Longitudinally extensive transverse myelitis caused by Chikungunya virus

Jain, Rajendra Singh; Khan, Ibraheem; Saini, Pankaj

doi:10.1016/j.injms.2016.12.003

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…Due to the rarity of this condition, no significant data regarding the management of CHIKV-associated LETM is available. The previous case of CHIKV-associated LETM was managed with high dose intravenous steroids with good functional outcome 2. In our case, a similar positive outcome was seen with the steroids.…”

Section: Discussionsupporting

confidence: 82%

“…Encephalopathy is the most common CHIKV-associated neurological complication; however, cases of acute disseminated encephalomyelitis, Guillain-Barre syndrome, myeloradiculitis, myelitis and neuro-ocular diseases (uveitis, retinitis, optic neuritis) have also been reported 1. CHIKV-associated LETM is very rare and only two cases have been reported in literature 2 3. We are reporting the first case of CHIKV-associated LETM from Pakistan and we have previously reported a case series of CHIKV-associated Guillain-Barre syndrome presenting in our institution 6…”

Section: Discussionmentioning

confidence: 99%

“…Chikungunya viral (CHIKV) fever is generally considered a self-limiting febrile illness associated with severe debilitating arthralgia. Although CHIKV-associated neurological complications have been reported in literature, they are uncommon and,1 longitudinally extensive transverse myelitis (LTEM) is very rare and has only been reported in two previous cases worldwide 2 3…”

Section: Introductionmentioning

confidence: 99%

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Longitudinally extensive transverse myelitis with seropositive chikungunya

Hameed¹,

Memon

Imtiaz

et al. 2019

BMJ Case Rep

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Chikungunya viral (CHIKV) fever is often a self-limiting febrile illness associated with severe debilitating arthralgia. Neurological complications associated with CHIKV, although rare, have been reported in literature; however, longitudinally extensive transverse myelitis (LTEM) is rarely associated with it. We present a case of a middle-aged man with a 1-week history of low-grade fever and arthralgia followed by urinary retention and quadriplegia. A sensory level was noted at T2. On subsequent investigations, he was diagnosed with LETM. Although LETM is commonly seen in patients with neuromyelitis optica, the other possible etiologies are inflammatory and parainfectious. To date, only two cases of LETM are reported worldwide in association with CHIKV fever and this is the first case from Pakistan. With frequent chikungunya outbreaks, neurological complications are increasingly seen in clinical practice. The knowledge of these associations will result in their early diagnosis and treatment.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Longitudinally extensive transverse myelitis with seropositive chikungunya

Hameed¹,

Memon

Imtiaz

et al. 2019

BMJ Case Rep

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“…Atypical presentations with myocarditis, hepatitis and meningoencephalitis may also occur 3. Cases of transverse myelitis and Guillain-Barré syndrome (GBS) secondary to CHIK fever have been reported 4–6. Although these cases are rare, with frequent outbreaks of CHIK fever, they are increasingly being seen in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Rare variant of Guillain-Barré syndrome after chikungunya viral fever

Hameed¹,

Khan

2019

BMJ Case Rep

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Chikungunya (CHIK) viral fever is a self-limiting illness that presents with severe debilitating arthralgia, myalgia, fever and rash. Neurological complications are rare. We present a case of a 36-year-old woman who presented with acute onset progressive difficulty swallowing and left arm weakness. She was diagnosed with CHIK viral fever 4 weeks prior to admission. After investigations, she was diagnosed with a pharyngeal–cervical–brachial variant of Guillain-Barré syndrome. In hospital, she required ventilator support. Her condition improved after five sessions of intravenous immunoglobulin with almost complete resolution within 6 months of symptom onset. With frequent CHIK outbreaks, the neurological complications are increasingly seen in the emergency department. The knowledge of these associations will result in early diagnosis and treatment.

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The medicinal chemistry of Chikungunya virus

Silva-Júnior

Leoncini

Rodrigues

et al. 2017

Bioorganic & Medicinal Chemistry

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Arthropod-borne viruses (arboviruses) are an important threat to human and animal health globally. Among these, zoonotic diseases account for billions of cases of human illness and millions of deaths every year, representing an increasing public health problem. Chikungunya virus belongs to the genus Alphavirus of the family Togariridae, and is transmitted mainly by the bite of female mosquitoes of the Aedes aegypti and/or A. albopictus species. The focus of this review will be on the medicinal chemistry of Chikungunya virus, including synthetic and natural products, as well as rationally designed compounds.

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Longitudinally extensive transverse myelitis caused by Chikungunya virus

Cited by 3 publications

References 6 publications

Longitudinally extensive transverse myelitis with seropositive chikungunya

Longitudinally extensive transverse myelitis with seropositive chikungunya

Rare variant of Guillain-Barré syndrome after chikungunya viral fever

The medicinal chemistry of Chikungunya virus

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