Low and high locomotor responsiveness to cocaine predicts intravenous cocaine conditioned place preference in male Sprague–Dawley rats

Allen, Richard M.; Everett, Carson V.; Nelson, Anna M.; Gulley, Joshua M.; Zahniser, Nancy R.

doi:10.1016/j.pbb.2006.12.005

Cited by 56 publications

(83 citation statements)

References 40 publications

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“…Previous studies have also failed to demonstrate a significant relationship between cocaine response and CPP (Kosten and Miserendino, 1998;Brabant et al, 2005). A recent study has demonstrated that division into low and high cocaine responders can predict the development of CPP to cocaine, but only when administration is by the intravenous and not intraperitoneal route (Allen et al 2007). Thus, we may have observed a different relationship between cocaine response and CPP using an alternative route of cocaine administration.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous expression of cocaine-induced behavioral sensitization and conditioned place preference in individual rats

Seymour

Wagner

2008

Brain Research

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Conditioned place preference and locomotor sensitization are rodent behavioral models commonly used to investigate the actions of drugs of abuse. However, few studies have examined both paradigms in the same group of animals. We were interested in developing a combined protocol which successfully induced both conditioned place preference and sensitization simultaneously in cocainetreated Sprague Dawley rats in order to test the hypothesis that the magnitude of these two phenomena would be positively correlated. We used an open-field with a removable place preference insert to assess these measures independently. Cocaine-conditioned animals demonstrated a significant shift in preference for the drug-paired compartment and a sensitized locomotor response which was not observed in saline-conditioned animals challenged with cocaine. There was no significant relationship between locomotor sensitization and conditioned place preference in individual animals. We further examined these results with respect to each rats' initial response to cocaine, response to a novel environment and central zone entries in an open-field. Locomotor sensitization demonstrated an inverse correlation with the initial cocaine response. In contrast, conditioned place preference demonstrated an inverse correlation with the centre response. These results demonstrate that the combination of the acute cocaine response and the centre response in a novel open field environment can be used to indicate the propensity of a given rat to exhibit either behavioral sensitization or conditioned place preference; however, it seems that sensitization and place preference are not necessarily co-expressed to a similar extent in the same individual animal.

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Section: Discussionmentioning

confidence: 99%

Simultaneous expression of cocaine-induced behavioral sensitization and conditioned place preference in individual rats

Seymour

Wagner

2008

Brain Research

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“…One of the most consistent behavioral findings has been that rats with lower, but not higher, initial responsiveness to cocaine [low cocaine responders (LCRs), but not high cocaine responders (HCRs)] more readily develop cocaine-induced locomotor sensitization after repeated noncontingent cocaine (10 mg/kg i.p.) (Sabeti et al, 2003;Allen et al, 2007;Mandt et al, 2008Mandt et al, , 2009Nelson et al, 2009). It is noteworthy that the LCR/HCR difference in cocaine-induced locomotor sensitization was not found to predict acquisition of low-dose cocaine self-administration (Mandt et al, 2008).…”

Section: Introductionmentioning

confidence: 94%

Cocaine Dose and Self-Administration History, but Not Initial Cocaine Locomotor Responsiveness, Affects Sensitization to the Motivational Effects of Cocaine in Rats

Mandt

Gomez²,

Johnston³

et al. 2012

J Pharmacol Exp Ther

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Cocaine addiction is a significant and complex disease. Part of this complexity is caused by the variability of the drug experience early in drug use (initial responsiveness, amount of use, etc.). In rats, individual differences in initial cocaine responsiveness and cocaine self-administration history both predict the development of cocaine sensitization, a putative mechanism contributing to the development of cocaine addiction. Here, we sought to determine the role of these factors and cocaine dose on the development of sensitization to cocaine's motivational effects during the earliest stages of self-administration. Rats were classified as either low or high cocaine responders (LCRs or HCRs, respectively) based on acute cocaine-induced locomotor activity (10 mg/kg i.p.) before learning to self-administer cocaine (0.6 mg/kg/infusion i.v.) under a fixed ratio 1 (FR1) schedule of reinforcement. After acquisition, rats self-administered cocaine (0.6 or 1.2 mg/kg/infusion) under a progressive ratio (PR) schedule of reinforcement either immediately or after an additional five FR1 sessions (0.6 or 1.2 mg/kg/infusion). No LCR/HCR differences in sensitization were observed. However, regardless of LCR/HCR classification, exposure to the higher dose of cocaine produced sensitization to cocaine's motivational effects on the PR schedule (i.e., increased break points) and an escalation of consumption on the FR schedule. Thus, our results reveal a novel model for studying escalation and sensitization very early after acquisition and suggest that sensitization may be important in the earliest stages of the cocaine addiction process.

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“…In this test, rats are categorized as HR or LR based on their locomotor response to acute cocaine. This individual difference is linked to dopamine transporter (DAT) function (Sabeti et al, 2003;Briegleb et al, 2004) and cocaine CPP (Allen et al, 2007). However, in contrast to the HR/LR test, high cocaine responders do not differ from low cocaine responders in acquisition of cocaine self-administration (Mandt et al, 2008(Mandt et al, , 2012.…”

Section: Preclinical Behavioral Neuropharmacologymentioning

confidence: 99%

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

2013

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Low and high locomotor responsiveness to cocaine predicts intravenous cocaine conditioned place preference in male Sprague–Dawley rats

Cited by 56 publications

References 40 publications

Simultaneous expression of cocaine-induced behavioral sensitization and conditioned place preference in individual rats

Simultaneous expression of cocaine-induced behavioral sensitization and conditioned place preference in individual rats

Cocaine Dose and Self-Administration History, but Not Initial Cocaine Locomotor Responsiveness, Affects Sensitization to the Motivational Effects of Cocaine in Rats

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

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