Long-Term Impact of Diabetes and Its Comorbidities in Patients Undergoing Isolated Primary Coronary Artery Bypass Graft Surgery

Abstract

Background— The objective of this study was to identify the impact of diabetes and related comorbidities, namely chronic renal failure, peripheral vascular disease, and low ejection fraction (<35%), on long-term survival of patients undergoing coronary artery bypass graft surgery. Methods and Results— A unicenter study was conducted on 9125 survivors of isolated coronary artery bypass graft surgery between 1992 and 2002. There were 6581 nondiabetic patients and 2544 diabetics, including 1809 patients with noninsulin-dependent diabetes mellitus and 735 patients with insulin-dependent diabetes mellitus. Cardiac-specific survival at 5 and 10 years was lower in insulin-dependent diabetes mellitus compared with both nondiabetic mellitus patients and patients with noninsulin-dependent diabetes mellitus ( P <0.0001). However, freedom from cardiac-related death was similar for patients with noninsulin-dependent diabetes mellitus and nondiabetes mellitus patients up to 6 years ( P =0 0.08) after surgery and was significantly lower thereafter ( P =0.004). Cardiac-specific survival after coronary artery bypass graft surgery in patients with one or more comorbidities was comparable ( P =0.4) for both nondiabetes mellitus patients and patients with noninsulin-dependent diabetes mellitus, but was significantly lower for those requiring insulin therapy ( P <0.0001). Noninsulin-dependent diabetes mellitus was not an independent predictor of long-term cardiac death (hazard ratio: 1.09, P =0.41); however, insulin-dependent diabetes mellitus, chronic renal failure, peripheral vascular disease, and low ejection fraction were all independent risk factors for late cardiac death (all P <0.0001). The impact of comorbidities on the long-term risk of cardiac death was similar for the 3 groups. Conclusions— Noninsulin-dependent diabetes is not an independent predictor of late cardiac death after coronary artery bypass graft surgery, because cardiac-related survival is similar to that of nondiabetic patients for 6 years after surgery. In diabetic and nondiabetic patients, cardiac survival is adversely affected by the need for insulin therapy and/or the presence and number of comorbidities such as chronic renal failure, peripheral vascular disease, and low ejection fraction.

Diabetes Mellitus and Prevention of Late Myocardial Infarction After Coronary Stenting in the Randomized Dual Antiplatelet Therapy Study

“…1,2 Moreover, patients with DM experience poorer outcomes from these events, including a greater risk of death or recurrent myocardial infarction (MI). 3,4 Among patients undergoing coronary stenting, patients with DM also have a higher risk for stent thrombosis. 5 Part of the effect of DM may be explained by the contribution of insulin resistance and hyperglycemia to a prothrombotic state including direct effects on platelet function, both adhesion and aggregation, resulting in hyperreactivity.…”

Impact of Perioperative Glycemic Control Strategy on Patient Survival After Coronary Bypass Surgery

“…Although recent literature has shown that perioperative survival is improved with glycemic control (whether tight or liberal) long-term data are scarce [14,15,[23][24][25][26][27][28][29][30][31]. Diabetic patients with coronary artery disease reputedly have worse long-term outcomes than nondiabetic patients [15].…”

Mesenteric endothelial dysfunction in a cardiopulmonary bypass rat model: The effect of diabetes

“…[8][9][10][11][12][13] The diabetic population represents more than 38% of patients undergoing cardiac surgery procedures, especially coronary revascularisation. 14 It has been assumed that the greater surgical risk associated with diabetes mellitus might be a consequence of an altered inflammatory response to CPB, 15 which is characterised by increased secretion of cytokines (interleukin-6 [IL-6]) and tumour necrosis factor-alpha (TNF-α), oxidative stress 16,17 and endothelial dysfunction, 8,18 especially in the mesenteric vasculature.…”