Low prevalence of Clostridium septicum fecal carriage in an adult population

Kopliku, Fatos; Schubert, Alyxandria M.; Mogle, Jill A.; Schloss, Patrick D.; Young, Vincent B.; Aronoff, David M.

doi:10.1016/j.anaerobe.2014.12.001

Cited by 15 publications

(5 citation statements)

References 19 publications

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“…In decades past, C. septicum was thought to colonize the distal ileum and proximal colon, but subsequent studies have shown colonization to be rare and transient. 3,[31][32][33][34] Virulence is attributed to the production of several exotoxins and motility; the αtoxin in particular has been associated with severe pathogenicity [1,2, 30,35,]. The ability of α-toxin-producing strains to inhibit neutrophil function has been well described.…”

Section: Discussionmentioning

confidence: 99%

Nontraumatic Clostridium septicum Myonecrosis in Adults

Forrester¹,

Shkolyar²,

Gregg³

et al. 2016

Infect Dis Clin Pract

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Clostridium septicum is a spore-forming anaerobic gram-positive rod capable of causing rapidly progressive nontraumatic myonecrosis. A case of nontraumatic C. septicum myonecrosis (ntCSM) is described. A systematic review of all published cases of ntCSM from 2000-2015 was performed. Twenty-three cases of ntCSM were identified. The median age was 67 years (range, 26-84 years) and 15 (68%) were men. Only 5 (21%) patients had multifocal disease. Diabetes mellitus was the most common preexisting medical condition present in 9 (39%) patients. Occult colon cancer was frequently associated with ntCSM and most commonly right-sided colon cancer (69%). Only 10 (42%) patients survived. Clostridium septicum myonecrosis is a surgical emergency associated with morbidity and mortality. Rapid and aggressive debridement remains the cornerstone of care, although mortality has changed little in the last 30 years, suggesting an opportunity for improving diagnosis, treatment, or both.

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Section: Discussionmentioning

confidence: 99%

Nontraumatic Clostridium septicum Myonecrosis in Adults

Forrester¹,

Shkolyar²,

Gregg³

et al. 2016

Infect Dis Clin Pract

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“…Clostridium species are anaerobic, large, gram-positive, gas-producing rod-like bacteria with the ability to produce environmentally resistant endospores that are widespread in nature and can be found in soil and the intestinal tracts of humans and animals [2]. Still, C. septicum is considered a rare component of the gastrointestinal flora, only present in 2% of the population, preferably localized in the cecum and ileocecal junction [3]. Its capacity to cause disease likely originates from coincidental occurrence of transient carriage and enhanced host susceptibility [4].…”

Section: Pathogenesis and Diagnosismentioning

confidence: 99%

“…2 Department of Emergency Medicine, ASZ Aalst, Aalst, Belgium. 3 Department of Vascular Surgery, ASZ Aalst, Aalst, Belgium. 4 Department of Radiology, ASZ Aalst, Aalst, Belgium.…”

Section: Abbreviationsmentioning

confidence: 99%

Clostridium myonecrosis — a rare and underdiagnosed condition in the elderly: a case with severe skipping lesions and an overview of treatment guidelines

et al. 2022

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We present an unusual and severe case of spontaneous clostridial myonecrosis (SCM) in an elderly patient, with severe skipping lesions spread throughout the body. CT imaging, combined with postmortem available blood cultures, confirmed the diagnosis. We noted an underrepresentation of SCM in the cohort of elderly patients (≥ 85 years), upon a review of case reports in the literature over the last decade. Given the worldwide demographic change resulting in an increase in the number of visits to emergency departments for this age group, it is likely that SCM is underdiagnosed in these elderly patients. This case report aims to increase awareness among emergency physicians to recognize the disease as well as to provide a treatment guideline, in order to provide better care and outcome.

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“…, 2 Reports indicate that this microorganism can cause tissue necrosis, hemolysis, intravascular thrombosis, and disseminated intravascular coagulation 3 4 although it has not been identified in studies of human fecal cultures 5 …”

Section: To the Editormentioning

confidence: 99%