Low molecular weight derivatives of different carrageenan types and their antiviral activity

Kalitnik, A. A.; Barabanova, A. O.; Nagorskaya, V. P.; Реунов, А. В.; Глазунов, В. П.; Соловьева, Т. Ф.; Yermak, Irina M.

doi:10.1007/s10811-012-9839-8

Cited by 92 publications

(63 citation statements)

References 36 publications

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“…Hydrolysis was carried out according to the method described by Kalitnik et al (2013). Polysaccharide sample (100 mg) was dissolved in 50 mL 0.1 N HCl and heated at 37 • C for 50 h. Hydrolysis was stopped by the addition of some drops of 0.1 N NH 4 OH solution to pH 8-9.…”

Section: Mild Acid Hydrolysismentioning

confidence: 99%

“…Currently, the mild acid hydrolysis method that proceeds without the destruction of 3,6-anhydrogalactose and leads to the formation of oligosaccharides with even and odd numbers of monosaccharide residues is often performed for the study of polysaccharides with a complex structures containing 3,6-anhydrogalactose (Yang et al, 2009). It was previously established that the more favourable conditions for the hydrolysis of kappa-carrageenan, containing 22% sulfate groups with 0.1 N hydrochloric acid were 37 • C and 24 h since the 3,6-anhydrogalactose in this case is preserved to a greater degree in comparison to standard conditions (60 • C and 4 h) (Kalitnik et al, 2013). The investigated polysaccharide was iota/kappa-carrageen which contained 32% sulphate groups.…”

Section: Mild Acid Hydrolysis Of the Polysaccharide From A Flabellifmentioning

confidence: 99%

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Structural analysis and cytokine-induced activity of gelling sulfated polysaccharide from the cystocarpic plants of Ahnfeltiopsis flabelliformis

Kravchenko

Anastyuk

Sokolova

et al. 2016

Carbohydrate Polymers

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Section: Mild Acid Hydrolysismentioning

confidence: 99%

Section: Mild Acid Hydrolysis Of the Polysaccharide From A Flabellifmentioning

confidence: 99%

Structural analysis and cytokine-induced activity of gelling sulfated polysaccharide from the cystocarpic plants of Ahnfeltiopsis flabelliformis

Kravchenko

Anastyuk

Sokolova

et al. 2016

Carbohydrate Polymers

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“…Large molecular size of κ-carrageenan have limited applications as it is insoluble in water and it forms viscous solution. Converting the High Molecular Weight Fraction of carrageenan (HMWF) into Low Molecular Weight of carrageenan (LMWF) will construct the bioavailability and enlarge the potential uses of carrageenan in pharmaceutical and biomedical [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Chemical and Spectral Characterization of The Ozonation Products of κ-Carrageenan

et al. 2018

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Abstract. Kappa (κ-) carrageenan oligomers are known to have several biological activities. Recent progress in the development of modified κ-carrageenan has resulted low molecular of κ-carrageenan. Ozone is a powerful oxidant and considered for depolymerization of κ-carrageenan. However, few studies have investigated the changes in κ-carrageenan properties associated with ozone treatment. This study would investigate on the changes in chemical structure after ozonation process. The experiments were carried out in a glass reactor equipped with an ozone bubble diffuser. Ozone with concentration of 80 ± 2 was bubbled into the solution. The ozone treatment was conducted at different times, i.e., 0 (control), 5, 10, 15, and 20 minutes. The experiments were conducted at pH 7 and constant stirring speed (200 rpm). Ozone-treated κ-carrageenan was dried at 60 o C for 24 h in a forced air oven. The chemical and spectral analyses of κ-carrageenan after ozonation process were carried out using UV-Vis and FT-IR spectroscopy. These changes are seen in the UV spectra as a high intensity of absorbance peak at 290 nm. It is shows that ozonation of κ-carrageenan leads to some chemical changes such as the formation of carbonyl, carboxyl or double bonds.The FT-IR spectra reveals that the chemical structure of degraded κ-carrageenan, in term of sulfate content, is only slightly affected by the ozone treatment.

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“…The high-molecular-weight (HMW) κ-carrageenan has limited applications as it is insoluble in water and it forms a viscous solution. By changing HMW -carrageenan into low molecular weight (LMW), -carrageenan increases the bioavailability and its potential applications for biomedical applications [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…LMW carrageenans have been produced by thermal depolymerization [20], acid hydrolysis [6,16,[21][22][23][24][25] and enzymatic hydrolysis [12,13,15,26,27]. There were several different techniques, such as microwave-assisted depolymerization [28], sonication [29][30][31], irradiation [17,32], and oxidation using H2O2 [21,33].…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Oxidative Depolymerization of κ-carrageenan by Ozone

Prasetyaningrum

Ratnawati

Jos

2017

Bull. Chem. React. Eng. Catal.

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Depolymerization kinetics of κ-carrageenan by ozone treatment has been studied at various pHs and times. The purified κ-carrageenan with the initial molecular weight of 271 kDa was dispersed in water to form (1 % w/v) solution. Ozone with 80±2 ppm concentration and constant flow rate of 3 L.min -1 was bubbled into the κ-carrageenan solution. The experiments were conducted at pH of 3, 7, and 10 at different times (5, 10, 15, and 20 minutes) of ozonation. The viscosity of the solution was measured using Ubbelohde capillary viscometer, which was then used to find the number-average molecular weight by Mark-Houwink equation. The number-average molecular weight data was treated using zero, first, and the second-order reaction kinetics model, to obtain the kinetics of κ-carrageenan depolymerization. The depolymerization is assumed to occur by random scission. The results show that the kinetics rate constant of κ-carrageenan depolymerization is higher at lower pHs. The second-order model is more suitable for describing the kinetics of depolymerization of κ-carrageenan by ozonation process. The rate constants for the second-order kinetics model are 5.45×10 -4 min -1 , 1.27×10 -4 min -1 , and 7.21×10 -5 min -1 for pH 3, 7, and 10, respectively. The actual values of reaction order under acid and alkali conditions are ranging from 1.88 to 1.90.

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Low molecular weight derivatives of different carrageenan types and their antiviral activity

Cited by 92 publications

References 36 publications

Structural analysis and cytokine-induced activity of gelling sulfated polysaccharide from the cystocarpic plants of Ahnfeltiopsis flabelliformis

Structural analysis and cytokine-induced activity of gelling sulfated polysaccharide from the cystocarpic plants of Ahnfeltiopsis flabelliformis

Chemical and Spectral Characterization of The Ozonation Products of κ-Carrageenan

Kinetics of Oxidative Depolymerization of κ-carrageenan by Ozone

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