Long-Term Improvement in Aortic Pulse Wave Velocity After Weight Loss Can Be Predicted by White Adipose Tissue Factors

Bäckdahl, Jesper; Andersson, Daniel P.; Eriksson-Hogling, Daniel; Caidahl, Kenneth; Thorell, Anders; Mileti, Enrichetta; Daub, Carsten O.; Arner, Peter

doi:10.1093/ajh/hpx201

Cited by 13 publications

(5 citation statements)

References 53 publications

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“…Similar to our results, Arner et al [52] demonstrated that PWVAo correlated positively with subcutaneous adipocyte volume and negatively with fat cell count in patients with obesity. Weight loss could be associated with improvement in PWVAo but positive long-term results on arterial stiffness can only be achieved by bariatric surgery [53]. Regarding blood vessel wall thickness, no significant correlations with parameters of arterial stiffness were reported in our study.…”

Section: Discussioncontrasting

confidence: 63%

Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity

Onofrei

Anisie

Zamfir

et al. 2023

JCM

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Background and objective: The development of arterial stiffness (AS) in obesity is a multifactorial and complex process. The pleomorphic actions of adipokines and their local activity in perivascular adipose tissue (PVAT) are potential modulators of AS appearance and progression. We aimed to assess the correlations between two adipokines (chemerin, adiponectin), PVAT morphological changes (adipocyte size, blood vessel wall thickness) and AS parameters in the special subgroup of patients with morbid obesity. Material and methods: We enrolled 25 patients with morbid obesity and 25 non-obese patients, who were age- and gender-matched, untreated for cardiovascular risk factors, and admitted to hospital for laparoscopic surgical procedures (bariatric surgery for morbid obesity and non-inflammatory benign pathology surgery for non-obese patients). Before the surgical procedures, we evaluated demographic and anthropometric data and biochemical parameters including the studied adipokines. Arterial stiffness was evaluated using a Medexpert ArteriographTM TL2 device. In both groups, adipocyte size and vascular wall thickness as well as local adiponectin activity were analyzed in PVAT from intraoperative biopsies. Results: In our study, adiponectin (p = 0.0003), chemerin (p = 0.0001) and their ratio (p = 0.005) had statistically significant higher mean values in patients with morbid obesity compared to normal-weight patients. In patients with morbid obesity there were significant correlations between chemerin and AS parameters such as aortic pulse wave velocity (p = 0.006) and subendocardial viability index (p = 0.009). In the same group adipocyte size was significantly correlated with another AS parameter, namely, aortic systolic blood pressure (p = 0.030). In normal-weight patients, blood vessel wall thickness positively correlated with AS parameters such as brachial (p = 0.023) and aortic augmentation index (p = 0.023). An important finding was the negative adipoR1 and adipoR2 immunoexpression in PVAT adipocytes of patients with morbid obesity. Additionally, we found significant correlations between blood vessel wall thickness and blood fasting glucose (p < 0.05) in both groups. Conclusions: Chemerin and adipocyte size could be predictive biomarkers for AS in patients with morbid obesity. Given the small number of patients included, our results need further validation.

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Section: Discussioncontrasting

confidence: 63%

Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity

Onofrei

Anisie

Zamfir

et al. 2023

JCM

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“…Further studies are required to answer this question. Nonetheless, several studies have demonstrated the relationship between weight loss (i.e., after lifestyle modifications or surgical interventions) and the reduction of arterial stiffness in both obese animal models and morbid obese patients (Shargorodsky et al, 2006; Rider et al, 2010; Weisbrod et al, 2013; Brunner et al, 2015; Hudson et al, 2017; Manco et al, 2017; Backdahl et al, 2018). In conclusion, since pAMPK, LDH and MMP-9 activities might be easily measured in blood samples, they could be systematically used as potential markers of CV risk and allow for the early identification of patients with an altered intrinsic stiffness and the prevention of further CV damage.…”

