Low-level laser therapy (LLLT) improves alveolar bone healing in rats

Ribeiro, Larissa Nogueira Soares; Figueiredo, Fellipe Augusto Tocchini de; Mira, Paôla Caroline da Silva; Arnez, Maya Fernanda Manfrin; Matsumoto, Mírian Aiko Nakane; Menezes, Luciane Macedo de; Küchler, Érika Calvano; Stuani, Maria Bernadete Sasso

doi:10.1007/s10103-021-03340-y

Cited by 10 publications

(5 citation statements)

References 54 publications

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“…Furthermore, in osteogenic aspects, LLLT irradiation (gallium-aluminumarsenide diode; λ 830 nm, 30 mW, θ 1 mm) showed almost two-times greater bone formation rate with new bone structural unit in histometric analysis (13.29% vs. 26.17%). And also, comparing the control group, almost two times of collagen formation and five times of osteoblast expression (RUNX2) was shown [51]. In angiogenic aspects, LLLT irradiation (λ 660 or 780 nm, 40 mW, θ 4 mm) quantitatively expressed almost two times number of vessels.…”

Section: Photobiomodulation Therapy For Bone Regenerationmentioning

confidence: 88%

Application of photobiomodulation therapy in the recovery of a fracture model in different countries: a concise review

Kim

Padalhin²

2022

Medical Lasers

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The bone is a dynamic biological tissue composed of metabolically active cells which are integrated into a hard framework. However, it can be injured due to trauma or infections and this can result in bone defects. Hence, bone generation or bone healing has been an interesting field of orthopedics and has been the subject of multiple studies. As a result, various substances which promote osteogenesis and angiogenesis have been identified, but their mechanism of action has not yet been completely elucidated. Owing to its anti-inflammatory and wound-healing effects, photobiomodulation (PBM) has been proposed in the treatment of various disease conditions. Specifically, in orthopedics, multiple studies have been conducted to treat bone generation or bone union using PBM. The clinical improvement of bone healing as well as various substances and mechanisms of osteogenesis and angiogenesis by PBM have been identified although the mechanism of action is not fully understood. This review summarizes the published reports on the bone healing effects of PBM treatment in fracture sites.

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Section: Photobiomodulation Therapy For Bone Regenerationmentioning

confidence: 88%

Application of photobiomodulation therapy in the recovery of a fracture model in different countries: a concise review

Kim

Padalhin²

2022

Medical Lasers

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“…It has also been demonstrated to stimulate bone formation in large calvaria defects of ovariectomized rats (3). In a recent immunohistochemical study, LLLT administration led to an increase in bone formation, collagen synthesis (55), bone metabolism, tooth movement (56), angiogenesis, and osteoid formation (57). Therefore, the observed increase in mechanical strength may be attributed to an increase in collagen content.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Effects of Low-level Laser Therapy and Platelet-rich Plasma on Bone Calcium Content and Mechanical Properties at Tooth Extraction Sites: An Animal Study

Sharifi¹,

Tanideh²,

Zadeh³

et al. 2023

Shiraz E-Med J

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Background: Both low-level laser therapy (LLLT) and platelet-rich plasma (PRP) are demonstrated to promote the repair of mandibular defects. Objectives: This study investigated the mechanical properties and calcium content at the tooth extraction site in a rat model exposed to LLLT (λ = 808 nm) with or without PRP. Methods: In this experimental rat model study, the left first molar maxillary teeth were extracted in twenty male rats. Then, the animals were randomly divided into four groups. Group one: after extraction, the extraction sockets were treated with 0.9 W gallium-aluminum-arsenide (GaAlAs) diode laser irradiation for five minutes every 72 hours for the next 12 days (4 times overall); group two: PRP was placed in the extraction sockets; group three: a combination of both treatments (LLLT+PRP) was applied; group four: the extraction sockets remained untreated (the control group). All rats were sacrificed 30 days post-operative. All bone blocks of the extracted socket were prepared for mechanical strength and calcium content analyses. Mann-Whitney test, one-way ANOVA test, and post hoc Fisher’s least significant difference (LSD) were used to analyze the data. A P-value less than 0.05 was considered significant. All analyses were performed by SPSS 16.0. The graph is illustrated in the graph pad 5. Results: The compressive strength in the laser group was significantly higher than in the control and PRP-treated groups (P = 0.0001 and 0.00044, respectively). Compared to the control and PRP groups, the effects of a combination of PRP and LLLT mechanical strength were statistically similar. Calcium content was influenced by none of the treatments. Conclusions: The mechanical strength of the bone blocks was significantly stronger in the LLLT group than in the other groups. PRP alone or combined with LLLT demonstrated a synergistic impact on neither mechanical strength nor calcium content.

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“…It is widely accepted today that inflammation and bone resorption are basic responses of periodontal tissue to damage. LLLT reduces gingival inflammation, and many studies indicate that LLLT has capacity to alter bone cellular behaviour [8,11]. Faster callus formation, revascularization, promotion of bone formation and denser trabecular networks have also been reported [12].…”

Section: Discussionmentioning

confidence: 99%

Low-level laser efficiency in reparation of bone defects

et al. 2023

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Introduction/Objective. Bone resorption is a common problem in dentistry, and bone reparation cannot be easily achieved. Several techniques of bone grafting and the use of low-level laser treatment (LLLT) as a new therapeutic optional recommended for improving bone repair were applied. The aim of the study was to investigate the influence of LLLT in bone repair of artificially made bone defects in the rat mandible using histomorphometry. Methods. The research was carried out on 60 female rats. Bone defects were made in the mandible, and animals were divided into two groups, each containing 30 animals. In the study group, the implantation site was submitted to GaAlAs laser irradiation 670nm, 5 mW, 4 min/per day for 5 days. The control group had no postoperative treatment. Animals were sacrificed after two, six, and eight weeks post LLLT, and preparations were analysed by histomorphometry, determining bone area fraction, bone area, integral density, mean density, and density variation. Results. Histomorphometric analysis revealed statistically higher values of area fraction, area, and integral density in the study group after two and six weeks. However, no beneficial laser effect was noticed after eight weeks. Conclusion. Low-level lasers have a stimulating effect on reparatory mechanisms in the early regeneration stage of artificially made bone defects in the rat mandible and can be used as a useful helping method in bone treatment.

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Low-level laser therapy (LLLT) improves alveolar bone healing in rats

Cited by 10 publications

References 54 publications

Application of photobiomodulation therapy in the recovery of a fracture model in different countries: a concise review

Application of photobiomodulation therapy in the recovery of a fracture model in different countries: a concise review

Evaluating the Effects of Low-level Laser Therapy and Platelet-rich Plasma on Bone Calcium Content and Mechanical Properties at Tooth Extraction Sites: An Animal Study

Low-level laser efficiency in reparation of bone defects

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