Long term thromboresistance of heparinized surfaces

Abstract

It has long been known that interaction of blood with artificial surfaces results in thrombogenic effects. With the increased use of prosthetic cardiovascular appliances, it is becoming more evident that surfaces which are thromboresistant are of utmost importance. A review is presented of the recent research on binding of heparin by ionic, covalent and thermal means, to different polymer surfaces, with the results of in vitro and in vivo tests. Additionally, a survey of theories on the role of heparin surfaces in thromboresistance is given.

Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface

“…The irreversibility, and the analog inertness against plasma, are important in view of the applicability of the surface coatings obtained by the adsorption of P as nonthrombogenic materials. Generally, heparinized coatings possess no permanent stability against plasma or salt solutions (18,19). This may be caused by the much smaller size of the heparin molecule compared to P, resulting in a smaller number of adsorption sites per molecule.…”

Antithrombogenic Heparin-Bound Polyurethanes

“…[11, are relatively thromboresistant. The properties and preparation of heparinized materials have been reviewed by Leininger [2], Ehrlich [3], Wilson [4], and Ebert and Kim [5]. Various methods of heparinization have been developed.…”