Long-term effects of transient cerebellar mutism after cerebellar astrocytoma or medulloblastoma tumor resection in childhood

Huber, Johannes; Bradley, Kim; Spiegler, Brenda J.; Dennis, Maureen

doi:10.1007/s00381-005-1223-4

Cited by 83 publications

(38 citation statements)

References 25 publications

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“…71,105 These children also seemed more dysfluent, speaking at a slower speech rate than children without CM. Huber et al 46 considered that motor speech deficits persist for a long period of time (> 5 years), and similar findings were made by other authors. 52,81,92 Lastly, Robertson et al 82 tried to analyze the neurological outcome of their patients, and they found that there is a significant relationship among the level of initial severity of the syndrome and the severity of ataxia and language dysfunction and global intellectual handicap after 1 year.…”

Section: Outcomesupporting

confidence: 71%

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Cerebellar mutism

Pitsika¹,

Tsitouras²

2013

PED

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Mutism of cerebellar origin is a well-described clinical entity that complicates operations for posterior fossa tumors, especially in children. This review focuses on the current understanding of principal pathophysiological aspects and risk factors, epidemiology, clinical characteristics, treatment strategies, and outcome considerations. The PubMed database was searched using the term cerebellar mutism and relevant definitions to identify publications in the English-language literature. Pertinent publications were selected from the reference lists of the previously identified articles. Over the last few years an increasing number of prospective studies and reviews have provided valuable information regarding the cerebellar mutism syndrome. Importantly, the clarification of principal terminology that surrounds the wide clinical spectrum of the syndrome results in more focused research and more effective identification of this entity. In children who undergo surgery for medulloblastoma the incidence of cerebellar mutism syndrome was reported to be 24%, and significant risk factors so far are brainstem involvement and midline location of the tumor. The dentate-thalamo-cortical tracts and lesions that affect their integrity are considered significant pathophysiological issues, especially the tract that originates in the right cerebellar hemisphere. Moderate and severe forms of the cerebellar mutism syndrome are the most frequent types during the initial presentation, and the overall neurocognitive outcome is not as favorable as thought in the earlier publications. Advanced neuroimaging techniques could contribute to identification of high-risk patients preoperatively and allow for more effective surgical planning that should focus on maximal tumor resection with minimal risk to important neural structures. Properly designed multicenter trials are needed to provide stronger evidence regarding effective prevention of cerebellar mutism and the best therapeutic approaches for such patients with a combination of pharmacological agents and multidisciplinary speech and behavior augmentation.

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Section: Outcomesupporting

confidence: 71%

“…The incidence of CMS has been reported to range from 8% 46 to 39%, 9,15,40,52,55,62,82,108 although there are reviews reporting a lower rate of 1.6%. 17 In the largest prospective study so far of 450 children who underwent surgery for medulloblastomas, the incidence of CMS was found to be 24%.…”

Section: Incidencementioning

confidence: 99%

Cerebellar mutism

Pitsika¹,

Tsitouras²

2013

PED

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“…They have speech deficits such as dysfluency, ataxic dysarthria, and slow speech rate (Huber-Okrainec et al, 2002) similar to those seen after acquired lesions of the cerebellum (Ackermann & Hertrich, 2000;Brown et al, 1970;Darley et al, 1969aDarley et al, , 1969bHuber et al, 2006Huber et al, , 2007Riva & Giorgi, 2000).…”

Section: Introductionmentioning

confidence: 90%

Verb generation in children with spina bifida

Dennis

Jewell

Hetherington

et al. 2008

J. Inter. Neuropsych. Soc.

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We investigated verb generation in children with spina bifida meningomyelocele (SBM; n 5 55) and in typically developing controls (n 5 32). Participants completed 6 blocks (40 trials each) of a task requiring them to produce a semantically related verb in response to a target noun and an additional 40 trials on which they were simply required to read target nouns aloud. After controlling for reading response time, groups did not differ significantly in verb generation response time or learning. Children with SBM produced more non-verb errors than controls and tended to repeat their mistakes over blocks. Verb generation performance was associated with brain volume measures in participants with SBM. Congenital cerebellar dysmorphology is associated with impaired performance in verb generation accuracy, although not with increased response times to produce verbs. (JINS, 2008, 14, 181-191.)

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“…El primero en describirlo fue Rekate en 1985 2 ; principalmente como un déficit postoperatorio en cirugías de fosa posterior 3,4 , aunque también se ha descrito secundario a infecciones [5][6][7][8] , trauma 9,10 o eventos isquémicos [11][12][13] . Es una complicación relativamente común después de una cirugía de fosa posterior (se ha descrito una incidencia entre el 11 y el 29% de los casos) 4,14,15 aunque su verdadera incidencia es difícil de determinar debido a problemas en la terminología y una definición variable del síndrome 16 . En la literatura existe una considerable superposición entre los términos "síndrome de fosa posterior", "mutismo cerebeloso", "mutismo acinético" y "mutismo con disartria posterior".…”

Section: Introductionunclassified

Tractografía de la vía dento-rubro-talámica en mutismo cerebeloso postoperatorio en niños con tumores de fosa posterior

Cohen-Scheihing

2015

Rev. chil. neuro-psiquiatr.

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Long-term effects of transient cerebellar mutism after cerebellar astrocytoma or medulloblastoma tumor resection in childhood

Abstract: Survivors who had TCM showed more speech deficits than controls or survivors without TCM. The data suggest that speech deficits are chronic if not permanent sequelae of TCM.

Cited by 83 publications

References 25 publications

Cerebellar mutism

Cerebellar mutism

Verb generation in children with spina bifida

Tractografía de la vía dento-rubro-talámica en mutismo cerebeloso postoperatorio en niños con tumores de fosa posterior

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