Long-term efficacy and safety of botulinum toxin type A (Dysport) in cervical dystonia

Primary results from the Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy (CD PROBE)

“…Baseline demographics of subjects were similar to those of subjects in other large trials [8,[21][22][23][24][25]. Baseline TWSTRS Total scores were slightly lower in CD PROBE compared with those from registration trials for other BoNTs (mean of 39.2 in CD PROBE and low to mid-40s for registration trials) [21][22][23][24].…”

“…Registries also do not provide study drug, and so are limited by reimbursement and other financial challenges that may adversely impact retention. In comparison to CD PROBE's retention rate (48.0% of subjects completed the study), 72-96% of subjects in the BoNT registration trials completed the respective studies [8,[21][22][23][24], with the exception of 1 trial in which 26.3% of subjects remained in the study after week 12 [25]. The retention rate in CD PROBE was lower than those of other registries, which range from 65.4 to 77.5% [28,29].…”

“…Baseline TWSTRS Total scores were slightly lower in CD PROBE compared with those from registration trials for other BoNTs (mean of 39.2 in CD PROBE and low to mid-40s for registration trials) [21][22][23][24].…”

Dystonias of the Neck: Clinico-Radiologic Correlations

“…Response rates of approximately 80% have been achieved in patients with CD in open and double-blind studies [9][10][11] . Furthermore, treatment is generally well tolerated even following long-term administration 12,13 and the risk of adverse events may also be minimized using well-defined injection procedures.…”

How Effective and Safe is Botulinum Toxin Therapy in Cervical Dystonia: The Current Stand

“…However, in another study, it was mentioned that the dysphagia did not appear to be dose-or treatment cycle-related [53].…”