This study proposes a high-resilience foam-core composite with bionic micro-interface lattice structure using columnar lattice mold and two-step foaming technique. This foam-core composite uses polyamides nonwoven fabrics as the bionic surface layers and polyurethane foam as the bionic core layer. The foam cavity diameter and columnar interface area are adjusted by the polyols content and the column diameter, respectively. Effects of the cavity diameter and the column diameter on the compression resistance, static-bursting strength, low-velocity impact, and dynamic cushion efficacy of foam-core composites are investigated. The results show that compression resistance, bursting strength, and cushion efficacy of the foam-core composites are all increased by degrees with the cavity diameter when the content of polyols increases.When the cavity diameter was 195 μm, bionic micro-interface foam-core composite absorbed 99% low-velocity impact energy. Existence of bionic micro-interface lattice obviously improved the static compression and bursting properties. Bionic microinterface foam-core composites with 16 mm-diameter column have the lower and wider contact force peak compared to pomelo, 8 mm and 12 mm-diameter column, indicating higher dynamic cushion efficacy. The resulted composite provides an idea of establishing bionic foam-core cushion composites by foam interface, which is expected to be used as energy absorption material for commercial application.