Looking into the possibilities of cure of the type 2 diabetes mellitus by nanoparticle-based RNAi and CRISPR-Cas9 system: A review

Roy, Payal; Saha, Suman; Chakraborty, Jayanta

doi:10.1016/j.jddst.2021.102830

Cited by 7 publications

(1 citation statement)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 A number of genes are involved in diabetes development and current therapeutic strategies are only able to delay disease development, while none offer a permanent cure. 15 Existing therapeutic approaches rely on the identification of preventative risk factors or discovery drug targets to manage the diabetic condition/complication after its onset. Hence, novel therapeutic strategies are required to manage complications of diabetes effectively.…”

Section: Type 2 Diabetesmentioning

confidence: 99%

Application of CRISPR‐Cas9 technology in diabetes research

Lotfi,

Butler,

Sukhorukov

et al. 2023

Diabet Med

View full text Add to dashboard Cite

Diabetes is a chronic disorder with rapidly increasing prevalence that is a major global issue of our current era. There are two major types of diabetes. Polygenic forms of diabetes include type 1 diabetes (T1D) and type 2 diabetes (T2D) and its monogenic forms are maturity‐onset diabetes of the young (MODY) and neonatal diabetes mellitus (NDM). There are no permanent therapeutic approaches for diabetes and current therapies rely on regular administration of various drugs or insulin injection. Recently, gene editing strategies have offered new promise for treating genetic disorders. Targeted genome editing is a fast‐growing technology, recruiting programmable nucleases to specifically modify target genomic sequences. These targeted nucleases generate double‐strand breaks at target regions in the genome, which induce cellular repair pathways including non‐homologous end joining (NHEJ) and homology‐directed repair (HDR). Clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9) is a novel gene‐editing system, permitting precise genome modification. CRISPR/Cas9 has great potential for various applications in diabetic research such as gene screening, generation of diabetic animal models and treatment. In this article, gene‐editing strategies are summarized with a focus on the CRISPR/Cas9 approach in diabetes research.

show abstract

Section: Type 2 Diabetesmentioning

confidence: 99%

Application of CRISPR‐Cas9 technology in diabetes research

Lotfi,

Butler,

Sukhorukov

et al. 2023

Diabet Med

View full text Add to dashboard Cite

show abstract

A critical review on therapeutic approaches of CRISPR-Cas9 in diabetes mellitus

Dey

Lyngdoh

Dhasmana

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Exploring cutting-edge approaches in diabetes care: from nanotechnology to personalized therapeutics

Asaad,

Doghish,

Rashad

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a persistent condition characterized by high levels of glucose in the blood due to irregularities in the secretion of insulin, its action, or both. The disease was believed to be incurable until insulin was extracted, refined, and produced for sale. In DM, insulin delivery devices and insulin analogs have improved glycemic management even further. Sulfonylureas, biguanides, alpha-glucosidase inhibitors, and thiazolidinediones are examples of newer-generation medications having high efficacy in decreasing hyperglycemia as a result of scientific and technological advancements. Incretin mimetics, dual glucose-dependent insulinotropic polypeptide, GLP-1 agonists, PPARs, dipeptidyl peptidase-4 inhibitors, anti-CD3 mAbs, glucokinase activators, and glimins as targets have all performed well in recent clinical studies. Considerable focus was placed on free FA receptor 1 agonist, protein tyrosine phosphatase-1B inhibitors, and Sparc-related modular calcium-binding protein 1 which are still being studied. Theranostics, stem cell therapy, gene therapy, siRNA, and nanotechnology are some of the new therapeutic techniques. Traditional Chinese medicinal plants will also be discussed. This study seeks to present a comprehensive analysis of the latest research advancements, the emerging trends in medication therapy, and the utilization of delivery systems in treating DM. The objective is to provide valuable insights into the application of different pharmaceuticals in the field of diabetes mellitus treatment. Also, the therapeutic approach for diabetic patients infected with COVID-19 will be highlighted. Recent clinical and experimental studies evidence the Egyptian experience. Finally, as per the knowledge of the state of the art, our conclusion and future perspective will be declared.

show abstract

Looking into the possibilities of cure of the type 2 diabetes mellitus by nanoparticle-based RNAi and CRISPR-Cas9 system: A review

Cited by 7 publications

References 121 publications

Application of CRISPR‐Cas9 technology in diabetes research

Application of CRISPR‐Cas9 technology in diabetes research

A critical review on therapeutic approaches of CRISPR-Cas9 in diabetes mellitus

Exploring cutting-edge approaches in diabetes care: from nanotechnology to personalized therapeutics

Contact Info

Product

Resources

About