Long-term longitudinal modifications in mesopic microperimetry in early and intermediate age-related macular degeneration

Abstract

A significant deterioration in RS is reported in early and intermediate AMD eyes, whereas fixation stability changed only in intermediate AMD (AREDS 3) over long-term follow-up. Microperimetry examination can become a new functional biomarker in early and intermediate AMD patients.

Cone photoreceptor macular function and recovery after photostress in early non-exudative age-related macular degeneration

“…In addition, it showed good short-term and long-term repeatability based on high ICC values, although these results are within the context of a small pilot study. Our finding that the baseline cone threshold is compromised in early AMD is consistent with results from studies based on mesopic microperimetry, 38 , 39 which have also shown good test–retest repeatability. 61 …”

Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen

“…Structural biomarkers in intermediate AMD have been assessed by color fundus photography, volumetric spectraldomain optical coherence tomography (SD-OCT) data, qualitative SD-OCT data, and fundus autofluorescence [4]. In terms of structure-function correlation with quantitative SD-OCT data, retinal pigment epithelium + drusen complex (RPEDC) thickness, drusen thickness, and outer retina thickness have been shown to be associated with photopic (standard automated perimetry) sensitivity, rod-mediated dark adaptation as well as mesopic FCP sensitivity [19][20][21][22][23][24][25]. In the setting of reticular drusen, partial outer retinal volume (outer nuclear layer (ONL) and inner segments) was shown to be markedly associated with dark-adapted sensitivity using FCP [8,14].…”

Retest Reliability of Mesopic and Dark-Adapted Microperimetry in Patients With Intermediate Age-Related Macular Degeneration and Age-Matched Controls

“…A good way to detect functional deficits in early stages of AMD is to measure retinal sensitivity determined by funduscontrolled perimetry (FCP), also called ''microperimetry'' or ''gaze contingent perimetry.'' [11][12][13][14][15][16] Studies have shown that functional deficits detected by FCP are correlated to retinal pigment epithelium (RPE) elevation, thinning of the outer segment thickness, and disruption of the second hyperreflective band on spectral-domain optical coherence tomography. [17][18][19] Impaired mesopic and scotopic sensitivity have been spatially correlated with the presence of both large soft drusen and focal abnormalities on fundus autofluorescence intensities.…”