Lower urinary tract symptoms in male population of the Russian Federation North-Western Region: analysis of population study results

Korneyev, Igor A.; Алексеевич, Корнеев Игорь; Alexeeva, Tatyana A.; Анатольевна, Алексеева Татьяна; Al-Shukri, Salman Hasunovich; Хасунович, Аль-Шукри Сальман; Pushkar, D Yu; Юрьевич, Пушкарь Дмитрий

doi:10.17816/uroved615-9

Cited by 7 publications

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“…Урологические ведомости Том 12, № 3, 2022 АКТУАЛЬНОСТЬ Доброкачественная гиперплазия предстательной железы (ДГПЖ) -одно из наиболее частых заболеваний мужчин старшей возрастной группы и основная причина развития у них симптомов нижних мочевыводящих путей (СНМП). В возрасте старше 60 лет клинические проявления ДГПЖ развиваются у более половины мужчин [1,2]. Значимость ДГПЖ обусловлена не только ее высокой распространенностью, но и существенным снижением качества жизни и высоким риском развития осложнений [3,4].…”

Section: оригинальные статьиunclassified

Thulium laser enucleation of prostate (ThuLEP): efficacy and safety evaluation in patients with a prostate volume more than 80 cm3

Kostenkov

Аль-Шукри

Amdiy

et al. 2022

Urology reports (St. - Petersburg)

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BACKGROUND: Benign prostatic hyperplasia is a common condition in men over 60 years of age. The gold standard for the treatment of benign prostatic hyperplasia up to 80 cm3 is transurethral resection of the prostate. At the same time, with a prostate volume of more than 80 cm3, the choice of the optimal method of surgical treatment of benign prostatic hyperplasia is a matter of debate. AIM: Evaluation of the efficacy and safety of thulium laser enucleation of the prostate (ThuLEP) in patients with benign prostatic hyperplasia with a prostate volume of more than 80 cm3. MATERIALS AND METHODS: The study involved 75 patients with benign prostatic hyperplasia aged 64 to 83 years (mean age 70.4 years) with a prostate volume of 80 to 215 cm3 (mean 123.9 cm3). All patients underwent ThuLEP using a thulium fiber laser FiberLase U1 with a power of 120 W. Control examinations were performed 3 and 6 months after the surgery. RESULTS: The duration of surgery averaged 84.7 minutes and ranged from 57 to 135 minutes. The duration of the urethral catheter after surgery averaged 2.8 days. The frequency of intra- and postoperative complications was low, none of the patients required blood transfusion, as well as repeated surgery to coagulate the vessels of the prostate bed. In 3 (4%) patients, superficial damage to the bladder wall occurred during marcellation, which required coagulation of the injury site. All recorded complications belonged to groups I and II according to the Clavien Dindo scale. Examinations carried out after 3 and 6 months showed a significant decrease in the severity of voiding disorders, an increase in the quality of life and an improvement in the outflow of urine from the bladder compared with the baseline. CONCLUSIONS: The results of the study showed high clinical efficacy and safety of the use of thulium laser enucleation of benign prostatic hyperplasia in patients with prostates more than 80 cm3.

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Section: оригинальные статьиunclassified

Thulium laser enucleation of prostate (ThuLEP): efficacy and safety evaluation in patients with a prostate volume more than 80 cm3

Kostenkov

Аль-Шукри

Amdiy

et al. 2022

Urology reports (St. - Petersburg)

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“…Корнеевым и соавт., в России СНМП фиксируются среди мужчин любого возраста, они снижают качество жизни, тесно связаны с сопутствующими метаболическимим нарушениями и эректильной дисфункцией. Авторы делают вывод о том, что мужчинам с расстройствами мочеиспускания показано ком-плексное обследование и лечение с учетом междисциплинарных аспектов проблемы [12].…”

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Opportunities to increase early diagnostics and treatment compliance of BPH progression.

