Low‐density‐lipoprotein peak particle size in a Mediterranean population

Rizzo, Manfredi; Barbagallo, Carlo M.; Severino, Maurizio; Polizzi, F; Onorato, Francesco; Noto, Davide; Cefalù, Angelo B.; Pace, Antonio; Marino, G.; Notarbartoló, A; Averna, Roberto

doi:10.1046/j.1365-2362.2003.01125.x

Cited by 40 publications

(4 citation statements)

References 38 publications

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“…Diabetic dyslipidemia is characterized by the elevated TG and sdLDL, decreased HDL-C and slightly elevated or normal LDL-C. A study shows that the ratio of sdLDL/LDL in healthy male adults is about 30% to 35%, whereas it reaches as high as 45% to 50% in diabetic subjects. [43,44] Similar results were reported in a Japanese study. [45] In our study, results showed no significant difference in LDL-C within the general population, but higher sdLDL was found in the diabetic subgroup.…”

Section: Discussionsupporting

confidence: 88%

PCSK9 positively correlates with plasma sdLDL in community-dwelling population but not in diabetic participants after confounder adjustment

et al. 2019

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This study aimed to investigate the relationship between plasma proprotein convertase subtilisin kexin 9 (PCSK9) and small dense low-density lipoprptein (sdLDL) in diabetic and non-diabetic participants in a community-dwelling cohort. The plasma levels of PCSK9 and sdLDL were detected in 1766 participants (median age: 61.40 years; 733 males vs 1033 females; 383 diabetic vs 1383 non-diabetic patients) from the Pingguoyuan community of Beijing, China. Results showed that Pearson correlation analysis revealed a positive correlation between PCSK9 and sdLDL ( r = 0.263, P < .001). Multiple linear regression analysis showed a significant positive correlation between plasma PCSK9 and sdLDL in the whole population study. sdLDL was used as the dependent variable, and the potential cofounders were adjusted. However, any independent relationship was not observed between circulating PCSK9 and sdLDL in the diabetic subpopulation ( r = 0.269, P < .05, β = 9.591, P > .05). Thus, there is a positive correlation between plasma PCSK9 and sdLDL in a community-dwelling cohort, but not in type 2 diabetic subpopulation, after confounder adjustment.

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Section: Discussionsupporting

confidence: 88%

PCSK9 positively correlates with plasma sdLDL in community-dwelling population but not in diabetic participants after confounder adjustment

et al. 2019

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“…Moreover, the prevalence of sdLDL among healthy non-diabetics in a small Mediterranean Island was determined to be 30 – 35% of total LDL-C in adult men. [ 34 ] This study reported 32% of LDL-C as sdLDL-C among non-diabetic men which is almost the same as the Mediterranean study. Among diabetes patients, a slightly higher prevalence of 50% was reported [ 34 ] which is higher than the 45% noted in this study.…”

Section: Discussionsupporting

confidence: 63%

Elevation of small, dense low density lipoprotein cholesterol—a possible antecedent of atherogenic lipoprotein phenotype in type 2 diabetes patients in Jos, North-Central Nigeria

