Long-term outcome in children with low grade tectal tumours and obstructive hydrocephalus

Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis

“…We have reported imaging findings, histopathology, molecular analysis and outcomes of children with TG compiled over a period of three decades. The presentation of TG is often typified by symptoms of raised intracranial pressure and delayed diagnosis, with most reports describing a lead time of 3–6 months [ 1 , 4 , 5 , 8 , 15 , 16 , 37 , 39 , 41 , 43 , 45 ]. Misdiagnosis of TG as aqueductal stenosis based on CT, as in three of our patients, was common and was associated with even longer symptom durations before TG diagnosis [ 5 ].…”

The Neurological Predictor Scale: A predictive tool for long‐term core cognitive outcomes in survivors of childhood brain tumors

“…Another study examining the effect of chemotherapy‐only treatment on cognitive outcomes found this treatment to be strongly related to attention deficits in survivors of childhood acute lymphoblastic leukemia . Studies have also suggested a relation between hydrocephalus and attentional deficits . In fact, both chemotherapy and hydrocephalus have been linked to reduced white matter volume, which is reported to be strongly related to attentional deficits .…”

“…43 Studies have also suggested a relation between hydrocephalus and attentional deficits. [44][45][46][47] In fact, both chemotherapy and hydrocephalus have been linked to reduced white matter volume, which is reported to be strongly related to attentional deficits. 48 It is possible that the lack of the expected finding in this study could be a result of reduced power to detect significant differences due to the use of an additional variable (i.e., age) in the hierarchical regression.…”

Long-term supratentorial brain structure and cognitive function following cerebellar tumour resections in childhood

“…Studies aimed at investigating the cognitive role of the cerebellum critically rely on the assumption that resection of cerebellar tissue is the main causal factor explaining structural and cognitive outcomes. If hydrocephalus were to emerge as a more likely primary mechanism, conclusions based on these previous studies would need to be reevaluated (Aarsen et al, 2014;Omar et al, 2014). Therefore, our second aim was to investigate possible mechanisms underlying any group differences by assessing the unique contribution of hydrocephalus severity and cerebellar lesion volumes, respectively.…”