Loss of muscle mass in women with premature ovarian insufficiency as compared with healthy controls

Abstract

Women with premature ovarian insufficiency (POI) exhibit significant loss of muscle mass as compared to healthy controls. Early diagnosis and long-term health management in patients with POI are important.

Longitudinal Association between Uric Acid and Incident Sarcopenia

“…Estrogen has been reported to promote the excretion of UA, which may result in elevated UA levels in menopausal females [ 31 ]. In addition, the decrease of estrogen could increase pro-inflammatory cytokines, such as tumor necrosis factor alpha or interleukine-6, which contributes to muscle catabolism [ 32 , 33 ]. Alterations in estrogen levels before and after menopause may partially attenuate the significant association between UA and incident sarcopenia in females.…”

Sarcopenia and menopause

“…In this issue of Menopause , Li et al screened for low muscle mass in an Asian population with premature ovarian insufficiency (POI) at younger than 40 yr of age compared with an age-matched reproductive-capable population. In this relatively modest-sized POI population, they found a significant loss of appendicular muscle mass as determined by DEXA compared with healthy controls in their cross-sectional analysis 6 …”

“…In this relatively modest-sized POI population, they found a significant loss of appendicular muscle mass as determined by DEXA compared with healthy controls in their cross-sectional analysis. 6 In the menopausal population, the prevalence of sarcopenia varies depending on the above definitions. In women over 60 yr, the prevalence of sarcopenia is 9% (95% confidence interval, 7-11%), whereas, in men, it is 11% (95% confidence interval, 8-13%) with increases of 0.5% to 1% per year.…”

“…The association of a low estrogen environment such as surgical menopause or premature ovarian insufficiency as shown by Li et al suggests a major role for estrogen in maintaining muscle mass. 6 Estrogen's direct effect can be mediated by estrogen receptors present in skeletal muscle 9 or indirectly by altered secretion of insulin growth factor (IGF-1) and growth hormone (GH). 10 Estrogen receptor concentrations are higher in children and reproductive-aged women compared with postmenopausal women.…”