Body mass is a very significant factor for influencing longevity. Generally, large animal species tend to live longer than small species. In domestic dogs, the relationship between body size and lifespan shows opposite trend and increasing bodyweight is negatively correlated with longevity. Crossbred dogs have increased longevity, compared with purebreds. In the Cane Corso Italiano breed, a relationship between longevity and hair colour was found for the first time in mammals.Understanding longevity and aging across species and individuals is critical for reaching higher ages at death in animals, as well as in humans. By understanding genetics, the age limits of animals and humans can be significantly prolonged. Detection and analysis of genes associated with longevity present a very promising method for prolonging life.