Approaches and results of endoscopic transpapillary procedures in the treatment of patients with obstructive jaundice of various origins are analyzed. Modern trends in the development of endobiliary surgery and recommendations devoted to various endoscopic techniques and methods of biliary decompression depending on etiology and severity of obstructive jaundice, management of patients and dates of interventions are described. Leading specialized centers are characterized by quite high effectiveness of endoscopic transpapillary interventions in patients with cholelithiasis complicated by obstructive jaundice (95.2–97.5%), benign biliary strictures (63.7–92.8%) and biliopancreatoduodenal malignancies (70–96.8%). Analysis of modern tactical and technical approaches and international guidelines for transpapillary interventions allowed us to determine the current capabilities of retrograde minimally invasive curative technologies, systematize and optimize the basic algorithms for endoscopic care in patients with obstructive jaundice, and outline the prospects for the introduction and improvement of the effectiveness of new techniques.