Low diversity of gut microbiota in the early phase of post-bone marrow transplantation increases the risk of chronic graft-versus-host disease

Konishi, Tatsuya; Kusakabe, Shinsuke; Hino, Akihisa; Inamoto, Kyoko; Yoshifuji, Kota; Kiridoshi, Yuko; Takeshita, Kozue; Sasajima, Satoshi; Toya, Takashi; Igarashi, Aiko; Najima, Yuho; Kobayashi, Takeshi; Doki, Noriko; Motooka, Daisuke; Nakamura, Shota; Suyama, Masahiro; Suda, Wataru; Shiota, Atsushi; Atarashi, Koji; Hattori, Masahira; Honda, Kenya; Yokota, Takafumi; Ohashi, Kazuteru; Shibayama, Hirohiko; Fukushima, Kentaro; Kakihana, Kazuhiko

doi:10.1038/s41409-021-01249-2

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Low diversity of gut microbiota in the early phase after bone marrow transplantation increases the risk of GVHD and mortality. 40,41 Our study observed GVHD in three children, but there are limited data on the relationship between the gut mycobiome and GVHD. In the only study in this area, Van der Velden et al 42 reported that colonization with Paneth cell damage and decreased α-defensin release.…”

Section: Microbiota Composition Has Been Previously Performed In Allo-mentioning

confidence: 82%

Intestinal mycobiota composition and changes in children with thalassemia who underwent allogeneic hematopoietic stem cell transplantation

Yalçin

Aksu

Kuşkonmaz

et al. 2021

Pediatric Blood & Cancer

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Background: Allogeneic hematopoietic stem cell transplantation (HSCT) alters the diversity of the intestinal bacterial microbiota. This study aimed to evaluate human mycobiota composition pre-HSCT and post-HSCT in children with thalassemia.Method: Ten children with thalassemia undergoing allogeneic HSCT were enrolled.The stool samples were collected before the transplantation regimen, before the transplant day, and +15, +30 days, and three months after transplantation. Stool samples were also collected from the donor and the patient's caregivers. Gut mycobiota composition was evaluated with metagenomic analysis.Results: Pretransplant mycobiota of children with thalassemia (the predominant genus was Saccharomyces, 64.1%) has been shown to approximate the diverse mycobiota compositions of healthy adult donors but becomes altered (lower diversity) following transplant procedures. Three months after HSCT, phyla Ascomycota and Basidiomycota were 83.4% and 15.6%, respectively. The predominant species were Sacc-aharomyces_uc and Saccharomyces cerevisiae (phylum Ascomycota); we also observed Malassezia restricta and Malassezia globosa (phylum Basidiomycota) (∼13%). On day 90 after HSCT, we observed 65.3% M. restricta and 18.4% M. globosa predominance at the species level in a four-year-old boy with acute graft-versus-host disease (GVHD) (skin and gut involvement) 19 days after transplantation included. Conclusion:The mycobiota composition of children with thalassemia altered after HSCT. We observed Malassezia predominance in a child with GVHD. Further studies in children with GVHD will identify this situation.

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Section: Microbiota Composition Has Been Previously Performed In Allo-mentioning

confidence: 82%

Intestinal mycobiota composition and changes in children with thalassemia who underwent allogeneic hematopoietic stem cell transplantation

Yalçin

Aksu

Kuşkonmaz

et al. 2021

Pediatric Blood & Cancer

View full text Add to dashboard Cite

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Nutritional Considerations of Critically Ill Hematopoietic Cell Transplantation Patients

Fuji

Cheng

2023

Pulmonary and Critical Care Considerations of Hematopoietic Stem Cell Transplantation

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The association of intestinal microbiota diversity and outcomes of allogeneic hematopoietic cell transplantation: a systematic review and meta-analysis

Wang,

Yue,

Zhou

et al. 2023

Ann Hematol

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Low diversity of gut microbiota in the early phase of post-bone marrow transplantation increases the risk of chronic graft-versus-host disease

Cited by 3 publications

References 12 publications

Intestinal mycobiota composition and changes in children with thalassemia who underwent allogeneic hematopoietic stem cell transplantation

Intestinal mycobiota composition and changes in children with thalassemia who underwent allogeneic hematopoietic stem cell transplantation

Nutritional Considerations of Critically Ill Hematopoietic Cell Transplantation Patients

The association of intestinal microbiota diversity and outcomes of allogeneic hematopoietic cell transplantation: a systematic review and meta-analysis

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