et al. 2017

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BackgroundThe global prevalence of type 2 diabetes is increasing. Dyslipidaemia is a known complication of diabetes mellitus manifesting frequently as cardiovascular diseases and stoke. Elevation of small, dense low density lipoprotein has been recognised as a component of the atherogenic lipoprotein phenotype associated with cardiovascular complications. We speculate that the elevation of this lipoprotein particle may be the antecedent of the atherogenic lipoprotein phenotype. This study therefore aims to determine the pattern of dyslipidaemia among diabetes mellitus patients in Jos, North-Central Nigeria.MethodsOne hundred and seventy-six patients with type 2 diabetes and 154 age-matched controls were studied. The patients with diabetes were regular clinic attenders and had stable glycaemic control. None were on lipid-lowering therapy. Anthropometric indices, blood pressure, and lipids (including total cholesterol, high density lipoprotein cholesterol, and triglyceride) were measured by chemical methods using the Hitachi 902 analyzer. Low density lipoprotein cholesterol was calculated using the Friedewald’s equation. Small, dense low density lipoprotein cholesterol, −sdLDL-C was measured using the precipitation method by Hirano et al. Means of the different groups were compared using EPI Info and a P-value of <0.05 was accepted as significant difference.ResultsTotal cholesterol, low density lipoprotein cholesterol, triglyceride and small, dense lipoprotein cholesterol were all significantly higher in diabetes patients than controls except high density lipoprotein cholesterol. The percentage of LDL-C as sdLDL-C among the diabetes versus control group was 45% ± 17.79 v 32.0% ± 15.93. Serum sdLDL-C concentration was determined to be 1.45 ± 0.64 among diabetes patients and 0.8 ± 0.54 among control subjects. 75% of diabetes patients had hypertension and were taking blood pressure lowering medications.ConclusionThe classical atherogenic lipoprotein phenotype was not demonstrated among subjects with type 2 diabetes mellitus in this study, but the elevation of serum small dense low density lipoprotein cholesterol in patients with sustained hypertension suggests the establishment of atherogenic complications among our diabetes patients.

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“…Furthermore, since the immediate pre-MI, LDL-cholesterol levels were not available, we cannot rule out the possibility that prior to MI these values were higher than after the MI event. Triglycerides levels have been reported to increase small, dense LDL particles and therefore the risk of cardiovascular disease [58, 59]. In the present study, however, a significant difference is not observed.…”

Section: Discussioncontrasting

confidence: 82%

“…The exclusion of this outlier from the analysis did not alter the distribution of these data or result in a significant difference in triglyceride levels between the 2 groups. Since there is no difference between groups in triglyceride levels, the hypothesized difference in the LDL subfraction profile in our 2 groups may be mediated by other factors such as smoking [58-60]. In contrast to the above hypotheses, no correlation was observed between smoking and triglyceride level in this study, or between MI occurrence and triglyceride level.…”

Section: Discussioncontrasting

confidence: 60%

Low HDL Cholesterol, Smoking and IL-13 R130Q Polymorphism are Associated with Myocardial Infarction in Greek Cypriot Males. A Pilot Study

Xenophontos¹,

Hadjivassiliou²,

Karagrigoriou³

et al. 2008

TOCMJ

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This study was carried out in Greek Cypriot males to identify risk factors that predispose to myocardial infarction (MI). Genetic and lipid risk factors were investigated for the first time in a Greek Cypriot male case-control study.Contrary to other studies, mean low density lipoprotein cholesterol did not differ between cases and controls. High density lipoprotein cholesterol on the other hand, although within normal range in cases and controls, was significantly higher in the control population. In agreement with many other studies, smoking was significantly more prevalent in cases compared with controls. In pooled cases and controls, smokers had a significantly lower HDL-C level compared with non-smokers. The frequency of the IL-13 R130Q homozygotes for the mutation (QQ), as well as the mutant allele were significantly higher in cases compared with controls. The IL-13 R130Q variant, or another locus, linked to it, may increase the risk of MI.

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Low‐density‐lipoprotein peak particle size in a Mediterranean population

Cited by 40 publications

References 38 publications

PCSK9 positively correlates with plasma sdLDL in community-dwelling population but not in diabetic participants after confounder adjustment

PCSK9 positively correlates with plasma sdLDL in community-dwelling population but not in diabetic participants after confounder adjustment

Elevation of small, dense low density lipoprotein cholesterol—a possible antecedent of atherogenic lipoprotein phenotype in type 2 diabetes patients in Jos, North-Central Nigeria

Low HDL Cholesterol, Smoking and IL-13 R130Q Polymorphism are Associated with Myocardial Infarction in Greek Cypriot Males. A Pilot Study

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