Low temperature plasma equipment applied on surgical hemostasis and wound healings

Abstract

Low temperature plasma (LTP) coagulation equipment, which avoids causing burn injuries to patients, has been introducing into minimally invasive surgery. The mechanism by which this equipment stops bleeding is to directly occupy the injury with the formed blood clots, and different from the mechanism of the common electrical hemostatic devices that cauterize the tissues around the bleeding to stem the blood flow. A noteworthy point is that LTP treatment with our equipment is not confined only to the blood coagulation system, but it has significant effects on the other blood components to form clots with or without hemolysis, and that there is a plasma current threshold that determines whether the treatment makes stable clots. In this review, we introduce the clinical benefits of LTP current and describe the clot formation it facilitates.

High throughput image cytometry micronucleus assay to investigate the presence or absence of mutagenic effects of cold physical plasma

“…Great efforts are currently made extending the range of plasma applications with different devices. This includes blood coagulation [Amritkar et al, 2013;Aleinik et al, 2017;Miyamoto et al, 2017], ophthalmology [Rosani et al, 2015;Ye et al, 2015;Recek et al, 2016], oncology [Ye et al, 2015;Mirpour et al, 2016;Binenbaum et al, 2017], and various diseases in dermatology [Daeschlein et al, 2010[Daeschlein et al, , 2011Klebes et al, 2014]. Addressing not only the efficacy but also safety of different plasma sources or their optimum operational settings, genotoxic testing is indispensable.…”

Formation of reactive oxygen species by irradiation of cold atmospheric pressure plasma jet to water depends on the irradiation distance

“…(1) CAP can be applied to biological samples because it is produced at room temperature and normal atmospheric pressure. (2) Therefore, CAP has potential for biomedical applications such as wound healing, (3)(4)(5)(6) infection control, (7)(8)(9)(10) and cancer therapy. (11)(12)(13)(14) There are at least three types of CAP used for biological samples: 1) plasma jets, 2) corona discharge plasma sources, and 3) dielectric barrier discharge plasma sources.…”

Utilization of low-temperature helium plasma (J-Plasma) for dissection and hemostasis during carotid endarterectomy

“…18 This mechanism is similar to the mechanism of surgical hemostats that stimulate aggregation of platelets and coagulation factors. 19 In a study by Pedroso et al, 20 this specific device was applied on porcine liver, kidney, and muscle tissue at different power levels and gas flows. It was shown that J-Plasma has minimal lateral and depth spread when it is applied to various tissue types, even at higher power settings or gas flow rates.…”