Low Incidence of Minor Myocardial Damage Associated with Coronary Stenting Detected by Serum Troponin T Comparable to That with Balloon Coronary Angioplasty.

Ohnishi, Nobuhiko; Iwasaki, Kohichiro; Kusachi, Shozo; Hirami, Ryoichi; Matano, Sakae; Ohnishi, Hiromichi; Takeda, Kenji; Kita, Toru; Sakakibara, Noburu; Tsuji, Takao

doi:10.1536/ihj.39.139

Cited by 9 publications

(10 citation statements)

References 16 publications

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“…Various results with respect to the incidence of TnT release after elective coronary angioplasty have been reported. [16][17][18][19] The incidence of TnT release exceeding the cut-off point in the control group of our study was 42%, which is similar to that (44%) reported by Karim, et al 16) but higher than those (13% and 8.9%, respectively) reported by Shyu, et al 17) and Ohnishi, et al 19) The difference in the incidence of TnT release may be due to the difference in the total balloon inflation time during angioplasty. 18) Intracoronary pressure-derived CFI has often been used for evaluating coronary collateral function during coronary angioplasty.…”

Section: Discussionsupporting

confidence: 83%

“…However, other similar studies followed TnT levels in patients undergoing elective coronary angioplasty for more than 24 hours. [16][17][18][19] The peak values of TnT elevation may have been seen after an 18-hour rest period in this study. The stenotic lesion was located in one of the three major coronary arteries, therefore, some potential differences in TnT release due to the lesion site were not considered.…”

Section: Vol 43 Nomentioning

confidence: 48%

“…15) Several studies have shown that TnT elevation is observed in some patients undergoing elective coronary angioplasty, indicating that the elevation reflects minor myocardial damage. [16][17][18][19] Moreover, TnT has been shown to be more sensitive and specific than creatine kinase-MB for the detection of myocardial damage after angioplasty. 16,17) The aim of the present study was to examine the preconditioning effect of nicorandil on TnT release after coronary angioplasty in patients with stable angina pectoris.…”

mentioning

confidence: 99%

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Nicorandil-Induced Preconditioning as Evidenced by Troponin T Measurements after Coronary Angioplasty in Patients with Stable Angina Pectoris.

et al. 2002

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SUMMARYNicorandil has been reported to have a preconditioning effect which suppresses the ST-segment shift or lactate production during coronary angioplasty in patients with stable angina pectoris. The present study investigated whether the preconditioning effect of nicorandil affects troponin T (TnT) levels after coronary angioplasty. Twenty-four patients with stable angina pectoris were randomized to receive a 1-minute intravenous infusion of nicorandil (100 µg/kg) or normal saline. Five minutes later they underwent three 2-minute balloon inflations 5 minutes apart. The sum of ST-segment elevation in all leads (∑ST) was determined at the end of each balloon inflation. Serum levels of TnT were measured 6 and 18 hours after the procedure, and the higher value of the two measurements was compared between the groups. ∑ST decreased progressively during the three sequential balloon inflations in both groups and was less in the nicorandil group than in the control group. The TnT level after the procedure was significantly lower in the nicorandil group than in the control group (0.05±0.05 vs 0.11±0.10 ng/mL). In conclusion, pretreatment with intravenous nicorandil suppresses TnT release after coronary angioplasty as well as ST-segment elevation during coronary angioplasty, suggesting pharmacological preconditioning by nicorandil. (Jpn Heart J 2002; 43: 443-453)

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Section: Discussionsupporting

confidence: 83%

Section: Vol 43 Nomentioning

confidence: 48%

mentioning

confidence: 99%

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Nicorandil-Induced Preconditioning as Evidenced by Troponin T Measurements after Coronary Angioplasty in Patients with Stable Angina Pectoris.

et al. 2002

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“…Troponin is one of the reliable metabolic markers of myocardial injury . Several studies have shown that troponin elevation is observed in some patients undergoing elective PCI, indicating that the elevation reflects minor myocardial damage . Moreover, troponin has been shown to be more sensitive and specific than creatine kinase‐MB isoenzyme (CK‐MB) for detection of myocardial damage after angioplasty .…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Effects of Oral Nicorandil Use in Diabetic Patients Undergoing Elective Percutaneous Coronary Intervention

Shehata

2014

J Interven Cardiology

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“…Troponin I is a highly specific marker for myocyte injury and its sensitivity is high even in minor myocardial damage (Ohnishi et al 1998). Numerous studies have shown that the plasma troponin levels of pregnant women increase in myocardial damage due to syndromes such as cocaine use and acute coronary syndrome (Livingston et al 2000;Nabatian et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Cardiac troponin levels in pregnant women with severe pre-eclampsia

Çetin¹,

Baloğlu²,

Çetinkaya³

et al. 2009

Journal of Obstetrics and Gynaecology

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Pre-eclampsia is a multisystem disorder that involves vascular endothelial dysfunction and diffuse inflammatory response. The cardiac troponin (cTn-I) levels in pre-eclampsia are controversial. The objective of this study was to compare the cTn-I levels between normal pregnant women and those with severe pre-eclampsia. A total of 78 patients who underwent caesarean section were included in the study. The patients were assigned into two groups as the severe pre-eclamptic pregnant group (study group, n = 36) and normotensive pregnant group (control group, n = 42).The cTn-I levels of all patients were measured preoperatively and postoperatively. A statistically significant difference was not determined between the preoperative and postoperative cTn-I levels (p > 0.05) between the two groups. In the present study, a relation was not determined between pre-eclampsia and increased cTn-I levels. If high cTn-I levels are determined in pre-eclamptic patients, other pathologies that may cause myocardial damage should be investigated.

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Low Incidence of Minor Myocardial Damage Associated with Coronary Stenting Detected by Serum Troponin T Comparable to That with Balloon Coronary Angioplasty.

Cited by 9 publications

References 16 publications

Nicorandil-Induced Preconditioning as Evidenced by Troponin T Measurements after Coronary Angioplasty in Patients with Stable Angina Pectoris.

Nicorandil-Induced Preconditioning as Evidenced by Troponin T Measurements after Coronary Angioplasty in Patients with Stable Angina Pectoris.

Cardioprotective Effects of Oral Nicorandil Use in Diabetic Patients Undergoing Elective Percutaneous Coronary Intervention

Cardiac troponin levels in pregnant women with severe pre-eclampsia

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