Long-term preservation of vitality of xenogenic thyrocytes in the recipient after their transplantation into the blood stream

Tretyak, S.I.; Prochorov, A.V.; Khryshchanovich, V.J.; Nedzvedz, M. K.; Романович, А. В.

doi:10.2478/v10039-008-0008-x

Cited by 2 publications

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“… 4 Our previous researches on pancreatic islet cells and thyroid cells revealed that grafts into the blood stream may preserve viability and long-term functioning without the use of immunosuppression; therefore, bloodstream is one of the immunologically privileged sites. 5 This case report presents a 3-month clinical follow-up of patients with severe postoperative hypoparathyroidism, in whom parathyroid cell allotransplantation was performed. The patient was symptom free, had no hypocalcemia on lowered doses of oral substitution therapy, and did not need intravenous (IV) calcium after allotransplantation.…”

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confidence: 99%

Allotransplantation of macroencapsulated parathyroid cells as a treatment of severe postsurgical hypoparathyroidism: case report

Khryshchanovich

Ghoussein

2016

Annals of Saudi Medicine

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Persistent hypoparathyroidism, a condition associated with major inconvenience and potential morbidity, is more difficult to treat than other hypofunctional endocrine disorders. Therapeutic alternative in severe postsurgical hypoparathyroidism is allotransplantation of macroencapsulated parathyroid cells. With this technique, it is possible to implant cells or tissues of parathyroid origin to replace them in such patients without immunosuppression. At the present time, durable results have only been reported in parathyroid allotransplantation when immunosuppression to prevent rejection is administered. We report an allotransplant of parathyroid cells in a patient with continuous endovenous requirement of calcium to survive. Macrocapsule containing ~(20 to 30)×106 parathyroid cells was constructed with a polyvinylidine difluoride and implanted into the deep femoral artery. The functional activity of the graft, traced for 3 months, allowed to exclude the parenteral administration of calcium and to compensate symptoms of the disease.

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confidence: 99%