Long-term exposure to high air pollution induces cumulative DNA damages in traffic policemen

Tan, Chongqing; Shan, Lu; Wang, Yupeng; Zhu, Yan; Shi, Ting; Lin, Mingyue; Deng, Zhonghua; Wang, Zhu; Song, Nana; Li, Shuna; Yang, Peng; Yang, Liyan; Liu, Yuanyuan; Chen, Zhiheng; Xu, Ke

doi:10.1016/j.scitotenv.2017.03.179

Cited by 42 publications

(23 citation statements)

References 44 publications

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“…It was also reported that airborne particles induce important changes in the expression of pro-inflammatory cytokines and psoriatic skin disease-related genes, leading to potential dysfunction of the human epidermis (Kim et al, 2017). Chronic exposures to air pollutants would also increase DNA damages and cancer risks in traffic policemen (Tan et al, 2017) and would reduce life expectancy (Dziubanek et al, 2017) particularly among tuberculosis patients (Peng et al, 2017). Scaling down greenhouse emissions and improving air quality by reducing air pollutions could thus ameliorate the public health and save important medication costs while enhancing benefit-cost ratios (Simons et al, 2016) (Pascal et al, 2013) (Lu et al, 2016) (Gao et al, 2016).…”

Section: Effects Of Climate Change and Air Pollutionmentioning

confidence: 99%

A clean environmental week: Let the nature breathe

Moustafa

2017

Science of The Total Environment

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High levels of CO emissions in the atmosphere and toxic pollutants in air, water and food have serious repercussions on all life's systems, including living beings, environment and economy. Everyone on the Earth is concerned by pollution in some way or another, no matter where and how the pollution is produced as airborne and foodborne pollutants could circulate around the world in different ways, through for example climate components (wind, rain) and/or import and export of foodstuffs. Similarly to living beings that take advantage of day-night circadian rhythms to recover after diurnal hardships, the environment in its entirety could also be seen as a complex living system that needs regular breaks to assimilate or ingest toxic pollutants produced during intensive and continuous industrial processes. If greenhouses gas emissions and pollution rates continue to increase at the same rates as they are nowadays, uncontrollable climate effects might be inevitable and the air quality in some crowded cities in the world might be hardly respirable in the future. A global "Clean Environmental Week" is discussed as an attempt toward reducing air pollution and CO emissions through the interruption or reduction of industrial polluting activities regularly, for a week or so per year, to let the nature 'breathe' and recover from environmentally challenging pollutions. A clean environmental period of 10 days per year could reduce CO emissions by about one billion tons of CO per annum.

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Section: Effects Of Climate Change and Air Pollutionmentioning

confidence: 99%

A clean environmental week: Let the nature breathe

Moustafa

2017

Science of The Total Environment

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“…Particularly, for the third-world countries, the energy structure is not reasonable, and coal is as the main types of fuel [41,40]. Hence, the atmospheric environment pollution has been paid more attention [38]. Moreover, the repairable particulate matter, carbon monoxide, sulfur dioxide, nitrogen oxides in the air have speeded up the air pollution.…”

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confidence: 99%

“…Construct the evaluation factor U = {u 1 , u 2 , • • • , u m } and the remark set Based on the theory of the APH model, we propose a hybrid AHP-Fuzzy Comprehensive Evaluation Model to assess the atmospheric environmental quality [35] [36]. In the proposed hybrid model, AHP is able to estimate the weight coefficient of the index system, and fuzzy comprehensive evaluation [37] [38] approach can tackle the vagueness of remark in evaluation process. Firstly, we build a hierarchical evaluation index system by AHP, and then compute the weight for each layer indicator.…”

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confidence: 99%

Atmospheric environmental quality assessment method based on analytic hierarchy process

Lv¹,

Ji²

2019

Discrete &Amp; Continuous Dynamical Systems - S

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Atmospheric environmental quality significantly influences the environment of people's life and the development of modern society. Therefore, in this paper, we aim to accurately assess atmospheric environmental quality. Firstly, we propose and analyze two indicator systems for atmospheric environmental quality assessment, that is, 1) the standard air pollution index, and 2) an index system which covers different types of influencing factors related to air quality. In particular, the proposed index system is made up of seven parts, that is, 1) Climate and meteorology, 2) Economic and social development, 3) Industrial structure, 4) Energy consumption, 5) Industrial pollutant discharge, 6) The greening of the city, and 7) Environmental protection construction. Secondly, we propose a hybrid AHP-Fuzzy Comprehensive Evaluation Model to evaluate the atmospheric environmental quality. In the hybrid model, AHP is used to calculate the weight coefficient of the index system, and fuzzy comprehensive evaluation model is exploited to describe the vagueness of remark in the evaluation process. Finally, experimental results demonstrate that using the proposed index system, the hybrid AHP-Fuzzy comprehensive evaluation model is able to assess air quality more accurately than the modified API.