Section: Resultsmentioning

confidence: 99%

Beneficial Effect of Bariatric Surgery on Abnormal MMP-9 and AMPK Activities: Potential Markers of Obesity-Related CV Risk

et al. 2019

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Bariatric surgery (BS) results in sustained weight loss and may reverse inflammation, metabolic alterations, extracellular matrix remodeling and arterial stiffness. We hypothesize that increased stiffening in omental arteries from obese patients might be associated with an increase in MMP activity and a decrease in p-AMPK, together with systemic oxidative stress and inflammation. Moreover, BS could contribute to reversing these alterations. This study was conducted with 38 patients of Caucasian origin: 31 adult patients with morbid obesity (9 men and 22 women; mean age 46 years and BMI = 42.7 ± 1.0 kg/m 2 ) and 7 non-obese subjects (7 women; mean age 45 years and BMI = 22.7 ± 0.6 kg/m 2 ). Seventeen obese patients were studied before and 12 months after BS. The stiffness index β, an index of intrinsic arterial stiffness, was determined in omental arteries and was significantly higher in obese patients. Levels of phosphorylated AMPK (p-AMPK Thr-172 ) and SIRT-1 were significantly lower in peripheral blood mononuclear cells (PBMCs) from obese patients than those from non-obese patients ( p < 0.05) and were normalized after BS. Total and active MMP-9 activities, LDH, protein carbonyls and uric acid were higher in obese patients and reduced by BS. Moreover, there was a correlation between plasmatic LDH levels and the stiffness index β. BS has a beneficial effect on abnormal MMP-9, LDH and AMPK activities that might be associated with the development of arterial stiffness in obese patients. Since these parameters are easily measured in blood samples, they could constitute potential biomarkers of cardiovascular risk in morbid obesity.

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“…Intuitively, an allele increasing PWV would also increase CAD risk; however, this only applies for rs565470 (2), whereas the opposite is found for rs3742207 and rs605143 (2,160). It remains elusive whether these variants affect gene expression; however, COL4A1 mRNA levels in lymphoblastoid cells were shown to correlate with increased PWV in 121 female twins over a 4-yr period (20), and white adipose tissue COL4A1 mRNA levels could independently predict improvements in PWV after gastric bypass surgery in 30 patients (8). Artery stiffness or a reduced distensibility of the artery wall results from altered structural properties of proteins such as buildup or cross-linking of fibrillar collagens and breakdown of elastin.…”

Section: Q34 and Artery Stiffeningmentioning

confidence: 99%

A role for collagen type IV in cardiovascular disease?

Steffensen

Rasmussen

2018

American Journal of Physiology-Heart and Circulatory Physiology

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Over the past decade, studies have repeatedly found single-nucleotide polymorphisms located in the collagen ( COL) 4A1 and COL4A2 genes to be associated with cardiovascular disease (CVD), and the 13q34 locus harboring these genes is one of ~160 genome-wide significant risk loci for coronary artery disease. COL4A1 and COL4A2 encode the α- and α-chains of collagen type IV, a major component of basement membranes in various tissues including arteries. Despite the growing body of evidence indicating a role for collagen type IV in CVD, remarkably few studies have aimed to directly investigate such a role. The purpose of this review is to summarize the clinical reports linking 13q34 to coronary artery disease, atherosclerosis, and artery stiffening and to assemble the scattered pieces of evidence from experimental studies based on vascular cells and tissue collectively supporting a role for collagen type IV in atherosclerosis and other macrovascular disease conditions.

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Long-Term Improvement in Aortic Pulse Wave Velocity After Weight Loss Can Be Predicted by White Adipose Tissue Factors

Abstract: Trial Number NCT01727245 (clinicaltrials.gov).

Cited by 13 publications

References 53 publications

Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity

Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity

Beneficial Effect of Bariatric Surgery on Abnormal MMP-9 and AMPK Activities: Potential Markers of Obesity-Related CV Risk

A role for collagen type IV in cardiovascular disease?

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