Evdokimov¹,

Spivak²

2022

ECU

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Introduction. Benign prostatic hyperplasia (BPH) is one of the most common diseases of the genitourinary system in men. Severe symptoms of lower urinary tract dysfunction (LUTS), which develop with BPH, worsen the quality of life. Prophylactic examinations, dynamic monitoring and necessary treatment: conservative (nonpharmacological and pharmacological treatment) or surgical treatment are necessary to control the course of the disease. Bioregulatory peptides can be used for early control of LUTS. The aim of the work was to assess the efficacy of early diagnosis and adherence to drug prophylaxis of BPH development and progression using different methods including bioregulatory peptides. Materials and methods. Data of the clinical examination and periodic medical examinations of 1675 men who were enrolled in the program «Complex of measures to increase the efficiency of early diagnostics of BPH and increase adherence to medical prophylaxis of BPH development and progression» were analyzed. After full clinical examination, depending on indications, patients were recommended surgical or conservative treatment – non-medication (behavioral) or medication (α1-adrenoblockers + muscarinic receptor antagonists, 5α-reductase inhibitors or Vitaprost preparations). The patients were observed for 4 years. Efficacy and safety of the use of bioregulatory peptides (Vitaprost®) in patients with BPH and LUTS were compared with the results of treatment in patients who chose behavioral therapy (active observation). Results. Behavioral therapy was used in 221 patients with mild to moderate symptoms, 312 patients were prescribed Vitaprost® Forte and Vitaprost® tablets. Active observation was more often chosen by patients of the youngest group (40-44 years). During Vitaprost® application there were improved IPSS questionnaire indexes, maximal urination rate increased, residual urine volume and prostate volume decreased. Worsening and increase of severity of complaints, according to IPSS questionnaire, decrease of maximum urinary flow rate and increase of residual urine volume and prostate volume were registered in actively observed group of patients. Conclusions. Timely initiation of therapy with Vitaprost® Forte and Vitaprost® tablets in patients with BPH has a favorable efficacy and safety profile. Further analysis of the data received as a result of the regional program is supposed to be carried out to evaluate its results.

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Morphological reconstruction of the bladder in the process of age-related involution

2022

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Objective - study of morphological rearrangements of the bladder and its vascular system in elderly and senile people.Material and methods. Autopsy material in the form of pieces of the bladder wall from 25 men aged 60-80 years was studied using a number of histological, morphometric and statistical techniques. As a control, we used material from 10 persons aged 20-30 years who died as a result of injuries.Results. It was shown that in men in the process of aging in the extraorganic arteries, atherosclerotic changes are revealed, leading to a narrowing of the lumen. In the intraorgan arteries, thickening of the media, hyperelastosis and hyalinosis are observed, which also lead to a reduction in blood flow and are markers of arterial hypertension. A reflection of the adaptation to hemodynamic disorders is the formation of the so-called "closing arteries" with a powerful intimate layer. Over time, in the media of the arteries, as well as in the intima of the "closing vessels", sclerosis grows. The veins of the bladder lose a powerful smooth muscle layer in the wall, undergo sclerosis, which leads to difficulty in blood outflow, aggravating chronic hypoxia. Remodeling of the vascular bed of the bladder leads to detrusor atrophy and degenerative-dysregenerative changes in the urothelium.Conclusion. In the vascular bed of the urinary bladder in elderly and senile men, atherosclerotic and angiotonic changes characteristic of arterial hypertension progress, followed by the development of detrusor atrophy and impaired urothelium regeneration.

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Lower urinary tract symptoms in male population of the Russian Federation North-Western Region: analysis of population study results

Cited by 7 publications

References 7 publications

Thulium laser enucleation of prostate (ThuLEP): efficacy and safety evaluation in patients with a prostate volume more than 80 cm3

Thulium laser enucleation of prostate (ThuLEP): efficacy and safety evaluation in patients with a prostate volume more than 80 cm3

Opportunities to increase early diagnostics and treatment compliance of BPH progression.

Morphological reconstruction of the bladder in the process of age-related involution

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