Low temperature purification method for the determination of abamectin and ivermectin in edible oils by liquid chromatography–tandem mass spectrometry

Huang, Jianxiang; Lu, Dahai; Wan, Kai; Wang, Fuhua

doi:10.1016/j.cclet.2014.01.036

Cited by 27 publications

(12 citation statements)

References 29 publications

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“…40 The maximum residue limit (MRL) of ABA in oil, oilseeds, and other foods is 10.0-50.0 μg/kg in various countries. [40][41][42] In this work, the viscous peanut oil spiked with ABA (1.0 μg/mg) was loaded onto the WT for Table 2, these results indicated that this method is a rapid (analytical time~12 minutes) and has comparable sensitive technique for detecting abamectin in edible oils. It is also noted that the reproducibility (RSD: 16.1%) in this work is greater than previous work, [40][41][42] because the signal obtained by functionalized TESI could be influenced by many more factors, such as efficiency of extraction, cleanup, elution, and spray ionization of analytes on the tip.…”

Section: Enhanced Detection Of Target Analytes From Complex Samplesmentioning

confidence: 64%

“…Compared with other methods in which the detections of ABA are mainly based on sample extraction and LC separation, which showed excellent sensitivity (LOD ≤ 1.0 μg/kg, LOD ≤ 3.0 μg/kg), acceptable reproductivity (RSD ≤ 10%), and time‐consuming process (analytical time ≥ 1 hour), as listed in Table , these results indicated that this method is a rapid (analytical time ~12 minutes) and has comparable sensitive technique for detecting abamectin in edible oils. It is also noted that the reproducibility (RSD: 16.1%) in this work is greater than previous work, because the signal obtained by functionalized TESI could be influenced by many more factors, such as efficiency of extraction, cleanup, elution, and spray ionization of analytes on the tip . This study demonstrated that functionalized TESI‐MS could be applied as a rapid method for selective enrichment of target analytes in complex samples based on the analyte‐substrate interaction in sampling.…”

Section: Resultsmentioning

confidence: 84%

“…However, high amounts of abamectin b1a (ABA), a commonly used pesticide, are widely used in peanut crops to control pests . The maximum residue limit (MRL) of ABA in oil, oilseeds, and other foods is 10.0–50.0 μ g/kg in various countries . In this work, the viscous peanut oil spiked with ABA (1.0 μ g/mg) was loaded onto the WT for direct analysis; the main components of the oil sample, triacylglycerides (TAGs) such as [TAG(C54:1) + Na] + , were overwhelmingly detected in the spectrum (Figure S9A).…”

Section: Resultsmentioning

confidence: 99%

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Analyte‐substrate interactions at functionalized tip electrospray ionization mass spectrometry: Molecular mechanisms and applications

Yao

2018

J Mass Spectrom

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Conventional electrospray ionization mass spectrometry (ESI‐MS) commonly uses capillary tip for sample introduction and ionization. In recent years, ESI‐MS using noncapillary substrate tips has attracted growing interest as it allows separation and enrichment of analytes from complex samples due to analytes‐substrate interactions. In this work, model mixtures and functionalized tips were employed to investigate the molecular mechanism of the analyte‐substrate interactions. The mixtures were directly loaded on substrate tips, and then temporal responses of analytes were investigated by monitoring selected ion chromatogram (SIC) responses of each analyte. It is found that all analytes are sprayed out together when bulk solution loaded substrate surface and then sequential ionization of analytes were observed. Sequential ionization of analytes was affected by the analytes‐substrate interactions which caused analytes of weaker‐interaction to be faster moved and the analytes of stronger‐interactions to be retained on the substrate. The main molecular mechanisms of analyte‐substrate interactions were revealed to be hydrophobic interactions and electrostatic interactions. Furthermore, based on the mechanistic insights, functionalized tips were further applied for rapid extractive sampling of target analytes from complex samples with good analytical performances. Overall, this study on the mechanism and applications of analyte‐substrate interactions is useful for understanding the fundamental principles and further developments of functionalized tip electrospray ionization (TESI).

