Low doses of methylmercury intoxication solely or associated to ethanol binge drinking induce psychiatric-like disorders in adolescent female rats

Belém-Filho, Ivaldo Jesus Almeida; Ribera, Paula Cardoso; Nascimento, Aline L.; Gomes, Antônio Rafael Quadros; Lima, Rafael Rodrigues; Crespo-López, María Elena; Monteiro, Marta Chagas; Fontes-Júnior, Enéas Andrade; Lima, Marcelo de Oliveira; Maia, Cristiane do Socorro Ferraz

doi:10.1016/j.etap.2018.04.021

Cited by 24 publications

(55 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regards emotionality, we also found that this same pattern display anxiogenic and depressant phenotype in adult rats. Our previous data on adolescent individuals have reported such psychiatric-like conditions [9,10], however, this is the first time that we demonstrated that sequential binge drinking pattern (5 cycles of 3 on-4 off) during adolescence until early-adult life induces anxiogenic-and depressant-like behavior in rodents.…”

Section: Oxidative Medicine and Cellular Longevitymentioning

confidence: 60%

“…All administrations were performed by oral gavage with orogastric cannula (Insight, Brazil). It was classified as binge the pattern of three followed administrations of ethanol per week, once per day [9]. Three groups were used: control, untreated, and treated individuals.…”

Section: Preparation Of Aqueous Extract Of Ganoderma Lucidum (Aegl)mentioning

confidence: 99%

“…The test was videotaped for further analysis by ANY-maze TM (Stoelting, USA). The motor parameters (i.e., total distance traveled and number of rearing) were measured [9]. Briefly, 2970 μL of working solution was added to the cuvette, followed by reading the absorbance spectrophotometer.…”

Section: Open Field Test (Of)mentioning

confidence: 99%

See 2 more Smart Citations

Ganoderma lucidumAmeliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking

Nascimento

Luz

Silva

et al. 2020

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. Besides, these mushroom bioactive compounds present antioxidant and anti-inflammatory activities. On the side, binge drinking paradigm consists of ethanol exposure that reflects the usual consumption of adolescents, which elicits deleterious effects, determined by high ethanol consumption, in a short period. In this study, we investigated whether the Aqueous Extract of G. lucidum (AEGl) reduces the behavioral disorders induced by alcohol. Male (n=30) and female Wistar rats (n=40), seventy-two days old, were used for behavioral/biochemical and oral toxicity test, respectively. Animals were exposed to 5 binges (beginning at 35 days old) of ethanol (3 g/kg/day) or distilled water. Twenty-four hours after the last binge administration, animals received AEGl (100 mg/kg/day) or distilled water for three consecutive days. After treatment protocol, open field, elevated plus maze, forced swim, and step-down inhibitory avoidance tests were performed. Oxidative stress parameters were measured to evaluate the REDOX balance. Our results demonstrated that AEGl elicited the recovery of spontaneous horizontal exploration capacity, anxiogenic- and depressive-profile, as well as short-term memory damage induced by binge-ethanol exposure. The behavioral effects of the extract were associated to the reequilibrium of the animals’ REDOX balance. Thus, AEGl, a medicinal mushroom, ameliorates behavioral alteration on a model of motor, cognitive and psychiatric-like disorders induced by binge drinking paradigm and emerges as a useful tool as a food supplement in the management of disorders of alcoholic origin.

show abstract

Section: Oxidative Medicine and Cellular Longevitymentioning

confidence: 60%

Section: Preparation Of Aqueous Extract Of Ganoderma Lucidum (Aegl)mentioning

confidence: 99%

See 1 more Smart Citation

Ganoderma lucidumAmeliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking

Nascimento

Luz

Silva

et al. 2020

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

show abstract

“…(4) Content of Thiol Groups . The content of thiol groups was based on the ability to reduce 5,5-dithiobis-2-nitrobenzoic acid (DTNB) for nitrobenzoic acid (TNB), wherein haemolysed blood samples (20 μ L) were solubilized with distilled water plus PBS/EDTA (4 mL) and mixed by vortexing according to Belém-Filho et al's [ 11 ] protocol. After this, 3 mL of samples was quantitated by spectrophotometry at 412 nm and the content of the thiol groups were expressed in μ g/mL, as described by Riddles et al [ 48 ].…”

Section: Methodsmentioning

confidence: 99%

“…Actually, our group has been focusing on alcohol versus adolescence versus female gender, through a heavy-drinking protocol [ 6 – 10 ] or a binge-drinking paradigm [ 11 – 14 ]. In this regard, we showed that heavy chronic EtOH intoxication (6.5 g/kg/day during 55 days) during adolescence induced neuronal loss and an expressive reduction in astrocytes in the cerebral cortex of rats [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Repeated Cycles of Binge‐Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood

Fernandes

Lopes

Santana

et al. 2018

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

Moderate ethanol consumption (MEC) is increasing among women. Alcohol exposure usually starts in adolescence and tends to continue until adulthood. We aimed to investigate MEC impacts during adolescence until young adulthood of female rats. Adolescent female Wistar rats received distilled water or ethanol (3 g/kg/day), in a 3 days on-4 days off paradigm (binge drinking) for 1 and 4 consecutive weeks. We evaluate liver and brain oxidative damage, peripheral oxidative parameters by SOD, catalase, thiol contents, and MDA, and behavioral motor function by open-field, pole, beam-walking, and rotarod tests. Our results revealed that repeated episodes of binge drinking during adolescence displayed lipid peroxidation in the liver and brain. Surprisingly, such oxidative damage was not detectable on blood. Besides, harmful histological effects were observed in the liver, associated to steatosis and loss of parenchymal architecture. In addition, ethanol intake elicited motor incoordination, bradykinesia, and reduced spontaneous exploratory behavior in female rats.

show abstract

A New Chemically Modified Carbon Paste Electrode Derived from Aloe Vera Xanthate Nanoparticles to Detect Mercury Ions

Muthukumaran

Basha²,

Venkatachalam

et al. 2021

Electroanalysis

View full text Add to dashboard Cite

This environmentally benign work describes a simple electrochemical sensor constructed with a chemically modified carbon paste electrode (CMCPE) using aloe vera xanthate nanoparticles to detect mercury ions. The characterization and morphology of nanoparticles were thoroughly investigated using modern techniques. The CMCPE efficiently senses the mercury ions. The limit of detection of mercury ions wasexcellent to the order of 0.231 μg mL−1. Real‐time sample analysis showed promising results. The recovery range was between 99.4 % and 101.7 %. The activity of CMCPE was commendable even after fifty days.

show abstract

Low doses of methylmercury intoxication solely or associated to ethanol binge drinking induce psychiatric-like disorders in adolescent female rats

Cited by 24 publications

References 96 publications

Ganoderma lucidumAmeliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking

Ganoderma lucidumAmeliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking

Repeated Cycles of Binge‐Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood

A New Chemically Modified Carbon Paste Electrode Derived from Aloe Vera Xanthate Nanoparticles to Detect Mercury Ions

Contact Info

Product

Resources

About