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“…O aumento do IQR na média móvel de PM2,5 7 dias após exposição esteve associado ao aumento do risco de: leucocitúria (3,4; 95% IC 2,6: 4,3); positividade de anti-dsDNA ( As partículas finas e ultrafinas podem passar do alvéolo para a circulação sistêmica e desencadear uma resposta de estresse oxidativo com liberação de fatores pró-trombóticos e citocinas inflamatórias gerando inflamação sistêmica 34,36,37 . Além disso, estudos têm demonstrado a associação entre a inalação de PM2,5 e dano cumulativo ao DNA 38 e aumento dos níveis séricos de biomarcadores inflamatórios [39][40][41][42][43] .…”

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Influência da poluição do ar sobre a atividade renal nos pacientes com lúpus eritematoso sistêmico juvenil

Goulart¹

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Goulart MFG. Influence of air pollution on renal activity of juvenile systemic lupus erythematosus patients [thesis]. São Paulo: "Faculdade de Medicina, Universidade de São Paulo"; 2019.Childhood-systemic lupus erythematosus (cSLE) is an inflammatory chronic, autoimmune and multifactorial disease that can affect different organs and systems. Exposure to air pollution can trigger systemic inflammation in cSLE patients and increase the risk of disease activity. Objective: To evaluate the effect of individual exposure to air pollutants on renal activity by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) in cSLE patients. Methodology: A longitudinal panel study was carried out in 108 consecutive medical appointments with nine cSLE patients. Over a period of three consecutive weeks, individual levels of nitrogen dioxide (NO2), fine particulate matter (PM2.5) as well as temperature and humidity were measured daily. Each three-week cycle was repeated every two months and half over a period of one year and clinical evaluation and laboratory tests for SLEDAI-2K evaluation were performed weekly. Specific generalized estimation equation models were used to assess the impact of these pollutants on the risk of disease activity (SLEDAI-2K≥8), nephritis and anti-dsDNA positive levels. We also evaluated continuous variables: 24-hour urine protein and serum complement (C3) levels. Models were adjusted for inflammatory indicators, body mass index, infections, medications and weather variables. Results: An interquartile range (IQR) increase of 18.12µg/m3 in PM2.5 daily concentration was associated with an increased risk of: nephritis, anti-dsDNA positive levels and SLEDAI-2K≥8. Moreover, an increase in 24-hour urine protein and a decrease in serum C3 levels were observed. An IQR increase in PM2.5 7-day moving average was associated with an increased risk of leukocyturia (3.4 95%IC:2.6-4.3), anti-dsDNA positive levels (3.1; 95%CI:2.1-4.0) and SLEDAI≥8 (1.5; 95%CI:1.1-1.8). In addition, a 36.3 mg increase (95%IC:20.2-52.3) in 24-hour urine protein levels as well as a 1,9 mg/ dl (95% IC -0,06: -3,8) decrease in C3 levels. An IQR increase (63.1µg/m3) in 7-day cumulative NO2 levels was associated with an increased risk of SLEDAI ≥ 8 (2.6; 95%CI: 1.9-3.3) and a 6.4 mg/ dl (IC95%: -10,9: -1,9) decrease in C3 levels. Conclusion: This prospective study suggests that exposure to air pollution can trigger renal activity in cSLE patients.

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Long-term exposure to high air pollution induces cumulative DNA damages in traffic policemen

Cited by 42 publications

References 44 publications

A clean environmental week: Let the nature breathe

A clean environmental week: Let the nature breathe

Atmospheric environmental quality assessment method based on analytic hierarchy process

Influência da poluição do ar sobre a atividade renal nos pacientes com lúpus eritematoso sistêmico juvenil

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