Low prevalence of antibody to human parvovirus B19 in Singapore

Matsunaga, Yasuko; Goh, Kee Tai; Utagawa, Etsuko; Muroi, Norihiro

doi:10.1017/s0950268800068552

Cited by 20 publications

(23 citation statements)

References 11 publications

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“…A similar situation was found in Denmark: 37% of children in the 1-to 5-year-old group were seropositive, while 87% in the group of C50-year-old adults had protective antibodies [26]. In a Singapore study, protective antibodies were found in only 16.2% of the serum samples [27].…”

Section: Discussionsupporting

confidence: 67%

Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

2010

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Section: Discussionsupporting

confidence: 67%

Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

2010

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“…In Asian countries the epidemiology of B19 infection is quite distinct. The antibody prevalence is very low in Hong Kong 19 , Singapore 21 and Taiwan 20 , when compared to countries in Occident. Intervals of 10 years between outbreaks have been described in Japan 34 .…”

Section: Discussionmentioning

confidence: 83%

Study of chronic hemolytic anaemia patients in Rio de Janeiro: prevalence of anti-human parvovirus B19 IgG antibodies and the developement aplastic crises

Sant'Anna¹,

Garcia²,

Marzoche³

et al. 2002

Rev. Inst. Med. trop. S. Paulo

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The prevalence of anti-human parvovirus B19 IgG antibodies was determined in sera from 165 chronic hemolytic anemia patients, receiving medical care at Instituto Estadual de Hematologia (IEHE), Rio de Janeiro, during the year of 1994. This sample represents around 10% of the chronic hemolytic anemia patients attending at IEHE. Most of these patients (140) have sickle cell disease. Anti-B19 IgG antibodies were detected in 32.1% of patients. No statistically significant difference (p > 0.05) was seen between IgG antibody prevalence in male (27.8%) and female (35.5%) patients. Anti-B19 IgG antibodies were more frequent in older (37.6%) than younger (28.2%) than 20 years old patients, although this difference had no statistical significance (p > 0.05). Anti-B19 IgG antibody prevalence showed that 67.9% of patients enrolled in the study were susceptible to B19 acute infection. With the aim to detect acute B19 infection, patients follow up continued until February 1996. During this period four patients presented transient aplastic crisis due to human parvovirus B19 as confirmed by the detection of specific IgM antibodies. All four patients were younger than 20 years old, and 3 were younger than 10 years old. Three of them were sickle cell disease patients. Three of the four acute B19 infection occurred during 1994 springtime.

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“…[16] In most of the countries, B19 virus infection occurs during childhood and by the age of 15 years, approximately 50% of children have anti B19 antibody. B19 prevalence may further increase during lifetime and reach values higher than 85% in elderly.…”

Section: Discussionmentioning

confidence: 99%

Standardization of B19 IgG ELISA to study the seroepidemiology of parvovirus B19 in North Indian voluntary blood donors

Kishore

Srivastava

Choudhary

2010

Asian J Transfus Sci

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Backgound and Objectives:Parvovirus B19 (B19) being a non-enveloped DNA virus is hence thermo-stable to the current methods of viral inactivation. Therefore transfusion of blood or its component from a viremic donor to non-immune recipients may result in transfusion-transmitted B19 infection with occasional sinister complications. The serologically naïve blood donor population in our country has not been studied. Hence a study was designed to find the sero-status of B19 virus in normal voluntary blood donor population (relatives of recipients) as an indirect measure of the susceptibility to B19 in north Indians together with seroepidemiology of B19.Methods:An in-house anti-B19 IgG ELISA was standardized using cloned, baculovirus expressed, and purified VP1/VP2 capsid proteins as antigen. Anti-B19 IgG antibodies in sera (diluted 1:400) of 1000 healthy voluntary blood donors (18-60 years; mean 30.5 years) were analyzed and their epidemiologic data were documented.Results:A total of 399 (39.9%) donors were seropositive for B19 virus. Seroprevalence was higher in males than females (44% vs 27%) and it increased with increasing age (P<0.01). Socioeconomically, B19 IgG antibody positivities were 61.8%, 61.1%, and 44.4% in low, medium, and high income groups respectively with unskilled laborers having higher seroprevalence in low (48.5%) and middle (58.7%) income group (P<0.05). Housing conditions revealed B19 seroprevalence as 42.6% in donors living in small houses compared to 20.4% in larger houses (P<0.01) but no difference with religion.Conclusions:Seroprevalence to B19 in normal voluntary blood donors was low leaving a large proportion of north Indians susceptible to B19 infection.

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Low prevalence of antibody to human parvovirus B19 in Singapore

Cited by 20 publications

References 11 publications

Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

Study of chronic hemolytic anaemia patients in Rio de Janeiro: prevalence of anti-human parvovirus B19 IgG antibodies and the developement aplastic crises

Standardization of B19 IgG ELISA to study the seroepidemiology of parvovirus B19 in North Indian voluntary blood donors

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