Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients

Abstract

Human immunodefiiency virus (HIV) infection and aquired immunodeficiency syndrome (AIDS)cause a progressive depletion of CD4 + T cell populations accompanied by progressive impairment of cellular immunity and increasing susceptibility to opportunistic infections. Seborrheic dermatitis is one of the most common skin opportunistic infections on HIV/AIDS patients. Malassezia species is bilieved as the causative of seborrheic dermatitis. The aim of the study was to evaluate low CD4 + T cell counts as risk factor for Malassezia sp. infection in HIV/AIDS patients. This was an observational study with cross-sectional design conducted on HIV/AIDS patients who attended in Department of Dermatology and Venereology, Faculty of Medicine Universitas Gadjah Mada/ Dr Sardjito General Hospital, Yogyakarta and met the inclusion and exclusion criteria. Culture of Malassezia sp. was conducted in Department of Microbiology and classified as high (>100 CFU/ tape) and low (<100 CFU/tape) density colonies. CD4 Sci, Volume 46,No. 4, CFU/tape. Tidak ada hubungan bermakna adalah kadar sel T CD4 + dengan jumlah koloni Malassezia sp dalam penelitian ini (p=0,607; 95%CI=0,(4)(5)19; RP=0,452). Dapat disimpulkan, kadar sel T CD4 + yang rendah bukan merupakan faktor terjadinya infeksi Malassezia sp. pada penderita HIV/AIDS.

Population dynamics of Malassezia species on the skin of HIV-infected patients

“…In our study, we did not observe a trend between CD 4 T cell count and Malassezia CFU count on the skin of HIVinfected patients. This is in agreement with other studies that have reported that there is no signi cant relationship between the CD 4 T cell count and the number of Malassezia CFU in HIV-infected patients (Panjaitan, Pudjiati and Siswati, 2014). While other authors demonstrated that there was a trend between numbers of Malassezia yeasts present on lesional skin, severity of seborrheic dermatitis and CD 4 T cell counts in HIV-positive patients (Schechtman, Hay and Midgley, 1995).…”

“…In our study, we did not observe a trend between CD 4 T cell count and Malassezia CFU count on the skin of HIVinfected patients. This is in agreement with other studies that have reported that there is no signi cant relationship between the CD 4 T cell count and the number of Malassezia CFU in HIV-infected patients(Panjaitan, Pudjiati and Siswati, 2014).…”

“…One hypothesis is the immune de ciency associated with HIV infection. However, the studies are con icting on this subject (Panjaitan, Pudjiati and Siswati, 2014;Forrestel et al, 2016;. In our study, we did not observe a trend between CD 4 T cell count and Malassezia CFU count on the skin of HIVinfected patients.…”