Low-molecular-weight heparin calcium attenuates the tourniquet-induced ischemia-reperfusion injury in rats

He, Jinwen; He, Liangzhi; Lü, Fan; Geng, Bin; Xia, Yayi

doi:10.1016/j.injury.2021.03.006

Cited by 2 publications

(4 citation statements)

References 43 publications

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“…Pain degree of the wound: Visual analogue scale 10 was used to assess the degree of pain on admission and after treatment, with a total score of 0–10. The higher the score, the more obvious the pain degree of the affected limb.…”

Section: Methodsmentioning

confidence: 99%

“…[7][8][9] Low molecular weight heparin calcium is a widely used anticoagulant in the clinic, which can effectively prevent venous thrombosis, and the occurrence of venous thrombosis can aggravate scar or hinder scar healing, and low molecular weight heparin calcium can effectively improve the burn with microcirculation of venous thromboembolism, accelerate local blood supply, so as to improve scar hyperplasia. 8,10 At present, there are few clinical reports about hydrocolloid dressing combined with low molecular weight heparin calcium in burn patients with venous thromboembolism. This study observed that hydrocolloid dressing combined with low molecular weight heparin calcium can effectively improve the scar hyperplasia degree of burn patients with venous thromboembolism, and the curative effect is remarkable.…”

Section: Introductionmentioning

confidence: 99%

“…It is widely used in chronic wounds such as pressure ulcers and venous ulcers, as well as acute wounds such as surgical wounds, superficial wounds and skin donation wounds 7‐9 . Low molecular weight heparin calcium is a widely used anticoagulant in the clinic, which can effectively prevent venous thrombosis, and the occurrence of venous thrombosis can aggravate scar or hinder scar healing, and low molecular weight heparin calcium can effectively improve the burn with microcirculation of venous thromboembolism, accelerate local blood supply, so as to improve scar hyperplasia 8,10 . At present, there are few clinical reports about hydrocolloid dressing combined with low molecular weight heparin calcium in burn patients with venous thromboembolism.…”

Section: Introductionmentioning

confidence: 99%

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Effect of hydrocolloid dressing combined with low molecular weight heparin and calcium on scar hyperplasia in burn patients with venous thromboembolism

Wang

Fan

et al. 2023

International Wound Journal

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The purpose of this study is to investigate the effect of hydrocolloid dressing combined with low molecular weight heparin calcium on scar hyperplasia in burn patients with venous thromboembolism. A retrospective analysis was made on 98 patients with burns complicated with venous thromboembolism in Renmin Hospital, Hubei University of Medicine from January 2020 to April 2021. According to different treatment methods, they were divided into a control group (48 cases) and a research group (50 cases), who were given low molecular weight heparin calcium combined with routine treatment and hydrocolloid dressing on the basis of the control group. The wound healing time, dressing change times and infection symptom regression time in the study group were significantly lower than those in the control group (P < .05). After the intervention, the degree of wound pain in both groups was reduced, and the degree of wound pain in the study group was significantly lower than that in the control group, with statistical significance (P < .05). Fibrinogen, activated partial thromboplastin (APPT), D‐dimer, fibrinolytic degradation products, prothrombin time and activated partial prothrombin time of the two groups were all improved. The degree of scar hyperplasia in both groups was improved, and the degree of scar hyperplasia in the study group was significantly better than that in the control group, and the difference was statistically significant (P>.05). Complications in the study group were lower than those in the control group, and the difference was statistically significant (P < .05). The hydrocolloid dressing combined with low molecular weight heparin calcium can effectively shorten the wound healing time and infection symptom regression time of burn patients with venous thromboembolism, reduce the number of dressing changes, reduce the degree of pain, have no influence on coagulation function, reduce the degree of scar, and reduce the incidence of complications.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of hydrocolloid dressing combined with low molecular weight heparin and calcium on scar hyperplasia in burn patients with venous thromboembolism

Wang

Fan

et al. 2023

International Wound Journal

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“…In order to evaluate the presence of tissue edema, the wet-to-dry ratio was calculated utilizing the following formula: wet/dry ratio = (wet weight/dry weight) × 100%. 4,28…”

mentioning

confidence: 99%

Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis

Cui,

Liu,

Zhang

et al. 2024

DDDT

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Low-molecular-weight heparin calcium attenuates the tourniquet-induced ischemia-reperfusion injury in rats

Cited by 2 publications

References 43 publications

Effect of hydrocolloid dressing combined with low molecular weight heparin and calcium on scar hyperplasia in burn patients with venous thromboembolism

Effect of hydrocolloid dressing combined with low molecular weight heparin and calcium on scar hyperplasia in burn patients with venous thromboembolism

Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis

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