Lower Extremity Cellulitis and Bacteremia With Herbaspirillum seropedicae Associated With Aquatic Exposure in a Patient With Cirrhosis

Tan, Michael J.; Oehler, Richard L.

doi:10.1097/01.idc.0000170026.41994.8d

Cited by 20 publications

(29 citation statements)

References 8 publications

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“…Herbaspirillum spp. have been recovered from the blood of patients with cystic fibrosis (22), leukemia (23,24), and cellulitis and bacteremia (25) and from sputum (22). They have been also found in arterial walls of aortic aneurysms (26).…”

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confidence: 96%

“…They have been also found in arterial walls of aortic aneurysms (26). The isolates were identified as Herbaspirillum by 16S rRNA gene sequencing, and at least three species were identified: H. seropedicae, Herbaspirillum huttiense, and Herbaspirillum frisingense (22,25); additionally among these, two subspecies (Herbaspirillum huttiense subsp. huttiense and Herbaspirillum huttiense subsp.…”

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confidence: 99%

“…putei) and three distinct lineages were characterized (22,27). All these isolates have been misidentified as Ralstonia, Burkholderia cepacia complex, Cupriavidus pauculus, or Ochrobactrum anthropi (22,24) or could not be identified (22,23,25) by phenotypic identification methods used in the clinical laboratory.…”

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confidence: 99%

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Biochemical Characteristics, Adhesion, and Cytotoxicity of Environmental and Clinical Isolates of Herbaspirillum spp

et al. 2015

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e Herbaspirillum bacteria are best known as plant growth-promoting rhizobacteria but have also been recovered from clinical samples. Here, biochemical tests, matrix-assisted laser deionization-time of flight (MALDI-TOF) mass spectrometry, adherence, and cytotoxicity to eukaryotic cells were used to compare clinical and environmental isolates of Herbaspirillum spp. Discrete biochemical differences were observed between human and environmental strains. All strains adhered to HeLa cells at low densities, and cytotoxic effects were discrete, supporting the view that Herbaspirillum bacteria are opportunists with low virulence potential.

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Biochemical Characteristics, Adhesion, and Cytotoxicity of Environmental and Clinical Isolates of Herbaspirillum spp

et al. 2015

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“…Its close phylogenetic and phenotypic resemblance to Burkholderia cepacia complex has often resulted in misidentification (2,4). Although one of the earliest documented human infections with this organism was reported in 2005 from a wound isolate in a 49-year-old homeless man with a history of chronic liver disease (8), the advent of new technology has led to the reclassification as Herbaspirillum of previously identified and other, unclassified human isolates obtained as early as 1978 from infections of the ear, eye, knee, urine, oropharnyx, gastrointestinal tract, blood, and respiratory tract (2). Between 2000 and 2007, the Burkholderia cepacia Research Laboratory and Repository at the University of Michigan, Ann Arbor, isolated Herbaspirillum from 28 sputum cultures and one blood isolate referred from 23 cystic fibrosis (CF) treatment centers in the United States; 19 (68%) of the isolates had been initially identified as Burkholderia (4).…”

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Herbaspirillum Species Bacteremia in a Pediatric Oncology Patient

Ziga

Druley²,

Burnham

2010

J Clin Microbiol

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Herbaspirillum species, an organism commonly found in soil, has only recently been linked to disease in humans. We report Herbaspirillum bacteremia in a 2-year-old female patient following a hematopoietic stem cell transplant for relapsed acute lymphoblastic leukemia. CASE REPORTWe report the case of a 2-year-old female diagnosed with acute lymphoblastic leukemia (ALL) classified as high-risk due to MLL gene rearrangement. A double-lumen Broviac catheter was placed for intravascular access. The child went into clinical remission after standard five-drug induction chemotherapy, but cytogenetic analysis of her bone marrow following induction revealed the presence of persistent leukemic cells, conferring a risk for relapse. As a result, she underwent a matched, unrelated donor hematopoietic stem cell transplant (MUD HSCT). The child's course of treatment was uncomplicated until posttransplant day 162, when she was admitted with a 2-day history of fever (maximum temperature, 103.5°F) and diarrhea. She presented to her local hospital emergency room, where she was found to be tachycardic and febrile. She received two intravenous normal saline fluid boluses and was empirically started on ceftriaxone (50 mg/kg of body weight) prior to transfer to our hospital.On admission, the patient was hemodynamically stable, with an unremarkable physical examination. Admission laboratory results included a white blood cell (WBC) count of 3,400/mm 3 , with 83% neutrophils, 1% bands, 11% lymphocytes, 5% monocytes, an absolute neutrophil count of 2,822, and a hemoglobin level of 9.5 g/dl. She was empirically started on cefepime (50 mg/kg) administered every 8 h. Given the history of diarrhea, stool was sent for enteric culture and Clostridium difficile toxin testing. These studies were negative, and the child's diarrhea resolved spontaneously on admission.Isolator blood cultures were drawn on admission from both the red and the white central venous line lumens, and within 36 h, the quantity (CFU/ml) of a long, thin, oxidasepositive, weakly catalase-positive, Gram-negative bacillus was too numerous to count. At this point, gentamicin (2.5 mg/kg/dose every 8 h) was added to the antibiotic therapy.Two days later, an Isolator blood culture from the white lumen was still growing the same organism in a quantity too numerous to count, while 39 CFU/ml was recovered from the red lumen. Blood cultures drawn on the third day from both central venous line lumens and a peripheral site were sterile. Antibiotic therapy was changed to meropenem at a dose of 20 mg/kg every 8 h for a total of 7 days following the negative blood culture.The Vitek 2 Gram-negative identification system identified the organism as Burkholderia cepacia complex. The corresponding Kirby-Bauer disk diffusion susceptibility testing showed that the isolate was colistin resistant (consistent with B. cepacia) but susceptible to piperacillin-tazobactam, ticarcillinclavulanic acid, trimethoprim-sulfamethoxazole, meropenem, ceftazidime, gentamicin, amikacin, tobramycin, ciprofloxacin, ...

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“…These species are not known to be human pathogens. Only a single case of human infection due to Herbaspirillum has been described in detail (13). This involved bacteremia and cellulitis due to H. seropedicae in a 49-year-old homeless man with cirrhosis.…”

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Recovery of Herbaspirillum Species from Persons with Cystic Fibrosis

et al. 2008

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Herbaspirillum species are not known to be human pathogens. We report on the identification of Herbaspirillum from cultures from 28 persons with cystic fibrosis (CF). Most isolates were initially identified as members of the Burkholderia cepacia complex. Although the role that these species play in lung disease in persons with CF is not known, their differentiation from other species is important and has serious implications for clinical care and patient well-being.

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Lower Extremity Cellulitis and Bacteremia With Herbaspirillum seropedicae Associated With Aquatic Exposure in a Patient With Cirrhosis

Cited by 20 publications

References 8 publications

Biochemical Characteristics, Adhesion, and Cytotoxicity of Environmental and Clinical Isolates of Herbaspirillum spp

Biochemical Characteristics, Adhesion, and Cytotoxicity of Environmental and Clinical Isolates of Herbaspirillum spp

Herbaspirillum Species Bacteremia in a Pediatric Oncology Patient

Recovery of Herbaspirillum Species from Persons with Cystic Fibrosis

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