Longitudinal neural and vascular structural dynamics produced by chronic microelectrode implantation

Welle, Cristin G.; Gao, Yurong; Ye, Meijun; Lozzi, Andrea; Boretsky, Adam; Abliz, Erkinay; Hammer, Daniel X.

doi:10.1016/j.biomaterials.2020.119831

Cited by 20 publications

(29 citation statements)

References 47 publications

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“…This process causes acute and chronic tissue damage 5 and implants suffer material degradation. These factors limit longevity and performance [6][7][8] . In addition, invasive electrodes are difficult to scale and limited in sampling density and brain coverage.…”

Section: Mainmentioning

confidence: 99%

Single-trial decoding of movement intentions using functional ultrasound neuroimaging

Norman

Maresca

Christopoulos

et al. 2021

Neuron

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Brain-machine interfaces (BMI) are powerful devices for restoring function to people living with paralysis. Leveraging significant advances in neurorecording technology, computational power, and understanding of the underlying neural signals, BMI have enabled severely paralyzed patients to control external devices, such as computers and robotic limbs. However, high-performance BMI currently require highly invasive recording techniques, and are thus only available to niche populations. Here, we show that a minimally invasive neuroimaging approach based on functional ultrasound (fUS) imaging can be used to detect and decode movement intention signals usable for BMI. We trained non-human primates to perform memory-guided movements while using epidural fUS imaging to record changes in cerebral blood volume from the posterior parietal cortex -a brain area important for spatial perception, multisensory integration, and movement planning. Using hemodynamic signals acquired during movement planning, we classified left-cued vs. right-cued movements, establishing the feasibility of ultrasonic BMI. These results demonstrate the ability of fUS-based neural interfaces to take advantage of the excellent spatiotemporal resolution, sensitivity, and field of view of ultrasound without breaching the dura or physically penetrating brain tissue.

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Section: Mainmentioning

confidence: 99%

Single-trial decoding of movement intentions using functional ultrasound neuroimaging

Norman

Maresca

Christopoulos

et al. 2021

Neuron

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“…This correlates with the observation that blood along the probe tract induces stronger acidosis, an expected consequence of more severe local inflammation (Johnson et al, 2007). In a recent study, Welle et al (2020) combined in vivo two-photon imaging of neurons with optical coherence tomography to allow label-free imaging of blood vessels (Welle et al 2020). They studied the interplay between vascular and structural dynamics around single-and multishank silicon probes over three months.…”

Section: Acute and Chronic Bleedingmentioning

confidence: 64%

“…When a probe is inserted into the brain, this action invariably inflicts trauma on the surrounding tissue. Multiple factors contribute to this initial trauma, including the purely mechanical damage to the brain structure and cells (Eles and Kozai 2020), any bleeding that occurs as a result of this (Kozai et al 2012), and the impact of this bleeding in the surrounding neural tissue (Welle et al 2020). As the probe advances through the tissue, it will destroy or displace cells and axons in its path, like a stab wound (Polikov et al 2005;Michelson et al 2018;Eles and Kozai 2020;Welle et al 2020).…”

Section: Minimizing Probe Insertion Traumamentioning

confidence: 99%

“…Multiple factors contribute to this initial trauma, including the purely mechanical damage to the brain structure and cells (Eles and Kozai 2020), any bleeding that occurs as a result of this (Kozai et al 2012), and the impact of this bleeding in the surrounding neural tissue (Welle et al 2020). As the probe advances through the tissue, it will destroy or displace cells and axons in its path, like a stab wound (Polikov et al 2005;Michelson et al 2018;Eles and Kozai 2020;Welle et al 2020). The extent of this initial trauma both depends on the design of the device itself (cross-section and tip shape), the surgical technique, and the tools used to assist the insertion as summarized in the previous section (Sharp et al 2009;Weltman et al 2016;Lecomte et al 2018;Wellman et al 2018).…”

Section: Minimizing Probe Insertion Traumamentioning

confidence: 99%

“…Thus, the smaller the probe, the less impact it will have on the natural perfusion of the tissue, and the more likely the surrounding neurons will remain healthy (Karumbaiah et al 2013). Researchers have determined that even in the presence of blood vessels, reduced perfusion surrounding neural probes impacts neuronal health and activity (Kozai et al 2012;Michelson et al 2018;Welle et al 2020). In summary, making probes smaller may be more critical to their success than making them flexible Kozai 2018).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Engineering strategies towards overcoming bleeding and glial scar formation around neural probes

2022

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Neural probes are sophisticated electrophysiological tools used for intra-cortical recording and stimulation. These microelectrode arrays, designed to penetrate and interface the brain from within, contribute at the forefront of basic and clinical neuroscience. However, one of the challenges and currently most significant limitations is their ‘seamless’ long-term integration into the surrounding brain tissue. Following implantation, which is typically accompanied by bleeding, the tissue responds with a scarring process, resulting in a gliotic region closest to the probe. This glial scarring is often associated with neuroinflammation, neurodegeneration, and a leaky blood–brain interface (BBI). The engineering progress on minimizing this reaction in the form of improved materials, microfabrication, and surgical techniques is summarized in this review. As research over the past decade has progressed towards a more detailed understanding of the nature of this biological response, it is time to pose the question: Are penetrating probes completely free from glial scarring at all possible?

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Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin‐Film Intracortical Implants

et al. 2023

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Flexible implantable neurointerfaces show great promise in addressing one of the major challenges of implantable neurotechnology, namely the loss of signal connected to unfavorable probe tissue interaction. The authors here show how multilayer polyimide probes allow high‐density intracortical recordings to be combined with a reliable long‐term stable tissue interface, thereby progressing toward chronic stability of implantable neurotechnology. The probes could record 10–60 single units over 5 months with a consistent peak‐to‐peak voltage at dimensions that ensure robust handling and insulation longevity. Probes that remain in intimate contact with the signaling tissue over months to years are a game changer for neuroscience and, importantly, open up for broader clinical translation of systems relying on neurotechnology to interface the human brain.

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Longitudinal neural and vascular structural dynamics produced by chronic microelectrode implantation

Cited by 20 publications

References 47 publications

Single-trial decoding of movement intentions using functional ultrasound neuroimaging

Single-trial decoding of movement intentions using functional ultrasound neuroimaging

Engineering strategies towards overcoming bleeding and glial scar formation around neural probes

Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin‐Film Intracortical Implants

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