Loss of S100A14 expression at the tumor‐invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma

Pandey, Sushma; Osman, Tarig Al-Hadi; Sharma, Sunita; Vallenari, Evan Michael; Shahdadfar, Aboulghassem; Pun, Chin Bahadur; Gautam, Dej Kumar; Uhlin‐Hansen, Lars; Rikardsen, Oddveig G; Johannessen, Anne Christine; Costea, Daniela Elena; Sapkota, Dipak

doi:10.1002/hed.26140

Cited by 14 publications

(7 citation statements)

References 40 publications

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“…In contrast, S100A14 suppresses nasopharyngeal carcinoma (NPC) metastasis by inhibiting the NF-κB signaling pathway and reversing EMT. Lower S100A14 expression is significantly correlated with shorter patient OS and distant metastasis-free survival in NPC patients (42), same in oral squamous cell carcinoma (OSCC) (43)(44)(45). Nevertheless, the analysis in the present study also supported that the expression of S100A14 is decreased in HNSCC and that low expression of this protein is associated with pathological nodal extracapsular spread and lymphovascular invasion.…”

Section: Discussionsupporting

confidence: 64%

An integrated bioinformatics analysis of the S100 in head and neck squamous cell carcinoma

Guo¹,

Yue²,

You³

et al. 2023

Transl Cancer Res

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Background: This study aims to evaluate the expression profile and clinical value of the S100 family in head and neck squamous cell carcinoma (HNSCC). Methods:The expression patterns, clinicopathological features, prognostic significance and underlying correlations of S100 family genes in HNSCC were determined by bioinformatics analysis with the application of several databases, including the The Cancer Genome Atlas (TCGA) and Oncomine for differential expression gene (DEG) analysis, and a series of analysis tools, including Database for Annotation, Visualization and Integrated Discovery (DAVID), cBioPortal, Kaplan-Meier Plotter, Tumor Immune Estimation Resource (TIMER) and R software packages. Results:The results from the study demonstrated that S100A4, S100A10, and S100A13 may act as prognostic markers through overall survival (OS), disease-free survival (DFS) and tumor infiltrating immune cell enrichment and a prognostic S100 family gene model comprising S100A1-A4, S100A8, S100A10, S100A12, and S100A13 was identified. The messenger RNA (mRNA) expression of S100A1, S100A9, S100A14, and S100A7A was significantly different in HNSCC patients, together with a high mutation rate of the S100 family was found. Evaluation of clinicopathological value demonstrated the heterogeneity of S100 family functions. S100A1, S100A7, S100A8, S100A9, S100A13, S100A14, and S100A16 were observed to significantly correlate with multiple biological processes (BPs) of HNSCC, including initiation, lymph node metastasis, and lymphovascular invasion. In addition, the S100 family were significantly associated with epithelial-mesenchymal transition (EMT)-related genes.Conclusions: This present study demonstrated that S100 family members are implicated in the initiation, progression, metastasis and survival of HNSCC.

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Section: Discussionsupporting

confidence: 64%

An integrated bioinformatics analysis of the S100 in head and neck squamous cell carcinoma

Guo¹,

Yue²,

You³

et al. 2023

Transl Cancer Res

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show abstract

“…Notably, the data from a Norwegian team showed that the loss of S100A14 expression is associated with an invasive phenotype in oral cancer [ 16 ]. Specifically, loss of S100A14 expression at the tumor-invading front was found to be associated with poor differentiation and worse prognosis [ 17 ]. In addition, a recent study proved that S100A14 suppresses the metastasis of nasopharyngeal carcinoma [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

CAV2 promotes the invasion and metastasis of head and neck squamous cell carcinomas by regulating S100 proteins

et al. 2022

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More than half of HNSCC patients are diagnosed with advanced disease. Locally advanced HNSCC is characterized by tumors with marked local invasion and evidence of metastasis to regional lymph nodes. CAV2 is a major coat protein of caveolins, important components of the plasma membrane. In this study, CAV2 was found to profoundly promote invasion and stimulate metastasis in vivo and in vitro. CAV2 was demonstrated to be a key regulator of S100 protein expression that upregulates the proteins levels of S100s, which promotes the invasion and migration and downregulates the expression of tumor suppressors. Mechanistically, CAV2 directly interacts with S100s in HNSCC cells, and CAV2 reduces S100A14 protein expression by promoting its ubiquitylation and subsequent degradation via the proteasome. Moreover, we discovered that CAV2 promotes the interaction between S100A14 and the E3 ubiquitin ligase TRIM29 and increases TRIM29 expression. Taken together, our findings indicate that CAV2 promotes HNSCC invasion and metastasis by regulating the expression of S100 proteins, presenting a novel potential target for anticancer therapy in HNSCC.

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“…Changes in the expression of S100 protein members differ in OSCC. The results of previous studies have demonstrated that the expression levels of S100A1, S100A3, S100A6, S100A11, S100A13, S100A14, S100A16 and S100Z are decreased in patients with OSCC, while the expression levels of S100A2, S100A4, S100A7, S100A8, S100A10, S100A12 and S100P are increased (15,(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). In a previous study, the transcriptome analysis of 93 specimens from OSCC tissues and 87 specimens from adjacent tissues demonstrated that the S100A1 and S100A4 expression levels were significantly decreased in OSCC, while those of S100A2, S100A3, S100A7 and S100A11 were increased, compared with those in adjacent tissues (47).…”

Section: S100 Proteins In Osccmentioning

confidence: 99%

S100 proteins in head and neck squamous cell carcinoma (Review)

Han

et al. 2023

Oncol Lett

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The most common tumor affecting the head and neck is head and neck squamous cell carcinoma (HNSCC). The characteristics of HNSCC include a rapid onset, a lack of early diagnosis, drug resistance, relapse and systemic adverse effects, leading to inadequate prevention, diagnosis and treatment. Notably, previous research suggests that there is an association between S100 proteins and HNSCC. S100A8, S100A9 and S100A14 interfere with tumor cell proliferation by blocking the cell cycle. The present review discusses this association. S100A4 enhances cancer stem cell properties, and interacts with actin and tropomyosin to promote tumor cell migration. S100A1, S100A8, S100A9, S100A10, S100A14 and S100P are involved in the initiation and progression of HNSCC via Hippo, nuclear factor κB, phosphatidylinositol kinase/protein kinase B/mammalian target of rapamycin and other signaling pathways. In addition, certain long non-coding RNAs and microRNAs are involved in regulating the expression of S100 proteins in HNSCC. Reducing the expression of certain members of the S100 protein family may enhance the chemosensitivity of HNSCC. Collectively, it is suggested that S100 proteins may function as markers and targets for the prevention, diagnosis and treatment of HNSCC.

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Loss of S100A14 expression at the tumor‐invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma

Cited by 14 publications

References 40 publications

An integrated bioinformatics analysis of the S100 in head and neck squamous cell carcinoma

An integrated bioinformatics analysis of the S100 in head and neck squamous cell carcinoma

CAV2 promotes the invasion and metastasis of head and neck squamous cell carcinomas by regulating S100 proteins

S100 proteins in head and neck squamous cell carcinoma (Review)

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