Lower Urinary Tract Symptoms and Sexual Dysfunction in Community-Dwelling Men

Chung, Won-Tae; Nehra, Ajay; Jacobson, Debra J.; Roberts, Rosebud O.; Rhodes, Thomas; Girman, Cynthia J.; Lieber, Michael M.; Jacobsen, Steven J.

doi:10.1016/s0025-6196(11)62626-8

Cited by 40 publications

(18 citation statements)

References 29 publications

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“…A score ranging from 0 to 5 was assigned with "5 times" or "6 or more times" corresponding to a score of 5. These scores were summed to create a score ranging from 0 to 35, which we categorized into 4 groups: no or low (0-7), low-moderate (8)(9)(10)(11)(12)(13)(14), high-moderate (15)(16)(17)(18)(19), and severe (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) symptoms.…”

Section: Exposure Assessment (Luts)mentioning

confidence: 99%

“…Both ED and LUTS are associated with decreased quality of life. 3,4 Many studies have found a positive association between LUTS and ED 2,[5][6][7][8][9][10][11][12][13][14][15][16] ; all but one 16 were cross-sectional. Because the cross-sectional design cannot address the temporal relationship between LUTS and ED it remains unclear whether this association is causal.…”

Section: Introductionmentioning

confidence: 99%

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A Prospective Study of Lower Urinary Tract Symptoms and Erectile Dysfunction

et al. 2008

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Purpose-Several studies have reported that men with lower urinary tract symptoms (LUTS) are more likely to experience erectile dysfunction (ED). All but one of these studies was crosssectional, limiting inferences about whether LUTS precipitate ED.Materials and Methods-The association between LUTS and incident ED was examined prospectively in the Health Professionals Follow-up Study. LUTS were assessed biennially by the American Urological Association Symptom Index, which captures symptoms of frequency, urgency and force of urinary stream. Severe LUTS was defined as a symptom score of ≥ 20 points and no LUTS was defined as a score of ≤ 7 points, both among men not treated for LUTS. In 2000, the men were asked to rate their erectile function for several time periods. ED was defined as "poor" or "very poor" function or use of ED medications and no ED was defined as "very good" or "good" function and no use of ED medications. We estimated risk ratios using Poisson regression adjusting for age and other potentially confounding factors.Results-We observed 3,953 incident ED cases among 17,086 men. Men with severe LUTS in 1994 or earlier had a statistically significant 40% higher risk of ED subsequently than men without LUTS. The risk of ED increased with increasing LUTS severity (p trend < 0.0001). The positive association between LUTS and ED was stronger among younger than older men (p interaction = 0.03).Conclusions-This study provides evidence that men with LUTS are more likely to develop ED subsequently.

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Section: Exposure Assessment (Luts)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Prospective Study of Lower Urinary Tract Symptoms and Erectile Dysfunction

et al. 2008

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“…4,[6][7][8][9] The current analysis from the PCAW program provides one of the largest known studies, which adjusted for the apparent effect of other known risk factors on sexual health including age, comorbidities, smoking and testosterone level. Further to our knowledge, it is the first analysis to address the effect of race on the overall sexual health in a large cohort of men in the USA.…”

Section: Correlation Between Luts and Edmentioning

confidence: 99%

Correlation between LUTS (AUA-SS) and erectile dysfunction (SHIM) in an age-matched racially diverse male population: data from the Prostate Cancer Awareness Week (PCAW)

et al. 2005

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The relationship between lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia and sexual health in men participating in a national multicenter screening program was studied. A total of 12 679 men were screened for prostate cancer in the year 2003. Of these, 6641 men had completed both the American Urological Association Symptom Score (AUA-SS) and the Sexual Health Inventory for Men (SHIM) questionnaires. We assessed the apparent effect of comorbidities (ischemic heart disease, hypertension, hypercholesteremia and diabetes), smoking habits and testosterone level on the overall sexual health. Age and race were also assessed as factors affecting the SHIM score. We used a general linear multivariable regression analysis to express the effect of these variables on the sexual health in these men adjusting for the apparent effect of LUTS. The mean and median age of the population was 58.479.8 and 58 y, respectively. The median AUA-SS was 4/25 (mean ¼ 5.775.3) and SHIM score was 19/25 (mean ¼ 16.375.9). Of the men, 4948 (75%) were Caucasian and 1154 (17%) were from African-American racial origin. A high AUA-SS appears to have a negative effect on the overall sexual health (Po0.05) after adjusting for all other confounding factors. As expected, age showed a significant inverse correlation with SHIM score (Po0.05). Caucasian men on average appear to have a significantly higher SHIM score by 6.5 points when compared to African-American men after adjusting for age, comorbidities, smoking habits, and AUA-SS (Po0.05). However, with increasing age, the difference in SHIM score diminishes between the two groups. Further, smoking and comorbidities were strong predictors of poor sexual health performance. Interestingly, hypogonadism (testosterone o300 ng/dl) was not a significant risk factor (P ¼ 0.104) when adjusting for all other variables. Nonetheless, in a univariate analysis, testosterone levels significantly correlated with reported SHIM scores (Po0.05). The overall sexual health in aging men is substantially affected not only by age, but by the severity of their urinary symptoms after adjusting for the most common known risk factors, suggesting perhaps a common underlying pathophysiology. Moreover, race appears to constitute another neglected potential risk factor, which should be investigated further in future studies.

