 some patients may find LCHF diets to be more easily sustainable than LFHC diets which require conscious calorie restriction. Importantly, long-term adherence (6 months to >1 year)76 79 to the LCHF has not identified any evidence of harm.…”

Section: Addressing Common Misconceptionsmentioning

confidence: 99%

“…76 78 79 First, the LCHF-induced increase in HDL-C concentrations is considered protective against cardiovascular disease 80. In contrast, LFHC diets do not produce an equivalent HDL-C-raising effect and may in fact cause HDL-C concentrations to fall,72 a potentially detrimental effect.…”

Section: Lchf Diets and Cardiovascular Risk Factorsmentioning

confidence: 99%

“…Similarly, higher blood cholesterol concentrations are not associated with increased mortality after age 60. Given the sometimes dramatic improvements in coronary risk factors on the LCHF diet,39 40 76 79 the fear of ill health effects from the increased (saturated) fat intake on the LCHF diet would appear to be groundless.…”

Section: Addressing Common Misconceptionsmentioning

confidence: 99%

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Evidence that supports the prescription of low-carbohydrate high-fat diets: a narrative review

2017

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Low-carbohydrate high-fat (LCHF) diets are a highly contentious current topic in nutrition. This narrative review aims to provide clinicians with a broad overview of the effects of LCHF diets on body weight, glycaemic control and cardiovascular risk factors while addressing some common concerns and misconceptions. Blood total cholesterol and LDL-cholesterol concentrations show a variable, highly individual response to LCHF diets, and should be monitored in patients adhering to this diet. In contrast, available evidence from clinical and preclinical studies indicates that LCHF diets consistently improve all other markers of cardiovascular risk—lowering elevated blood glucose, insulin, triglyceride, ApoB and saturated fat (especially palmitoleic acid) concentrations, reducing small dense LDL particle numbers, glycated haemoglobin (HbA1c) levels, blood pressure and body weight while increasing low HDL-cholesterol concentrations and reversing non-alcoholic fatty liver disease (NAFLD). This particular combination of favourable modifications to all these risk factors is a benefit unique to LCHF diets. These effects are likely due in part to reduced hunger and decreased ad libitum calorie intake common to low-carbohydrate diets, allied to a reduction in hyperinsulinaemia, and reversal of NAFLD. Although LCHF diets may not be suitable for everyone, available evidence shows this eating plan to be a safe and efficacious dietary option to be considered. LCHF diets may also be particularly beneficial in patients with atherogenic dyslipidaemia, insulin resistance, and the frequently associated NAFLD.

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“…In healthy subjects, cardiovascular factors tend to remain within reference ranges after 3 years (time according to patients’ declarations) of adherence to LChHFD. In most subjects, the ratios of LDL-C/HDL-C and total cholesterol/HDL-C, plasma concentrations of glucose, insulin, glucagon, cortisol, homocysteine, glycerol, and C-reactive protein were normal [163]. Nevertheless, a series of studies have demonstrated that the effects on HDL-C and LDL-C are strongly dependent on the amount of carbohydrate restriction and the intake of saturated fat, and in some cases the LDL-C level may rise despite weight loss [164].…”

Section: Introductionmentioning

confidence: 99%

Low-Carbohydrate Diets: A Matter of Love or Hate

Frigolet¹,

Barragán

Taméz

2011

Ann Nutr Metab

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Low-carbohydrate diets (LChD) have become very popular among the general population. These diets have been used to lose body weight and to ameliorate various abnormalities like diabetes, nonalcoholic fatty liver disease, polycystic ovary syndrome, narcolepsy, epilepsy, and others. Reports suggest that body weight reduction and glycemic control could be attained while following LChD. However, these advantages are more notably found in short periods of time consuming an LChD. Indeed, the safety and efficacy of the latter diets in the long term have not been sufficiently explored. In contrast to what has been proposed, other mentioned pathologies are not improved or are even worsened by carbohydrate restriction. Therefore, the aim of this review is to define the concept of LChD and to explain their clinical effects in the short and long term, their influence on metabolism, and the opinion of nutrition or health authorities. Finally, evincing the research gaps of LChD that are here exposed will later allow us to reach a consensus with regard to their utilization.

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Long-term consumption of a carbohydrate-restricted diet does not induce deleterious metabolic effects

Cited by 27 publications

References 49 publications

Short-Term Carbohydrate-Restricted Diet for Weight Loss in Severely Obese Women

Short-Term Carbohydrate-Restricted Diet for Weight Loss in Severely Obese Women

Evidence that supports the prescription of low-carbohydrate high-fat diets: a narrative review

Low-Carbohydrate Diets: A Matter of Love or Hate

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