Long-term effect of Helicobacter pylori eradication on plasma homocysteine in elderly patients with cobalamin deficiency

Helicobacter pylori and Hematologic Diseases

“…A systematic review and meta-analysis of 17 studies with 2454 patients demonstrated a significant reduction in serum vitamin B 12 levels in patients infected with H. pylori when compared with uninfected persons [128]. Marino et al demonstrated a correlation between the decrease in serum vitamin B 12 levels and the increase in serum homocysteine due to H. pylori infection in 62 older patients: in these same patients, following infection eradication, an increase in serum vitamin B 12 levels and a decrease in serum homocysteine levels occurred until normalization was reached [127].…”

“…Infection with H. pylori can also cause malabsorption of different micronutrients [125] like vitamin B 12 [125][126][127]. A systematic review and meta-analysis of 17 studies with 2454 patients demonstrated a significant reduction in serum vitamin B 12 levels in patients infected with H. pylori when compared with uninfected persons [128].…”

“…With the incorporation of vitamin B 12 deficiency into the consensus and management guides for H. pylori infection as an indication to investigate and eradicate the bacteria [27,29], a new paradigm was generated, where the etiology of vitamin B 12 deficiency can be infectious and the eradication of H. pylori may be sufficient to correct it [127]. Under this new paradigm, where eradication of infection corrects the vitamin B 12 deficiency by a curative rather than palliative treatment [127], the patient is released from a chronic disease [134] closely related to gastric cancer and from diverse diseases such as Alzheimer's disease [107,108], depression [111], stroke [112,113], pulmonary embolism [114], acute myocardial infarction, and coronary heart disease [116], which are regulated through homocysteine and generate high morbidity, mortality, and costs for health systems.…”

The National Program for Optimization of Provision with Vitamins and Minerals of Children in Russia. Summary Review of the Document

“…Так, всасывание витамина В 12 из пищи требует нормального функционирования желудка, поджелудочной железы и тонкой кишки. Однако, основ-ными причинами мальабсорбции витамина B 12 , приво-дящими к развитию B 12 -дефицитной анемии, а также лежащими в основе аутоиммунного состояния, извест-ного как пернициозная анемия, являются хронические воспалительные заболевания желудка [69,70]. Так как жирорастворимые витамины А, D, Е и К усваи-ваются с жирами, возможен дефицит этих витаминов при мальабсорбции жиров любого генеза.…”

The effects of helicobacter pylori infection on nutrition status and metabolism

“…Additionally, H.pylori infection is associated with IDA and after eradication of H.pylori is followed by increasing of serum ferritin and hemoglobin levels in adolescent girls 53 . In a study, evaluated the efects in homocysteine and cobalamin levels after the eradication of H.pylori, was found that eradication therapy associated with increasing of cobalamin levels and decreasing of homocysteine blood levels in elderly patients with cobalamin deficiency 54 . Eradication of H.pylori is effective also in the absorption of vitamin B 12 55 .…”