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“…Other less commonly used questionnaire for EjD included the Brief Sexual Function Inventory (BSFI) and the Utvalg for Kliniske Undersogelser (UKU) Side Effect Scale [Chung et al 2004;Ekselius and Von Knorring, 2001].…”

Section: Questionnairesmentioning

confidence: 99%

A systematic review of the correlates and management of nonpremature ejaculatory dysfunction in heterosexual men

Seyam

2013

Therapeutic Advances in Urology

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BackgroundThere is an increasing interest in nonpremature ejaculatory dysfunction (non-PE EjD). The frontier of sexual medicine has shifted slowly from erectile dysfunction (ED) to premature ejaculation (PE) and now to non-PE EjD. Two factors have contributed to this shift. First is the search for new areas of research and of novel treatments and second is the better characterization of ejaculatory disorders. The development of questionnaires that better characterize the type of ejaculatory dysfunction (EjD) has helped to identify the problem with more precision in different populations.Interest in the global sexual practice patterns gave insight into the prevalence of non-PE EjD in different areas of the world. Within the non-PE EjD itself, a shift in focus occurred over the years. Early and related to prostatic surgery and retroperitoneal lymph node dissection (RPLND) retrograde ejaculation was reported. With the development of α-blockers and finasteride, retrograde ejaculation, EjD and/or orgasmic dysfunction were reported as A systematic review of the correlates and management of nonpremature ejaculatory dysfunction in heterosexual men Raouf SeyamAbstract Introduction: A better understanding of ejaculatory disorders has led to an increasing interest in nonpremature ejaculatory dysfunction (non-PE EjD). Current reviews on the subject use a symptom-based classification to describe ejaculatory dysfunction even when it is a single case report. While these reviews provide important information on the disorder, a clearer picture of the prevalence of non-PE EjD in relation to the community and various pathophysiologic states is needed. Objectives: The objective of this study was to provide a systematic review of studies of non-PE EjD excluding single case reports. Methods: A systematic review of Medline for terms including ejaculation, orgasm or hematospermia. Association with terms delay, pain or headache was made. The search was restricted to male gender and articles written in English. Abstracts were reviewed and those mainly concerned with premature ejaculation were excluded. Results: A total of 333 articles on non-PE EjD were identified. The condition was reported in community-based studies. In certain patient populations, non-PE EjD was commonly reported in association with antidepressant and antipsychotic treatments, in patients with chronic prostatitis/chronic pelvic pain syndrome, patients with lower urinary tract symptoms particularly in association with medical or surgical treatment, patients with retroperitoneal surgery and in patients with neurological diseases. Few articles were concerned with treatment options. Conclusion: There is a significant prevalence of non-PE EjD in the community and in association with particular disease states or as a side effect of medical or surgical interventions. There is a need to direct efforts to prevent and treat these conditions. Keywords: anhedonia, aspermia, ejaculation, epidemiology, headache, hemospermia, orgasm, pain, prevalence adverse events. It became clear ...

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Lower Urinary Tract Symptoms and Sexual Dysfunction in Community-Dwelling Men

Cited by 40 publications

References 29 publications

A Prospective Study of Lower Urinary Tract Symptoms and Erectile Dysfunction

A Prospective Study of Lower Urinary Tract Symptoms and Erectile Dysfunction

Correlation between LUTS (AUA-SS) and erectile dysfunction (SHIM) in an age-matched racially diverse male population: data from the Prostate Cancer Awareness Week (PCAW)

A systematic review of the correlates and management of nonpremature ejaculatory dysfunction in heterosexual men

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