Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients

Abstract

PurposePopulation-based studies have revealed a high prevalence of cognitive impairment after stroke. We aimed to determine the impact of serum magnesium (Mg2+) levels on the occurrence of poststroke cognitive impairment (PSCI).Patients and methodsAcute ischemic stroke patients (n = 327) were enrolled in our study and serum Mg2+ levels were assessed on admission. The cognitive performance of each patient was evaluated using the Mini–Mental State Examination (MMSE) at a 1-month follow-up visit.ResultsOne hundred five (32.1%) patients were diagnosed with PSCI at 1-month poststroke. The serum Mg2+ levels in both the PSCI group and the non-PSCI group were significantly lower than those in normal control group (P<0.001). In addition, the PSCI group had lower levels of serum Mg2+ compared to the non-PSCI group (P=0.003). In the binary logistic regression analysis, a serum Mg2+ level of ≤0.82 mmol/L was significantly associated with an increased risk of developing PSCI by the 1-month follow-up (OR 2.236, 95% CI 1.232–4.058, P=0.008), as was age (OR 1.043, 95% CI 1.014–1.073, P=0.003).ConclusionOur results demonstrate the existence of a significant association between low levels of serum Mg2+ and the occurrence of PSCI 1-month poststroke, and these results suggest that low levels of serum Mg2+ on admission may serve as a risk factor for developing PSCI by 1-month poststroke.

Higher Habitual Nuts Consumption Is Associated with Better Cognitive Function among Qatari Adults

“…The findings of our study were consistent with the results of most of the previous studies in both humans and animals [7][8][9][10][11][12][13][14][15][16][23][24][25][26]. A cross-sectional study conducted in…”

“…The findings of our study were consistent with the results of most of the previous studies in both humans and animals [7][8][9][10][11][12][13][14][15][16][23][24][25][26]. A cross-sectional study conducted in Spain on 447 participants found that increased intake of Mediterranean-diet components including walnuts is linked to better cognitive function and increased working memory in elderly at high cardiovascular risk [27].…”

Serum Magnesium and Cognitive Function Among Qatari Adults

“…In a case-control study of 30 patients (15 with Alzheimer's disease and 15 with mild cognitive impairment) and 15 control participants, lower magnesium concentrations were found among patients with Alzheimer's disease and mild cognitive impairment (Balmus et al, 2017). Evidence from animal studies supports a link between circulating magnesium and cognition (Slutsky et al, 2010;Li et al, 2014;Huang et al, 2018;Tu et al, 2018). Low magnesium impairs cognition (Tu et al, 2018) and FIGURE 2 | Interaction between serum magnesium concentrations, diabetes, and gender with cognition.…”

“…Evidence from animal studies supports a link between circulating magnesium and cognition (Slutsky et al, 2010;Li et al, 2014;Huang et al, 2018;Tu et al, 2018). Low magnesium impairs cognition (Tu et al, 2018) and FIGURE 2 | Interaction between serum magnesium concentrations, diabetes, and gender with cognition. Values represent the adjusted mean (SD) of MRT derived from multivariable linear regression.…”

“…The findings are supported by the fact that Alzheimer's disease patients have lower plasma magnesium concentrations (Barbagallo et al, 2011). In stroke patients, low serum magnesium concentrations were associated with post-stroke cognitive impairment (Tu et al, 2018). However, the relation between magnesium and cognitive function in the general population is not clear.…”