Long-term treatment of congestive heart failure by Captopril: hemodynamic, biological and clinical effects

Kayanakis, J G; Jm, Fauvel; Giraud, P; Bounhoure, Jean-Paul

doi:10.1093/oxfordjournals.eurheartj.a061166

Cited by 12 publications

(2 citation statements)

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“…Captopril may be administered with diuretics to manage renal clearance. There have been number of studies using captopril with diuretics [4][5][6][7][8][9][10][11][12][13]. Hydrochlorothiazide (HCT) and furosemide (FRS) have widely been used in the treatment of congestive heart failure and hypertension [14,15] (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

RP-HPLC Method for Simultaneous Determination of Captopril and Diuretics: Application in Pharmaceutical Dosage Forms and Human Serum

Sultana¹,

Arayne²,

Sattar³

2011

J Chromatograph Separat Techniq

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An isocratic reversed phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of captopril and diuretics (furosemide and hydrochlorothiazide) in API, dosage formulations and human serum. Chromatographic separation was achieved on Purospher Start C18 (250 mm x 4.6 mm, 5 μm) and Hypersil ODS C18 (150×4.6mm, 5micron) columns using mobile phase, methanol: water (70:30 v/v) adjusted to pH 3.0 via phosphoric acid 85% having flow rate of 1.0 mL min-1 at ambient temperature with detector set at 225 nm. Calibration curves were linear over range of 5-25 μg mL-1 with a correlation coefficient ± 0.999. LOD and LOQ were in the ranges of 0.4-2.3 μg mL-1. Intra and inter-run precision and accuracy results were 98.0 to 102%.

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Section: Introductionmentioning

confidence: 99%

RP-HPLC Method for Simultaneous Determination of Captopril and Diuretics: Application in Pharmaceutical Dosage Forms and Human Serum

Sultana¹,

Arayne²,

Sattar³

2011

J Chromatograph Separat Techniq

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“…Systemic vasodilation results in improved left ventricular function (Davis et al, 1979;Kayanakis et al, 1981;Awan et al, 1982), whereas reversal of renal vasoconstriction and reduced aldosterone synthesis (Atlas et al, 1979;Creager et al, 1981, Dzau et al, 1981 cause a natriuresis and hence a decrease in salt and water retention.…”

Section: Introductionmentioning

confidence: 99%

Long‐term captopril therapy in severe refractory congestive heart failure.

Steingo¹,

Wa²,

Flax³

et al. 1982

Brit J Clinical Pharma

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1 The favourable haemodynamic effects of captopril in patients with congestive heart failure have been reported. 2 We have treated 25 patients with severe chronic congestive heart failure with captopril in doses of 75‐450 mg daily. Before entering the study all patients remained in New York Heart Association functional class IV despite high‐ dose diuretic and vasodilator therapy. 3 Mean cardiothoracic ratio was 60%, and all patients had a shortening fraction of 18% or less on echocardiography (normal 25 to 40%). 4 Five patients died within one month of captopril and five between four and seven months, three of whom had improved to class IIM and one to IIS before death. 5 Of the 15 survivors one was referred for a heart transplant when he had improved to class IIM. The remaining 14 patients were followed for 8‐16 months. Ten improved to New York Heart Association class I or IIS and four to class IIM or III. Diuretic requirements were decreased considerably in all 14. Side effects were common but captopril did not have to be withdrawn. Captopril is a highly effective drug in the treatment of patients with congestive heart failure refractory to currently accepted therapy.

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Vasodilators in the Treatment of Congestive Heart Failure

Canella¹,

Sendón²

1988

Therapeutics in Cardiology

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Long-term treatment of congestive heart failure by Captopril: hemodynamic, biological and clinical effects

Cited by 12 publications

References 0 publications

RP-HPLC Method for Simultaneous Determination of Captopril and Diuretics: Application in Pharmaceutical Dosage Forms and Human Serum

RP-HPLC Method for Simultaneous Determination of Captopril and Diuretics: Application in Pharmaceutical Dosage Forms and Human Serum

Long‐term captopril therapy in severe refractory congestive heart failure.

Vasodilators in the Treatment of Congestive Heart Failure

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