Loss of expression of blood group antigen H is associated with cellular invasion and spread of oral squamous cell carcinomas

Bryne, Magne; Thrane, P. S.; Dabelsteen, Erik

doi:10.1002/1097-0142(19901115)66:10<2118::aid-cncr2820661013>3.0.co;2-2

Cited by 18 publications

(14 citation statements)

References 20 publications

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“…Their results are not directly comparable with our results, since we focused the attention on whether H antigen could be used as a tumor marker irrespective of ABO status. Contrary to the present study, Bryne et al 22 did not find a significant prognostic value for H‐antigen expression alone in oral SCCs. This discrepancy may be due to different antibodies used and to different locations of the tumors.…”

Section: Discussioncontrasting

confidence: 99%

“…This is in agreement with the results reported from several other types of tumors 3,18,19 . Concerning oral squamous cell carcinomas, we are aware of three studies which have related H‐antigen expression to prognosis, 20‐22 but none of these or other studies we are aware of have correlated Le y expression to prognosis. Carey et al 20 and Wolf et al 21 observed that patients whose tumor had lost their ABH antigens had poorer prognosis than those whose tumor had not.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Prognostic Value of Le^y and H Antigens in Oral Tongue Carcinomas

Xie¹,

Boysen²,

Clausen³

et al. 1999

The Laryngoscope

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 91%

Prognostic Value of Le^y and H Antigens in Oral Tongue Carcinomas

Xie¹,

Boysen²,

Clausen³

et al. 1999

The Laryngoscope

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“…Loss of A and B Figure 1. The ABH determinants are composed of L-fucose, Dgalactose, and D-N-acetylgalactosamine, with a minimal determinant structure and the synthetic pathway as described in the text (Yamamoto et al, 1990 (Dabelsteen et al, 1983;Bryne et al, 1991;Le Pendu et al, 2001). Immunohistochemical studies of oral squamous cell carcinomas have shown loss of expression of A or B antigens in more than 80% of cases, all of which showed concomitant loss of A/B transferase (Figs.…”

Section: Cancer and Precancermentioning

confidence: 99%

ABO Blood-group Antigens in Oral Cancer

Dabelsteen

Gao

2005

J Dent Res

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Tumor progression is often associated with altered glycosylation of the cell-surface proteins and lipids. The peripheral part of these cell-surface glycoconjugates often carries carbohydrate structures related to the ABO and Lewis blood-group antigens. The expression of histo-blood-group antigens in normal human tissues is dependent on the type of differentiation of the epithelium. In most human carcinomas, including oral carcinoma, a significant event is decreased expression of histo-blood-group antigens A and B. The mechanisms of aberrant expression of blood-group antigens are not clear in all cases. A relative down-regulation of the glycosyltransferase that is involved in the biosynthesis of A and B antigens is seen in oral carcinomas in association with tumor development. The events leading to loss of A transferase activity are related, in some instances, to loss of heterozygosity (LOH) involving chromosome 9q34, which is the locus for the ABO gene, and in other cases, to a hypermethylation of the ABO gene promoter. The fact that hypermethylation targets the ABO locus, but not surrounding genes, suggests that the hypermethylation is a specific tumor-related event. However, since not all situations with lack of expression of A/B antigens can be explained by LOH or hypermethylation, other regulatory factors outside the ABO promoter may be functional in transcriptional regulation of the ABO gene. Altered blood group antigens in malignant oral tissues may indicate increased cell migration. This hypothesis is supported by studies showing that normal migrating oral epithelial cells like malignant cells show lack of expression of A/B antigens, and by studies that target ABH antigens to key receptors controlling adhesion and motility, such as integrins, cadherins, and CD-44.

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“…An ABC-peroxidase immunohistochemical staining method was used as previously described (Bryne et at., 1991b). Sialic acid was removed from the tissues by neuraminidase prior to incubation of the antibodies 1B2 and HH8 as earlier reported (Bryne et aI., 1991a).…”

Section: Immunohistochemical Stainingmentioning

confidence: 99%

Distribution of blood-group-related carbohydrate antigens on oral endothelial cells

et al. 1993

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Recent studies indicate that carbohydrate structures are involved in various endothelial functions such as inflammatory processes, adhesion of metastatic cells to endothelium and endothelial differentiation. In this paper we report the endothelial expression of various blood-group-related carbohydrate structures in normal oral mucosa using 15 different monoclonal antibodies reacting with type 1, 2 or 3 carbohydrate chains. Twenty biopsies, including normal oral mucosa, from secretor individuals comprised nine blood group O, nine A, one B and one AB. Endothelial staining was compared with epithelial staining in the same biopsies. Five blood-group-related carbohydrate antigens were detected on endothelial cells. The H type 2 antigen, which is the precursor of A, B and AB antigens, has previously been believed to be a universal marker for endothelial cells. All blood group O individuals (n = 9) showed strong H antigen staining in the endothelium of most vessels. However, of blood group A, B and AB individuals (n = 11), four showed heterogenous H antigen staining. In addition, we found that six out of ten blood group A or AB individuals, who expressed A or A and B antigens on spinous squamous cells and glandular epithelium, showed either heterogenous or no staining for these structures on their endothelial cells. It is concluded that there are differences between the biosynthesis of blood-group-related carbohydrate antigens in oral endothelium and epithelium.

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Loss of expression of blood group antigen H is associated with cellular invasion and spread of oral squamous cell carcinomas

Cited by 18 publications

References 20 publications

Prognostic Value of Le^y and H Antigens in Oral Tongue Carcinomas

Prognostic Value of Le^y and H Antigens in Oral Tongue Carcinomas

ABO Blood-group Antigens in Oral Cancer

Distribution of blood-group-related carbohydrate antigens on oral endothelial cells

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Loss of expression of blood group antigen H is associated with cellular invasion and spread of oral squamous cell carcinomas

Cited by 18 publications

References 20 publications

Prognostic Value of Ley and H Antigens in Oral Tongue Carcinomas

Prognostic Value of Ley and H Antigens in Oral Tongue Carcinomas

ABO Blood-group Antigens in Oral Cancer

Distribution of blood-group-related carbohydrate antigens on oral endothelial cells

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Product

Resources

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Prognostic Value of Le^y and H Antigens in Oral Tongue Carcinomas

Prognostic Value of Le^y and H Antigens in Oral Tongue Carcinomas