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Section: Enhanced Detection Of Target Analytes From Complex Samplesmentioning

confidence: 64%

Section: Resultsmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 99%

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Analyte‐substrate interactions at functionalized tip electrospray ionization mass spectrometry: Molecular mechanisms and applications

Yao

2018

J Mass Spectrom

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“…The low-temperature purification (LTP) method was introduced by Lentza-Rizos et al (2001) for the analysis of organophosphorous insecticides in olive oil by gas chromatography (GC), and was recently applied for the analysis of pyrethroids in whole milk samples (Goulart et al 2008), besides the determination of residues of veterinary drugs in edible oil (Huang et al 2014), pig muscle (Lopes et al 2011), bovine muscle (Rübensan et al 2013, and milk (Rübensan et al 2011;Jank et al 2015). In the LTP procedure, the extract is obtained adding acetonitrile into the sample, followed by freezing at −20 °C.…”

Section: Introductionmentioning

confidence: 99%

Development of high-throughput multi-residue method for non-steroidal anti-inflammatory drugs monitoring in swine muscle by LC-MS/MS

Castilhos

Barreto

Meneghini

et al. 2016

Food Additives & Contaminants: Part A

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A reliable and simple method for the detection and quantification of residues of 14 non-steroidal anti-inflammatory drugs and a metamizole metabolite in swine muscle was developed using liquid chromatography-electrospray ionisation-tandem mass spectrometry (LC-ESI-MS/MS). The samples were extracted with acetonitrile (ACN) in solid-liquid extraction followed by a low-temperature partitioning (LLE-LTP) process at -20 ± 2°C. After evaporation to dryness, the residue was reconstituted with hexane and a mixture of water:acetonitrile (1:1). LC separation was achieved on a reversed-phase (RP18) column with gradient elution using water (phase A) and ACN (phase B) both containing 1 mmol l(-)(1) ammonium acetate (NH4COO) with 0.025% acetic acid. Analysis was carried out on a triple-quadrupole tandem mass spectrometer (LC-MS/MS) in multiple reaction monitoring mode using an electrospray interface in negative and positive mode in a single run. Method validation was performed according to the criteria of Commission Decision No. 2002/657/EC. The matrix effect and linearity were evaluated. Decision limit (CCα), detection capability (CCβ), accuracy and repeatability of the method are also reported. The proposed method proved to be simple, easy and adequate for high-throughput analysis and was applied to routine analysis by the Brazilian Ministry of Agriculture, Livestock and Food Supply.

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“…Analytical method of analysis by high performance liquid chromatography (HPLC). The residues of avermectins in biological matrices are usually determined using solid phase extraction and liquid chromatography with a fluorescence detector (He et al, 2005;Kaufmann et al, 2014;Danaher et al, 2006;Giannetti et al, 2011;de Souza Santos Cheibub et al, 2019), as well as liquid chromatography combined with tandem mass spectrometry (Huang et al, 2014;Ortiz et al, 2017;Manjusha R. Jadhav et al, 2019;Yashpal et al, 2018;Sheridan and Desjardins, 2006). The ultra-high-performance liquid chromatography tandem mass spectrometry method (UHPLC-MS/MS) is a confirmatory method for detecting the level of avermectins in animal tissues and milk.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Ultra-High-Performance Liquid Chromatography (HPLC) Tandem Mass Spectrometry for Determination of Avermectin Residues in Milk

Bayer¹,

Kaminska²,

Bondarets³

et al. 2019

Ukr J Ecol

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The study was conducted to evaluate the applicability of ultra high-performance liquid chromatography - tandem mass spectrometry method (UHPLC-MS/MS), establish the MS/MS detection parameters and determine the validation characteristics for the analysis of residual content of avermectins in milk. The UHPLC-MS/MS method has proved to be accurate, practical and universal. This was confirmed by Decision limit (CCα) data: abamectin - 12.56 μg/kg, doramectin - 17.74 μg/kg, eprinomectin - 24.02 μg/kg, ivermectin - 12.53 μg/kg, moxidectin - 44.69 μg/kg, recovery is 88.7-110%. The data obtained for assessing the suitability, accuracy and reproducibility of the results meet the requirements of the European Directive (2002/657/EC). The efficient ultra high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method that was developed and adopted for routine use by the laboratories of veterinary medicine, allows to detect residual quantities of 5 avermectins used in animal breeding for the prevention of helminthiases in food products including milk.

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Low temperature purification method for the determination of abamectin and ivermectin in edible oils by liquid chromatography–tandem mass spectrometry

Cited by 27 publications

References 29 publications

Analyte‐substrate interactions at functionalized tip electrospray ionization mass spectrometry: Molecular mechanisms and applications

Analyte‐substrate interactions at functionalized tip electrospray ionization mass spectrometry: Molecular mechanisms and applications

Development of high-throughput multi-residue method for non-steroidal anti-inflammatory drugs monitoring in swine muscle by LC-MS/MS

Evaluation of Ultra-High-Performance Liquid Chromatography (HPLC) Tandem Mass Spectrometry for Determination of Avermectin Residues in Milk

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