Long-Term Effects of Early Adolescent Methamphetamine Exposure on Depression-Like Behavior and the Hypothalamic Vasopressin System in Mice

Joca, Lauren K.; Zuloaga, Damian G.; Raber, Jacob; Siegel, Jessica A.

doi:10.1159/000360001

Cited by 28 publications

(41 citation statements)

References 49 publications

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“…Independent of neonatal treatment, females had significantly longer latencies than males to become immobile in the FST after chronic stress exposure, whereas males spent more time immobile in the FST. These dimorphic behaviors are consistent with other models examining the longterm consequences of early-life perturbation [40] . In addition, corticosterone levels during recovery from stress remained significantly elevated, particularly for injured males not given morphine as neonates.…”

Section: Morphine Treatment Rescues Stress Coping Following Chronic Ssupporting

confidence: 90%

Analgesia for Early-Life Pain Prevents Deficits in Adult Anxiety and Stress in Rats

2014

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Previous studies in rats have established that inflammatory pain experienced on the day of birth (P0) decreases sensitivity to acute noxious, anxiety- and stress-provoking stimuli. However, to date, the impact of early-life pain on adult responses to chronic stress is not known. Further, the ability of morphine, administered at the time of injury, to mitigate changes in adult behavioral and hormonal responses to acute or chronic stressors has not been examined. P0 male and female Sprague-Dawley rat pups were given an intraplantar injection of 1% carrageenan or handled in an identical manner in the presence or absence of morphine. As adults, rats that experienced early-life pain displayed decreased sensitivity to acute stressors, as indicated by increased time in the inner area of the Open Field, and increased latency to immobility and decreased time immobile in the Forced Swim Test (FST). An accelerated return of corticosterone to baseline was also observed. Morphine administration at the time of injury completely reversed this ‘hyporesponsive' phenotype. By contrast, following 7 days of chronic variable stress, injured animals displayed a ‘hyperresponsive' phenotype in that they initiated immobility and spent significantly more time immobile in the FST than controls. Responses to chronic stress were also rescued in animals that received morphine at the time of injury. These data suggest that analgesia for early-life pain prevents adult hyposensitivity to acute anxiety- and stress-provoking stimuli and increased vulnerability to chronic stress, and have important clinical implications for the management of pain in infants.

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Section: Morphine Treatment Rescues Stress Coping Following Chronic Ssupporting

confidence: 90%

Analgesia for Early-Life Pain Prevents Deficits in Adult Anxiety and Stress in Rats

2014

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“…Treatment groups consisted of MA (7.5 mg/kg × 4 injections), NIC (0.3 mg/kg × 4 injections), MA and NIC (7.5 mg/kg and 0.3 mg/kg, respectively × 4 injections), and saline (× 4 injections). This injection schedule and paradigm was chosen to replicate previous research examining the effects of early adolescent MA exposure in mice [20, 40] and all solutions were administered via IP injections for consistency between groups. All injections were counterbalanced within the housing cages.…”

Section: Methodsmentioning

confidence: 99%

“…A total of 36 mice (9 per treatment group) underwent behavioral testing in the following order: open field test, novel object recognition test, Porsolt forced swim test, and the Morris water maze on the days indicated below. These specific tests were chosen to replicate previous research examining the effects of adolescent MA exposure [20]. A separate group of 36 mice (9 per treatment group) underwent the same exposure paradigm and were subsequently trained and tested in the CPP test starting on PND 41.…”

Section: Methodsmentioning

confidence: 99%

“…Mice were tested in a brightly lit 40 × 40 cm clear, Plexiglas arena. The interior 20 × 20 cm section of the chamber was designated as the center of the arena [20, 41]. Anymaze Video Tracking Software (Stoelting, Wood Dale, IL, USA) was used to record distance traveled and percent time in the center of the arena during the single ten-minute trial.…”

Section: Methodsmentioning

confidence: 99%

“…MA exposure during adolescence induces long-term impairments in visual discrimination and reversal learning in rats [19]. In mice, MA exposure during early adolescence increases depression-like behavior and decreases vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus [20]. …”

Section: Introductionmentioning

confidence: 99%

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Effects of adolescent methamphetamine and nicotine exposure on behavioral performance and MAP-2 immunoreactivity in the nucleus accumbens of adolescent mice

Buck

Morris

Weber

et al. 2017

Behavioural Brain Research

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The neurotoxic effects of methamphetamine (MA) exposure in the developing and adult brain can lead to behavioral alterations and cognitive deficits in adults. Previous increases in the rates of adolescent MA use necessitate that we understand the behavioral and cognitive effects of MA exposure during adolescence on the adolescent brain. Adolescents using MA exhibit high rates of nicotine (NIC) use, but the effects of concurrent MA and NIC in the adolescent brain have not been examined, and it is unknown if NIC mediates any of the effects of MA in the adolescent. In this study, the long-term effects of a neurotoxic dose of MA with or without NIC exposure during early adolescence (postnatal day 30-31) were examined later in adolescence (postnatal day 41-50) in male C57BL/6J mice. Effects on behavioral performance in the open field, Porsolt forced swim test, and conditioned place preference test, and cognitive performance in the novel object recognition test and Morris water maze were assessed. Additionally, the effects of MA and/or NIC on levels of microtubule associated-2 (MAP-2) protein in the nucleus accumbens and plasma corticosterone were examined. MA and NIC exposure during early adolescence separately decreased anxiety-like behavior in the open field test, which was not seen following co-administration of MA/NIC. There was no significant effect of early adolescent MA and/or NIC exposure on the intensity of MAP-2 immunoreactivity in the nucleus accumbens or on plasma corticosterone levels. These results show that early adolescent MA and NIC exposure separately decrease anxiety-like behavior in the open field, and that concurrent MA and NIC exposure does not induce the same behavioral change as either drug alone.

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The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Baker

Magnuson

Dahly

et al. 2018

Developmental Psychobiology

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Methamphetamine alters behavior and the stress response system. Relatively little research has examined the effects of methamphetamine in adolescents and compared these effects to those in adults. Housing in enriched environments has been explored as one way to protect against the effects of methamphetamine, but the findings are conflicting and no study has examined how enriched environment may alter the behavioral and corticosterone responses to methamphetamine in adolescent and adult rodents. We examined the long-term effects of methamphetamine exposure on anxiety, social behavior, behavioral despair, and corticosterone levels in adolescent and adult mice housed in enriched or isolated environments. Enriched environment did not alter the behavioral or corticosterone response to methamphetamine. Methamphetamine exposure decreased anxiety and increased behavioral despair in adult mice, but methamphetamine did not alter behavior in adolescent mice. There was no effect of methamphetamine on social behavior or corticosterone levels. Our findings demonstrate that the specific environmental enrichment paradigm used in this study was not sufficient to mitigate the behavioral effects of methamphetamine and that adolescent mice are relatively resistant to the effects of methamphetamine compared to adult mice.

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Long-Term Effects of Early Adolescent Methamphetamine Exposure on Depression-Like Behavior and the Hypothalamic Vasopressin System in Mice

Cited by 28 publications

References 49 publications

Analgesia for Early-Life Pain Prevents Deficits in Adult Anxiety and Stress in Rats

Analgesia for Early-Life Pain Prevents Deficits in Adult Anxiety and Stress in Rats

Effects of adolescent methamphetamine and nicotine exposure on behavioral performance and MAP-2 immunoreactivity in the nucleus accumbens of adolescent mice

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

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