2009
DOI: 10.1161/circep.108.816892
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Long-Term Prognosis of Probands With Brugada-Pattern ST-Elevation in Leads V 1 –V 3

Abstract: for the Brugada Syndrome Investigators in Japan Background-The prognosis of patients with saddleback or noncoved type (non-type 1) ST-elevation in Brugada syndrome is unknown. The purpose of this study was to clarify the long-term prognosis of probands with non-type 1 ECG and those with coved (type 1) Brugada-pattern ECG. Methods and Results-A total of 330 (123 symptomatic, 207 asymptomatic) probands with a coved or saddleback ST-elevation Ն1 mm in leads V 1 -V 3 were divided into 2 ECG groups-type 1 (245 prob… Show more

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Cited by 266 publications
(238 citation statements)
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“…Nevertheless, in the cohort studies examining early repolarization syndrome (ERS), the right precordial leads were not included in the analysis to avoid including BrS or arrhythmogenic right ventricular cardiomyopathy. Kamakura et al extended the definition of non–type 1 BrS and concluded that the long‐term prognosis of probands with non–type 1 BrS was similar to that of probands with type 1 BrS in a hospital‐based multicenter study 23. Moreover, Kamakura et al investigated the significance of non–type 1 anterior ER in patients with idiopathic ventricular fibrillation and inferolateral ER in their hospital‐based study 15.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, in the cohort studies examining early repolarization syndrome (ERS), the right precordial leads were not included in the analysis to avoid including BrS or arrhythmogenic right ventricular cardiomyopathy. Kamakura et al extended the definition of non–type 1 BrS and concluded that the long‐term prognosis of probands with non–type 1 BrS was similar to that of probands with type 1 BrS in a hospital‐based multicenter study 23. Moreover, Kamakura et al investigated the significance of non–type 1 anterior ER in patients with idiopathic ventricular fibrillation and inferolateral ER in their hospital‐based study 15.…”
Section: Discussionmentioning
confidence: 99%
“…[9][10][11] The clinical severity of BrS may vary with the responsible genes and/or mutation sites, although the genotypephenotype relationship remains poorly characterized. The presence of SCN5A mutations is not related to the severity of the disease.9,10,12) However, Meregalli, et al have recently reported that the type of SCN5A mutation in BrS1 in European countries may determine the clinical severity.13) Because the clinical features of BrS vary among different ethnicities, 14,15) it is of great value to investigate the genotype-phenotype relationship of BrS in Asians in whom the ratio of BrS patients is relatively high compared to subjects from different ethnic backgrounds.In the present study, we analyzed the SCN5A gene to elucidate the potential variability of clinical features of BrS1 subjects recruited from Gunma University Hospital. Consequently, we identified 8 SCN5A mutations, including 6 novel mutations, from 30 patients with BrS.…”
mentioning
confidence: 99%
“…We did not avoid performing an SCB test for female patients. A high prevalence of males (>90% of the patients) with BrS was frequently observed in previous Japanese studies,27, 39 and it might be a racial characteristic of BrS.…”
Section: Discussionmentioning
confidence: 60%