LOX Index, a Novel Predictive Biochemical Marker for Coronary Heart Disease and Stroke

Inoue, N.; Okamura, Tomonori; Kokubo, Yoshihiro; Fujita, Yoshiko; Sato, Yuko; Nakanishi, Mamoru; Yanagida, Kazuki; Kakino, Akemi; Iwamoto, Seiichi; Watanabe, Makoto; Ogura, Sayoko; Otsui, Kazunori; Matsuda, Haruo; Uchida, Kagehiro; Yoshimoto, Ryo; Sawamura, Tatsuya

doi:10.1373/clinchem.2009.140707

Cited by 105 publications

(108 citation statements)

References 38 publications

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“…The daily consumption of tobacco was 26±13 pieces, and the duration of smoking was 38±12 years. The mean serum sLOX-1 level in the smokers was 1.51±1.04 ng/mL, which is higher than the 0.92 ng/ mL reported in the general population in a population-based Suita cohort study 12) .…”

Section: Discussioncontrasting

confidence: 64%

“…The sLOX-1 level has also been shown to increase in patients with coronary artery diseases in accordance with increases in inflammatory markers 7) . A cohort Suita study of a Japanese population reported that the smoking rate was higher in the group with higher serum sLOX-1 levels than in the group with lower sLOX-1 levels 12) . However, the relationships between the sLOX-1 level and various parameters in smokers are unknown.…”

Section: Correlations Between the Serum Slox-1 Levels And Clinical Pamentioning

confidence: 95%

“…The concentration of sLOX-1 in the serum was measured using an ELISA, as previously described 12) . Briefly, anti-human LOX-1 antibodies (TS92) were immobilized on 384-well plates.…”

Section: Measurement Of Slox-1mentioning

confidence: 99%

“…The serum soluble LOX-1 (sLOX-1) levels have been reported to increase in patients with acute coronary syndrome 9) , type 2 diabetes 10) and obesity 11) . A Japanese cohort study indicated the prevalence of smoking to be higher among people with higher sLOX-1 levels 12) . As LOX-1 has been implicated in inflammatory diseases [13][14][15] , it is conceivable that this molecule is also involved in smoking-induced vascular inflammation.…”

Section: Clinical Characteristics Of the Current Smokersmentioning

confidence: 99%

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Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Plays an Important Role in Vascular Inflammation in Current Smokers

Takanabe-Mori

Ono

Wada

et al. 2013

JAT

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Section: Discussioncontrasting

confidence: 64%

Section: Correlations Between the Serum Slox-1 Levels And Clinical Pamentioning

confidence: 95%

“…The concentration of sLOX-1 in the serum was measured using an ELISA, as previously described 12) . Briefly, anti-human LOX-1 antibodies (TS92) were immobilized on 384-well plates.…”

Section: Measurement Of Slox-1mentioning

confidence: 99%

Section: Clinical Characteristics Of the Current Smokersmentioning

confidence: 99%

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Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Plays an Important Role in Vascular Inflammation in Current Smokers

Takanabe-Mori

Ono

Wada

et al. 2013

JAT

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“…Thus, hs-CRP might be a marker of inflammation due to oxidative stress, and an association between hs-CRP and arterial wall stiffness might be observed in the present study. Thus, the association between LDL-C and CAVI including hs-CRP remains a future topic to be investigated, especially in further combination with apolipoprotein B14 or oxidized LDL-C 23) . The present study had several limitations.…”

Section: Discussionmentioning

confidence: 99%

Does High-Sensitivity C-Reactive Protein or Low-Density Lipoprotein Cholesterol Show a Stronger Relationship with the Cardio-Ankle Vascular Index in Healthy Community Dwellers?: the KOBE Study

Higashiyama

Wakabayashi

Kubota

et al. 2012

JAT

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Aim: High-sensitivity C-reactive protein (hs-CRP) identifies individuals at risk for cardiovascular disease (CVD) without an increased level of low-density lipoprotein cholesterol (LDL-C). The present study was performed to compare hs-CRP and LDL-C in association with the cardio-ankle vascular index (CAVI) in Japanese community dwellers considered to be at low risk for atherosclerosis from their level of traditional CVD risk factors. Methods: A community-based study involving 386 healthy Japanese (261 men and 125 women) without a history of CVD and medications for hypertension, diabetes, and dyslipidemia was performed. Multiple adjustments were performed with linear regression models to estimate the association between CAVI and hs-CRP or LDL-C levels. The participants were divided into four groups on the basis of whether they were above or below the median hs-CRP and LDL-C values, and CAVI was compared among the four groups by analysis of covariance after adjusting for confounders. Results: In multiple linear regression models, hs-CRP showed a significant positive association with CAVI; however, no clear association was observed between CAVI and LDL-C. These results were similar in the analyses among the participants with LDL-C ＜140 mg/dL or hs-CRP ＜1.0 mg/L. CAVI was higher in the groups with high hs-CRP than in those with low hs-CRP, irrespective of LDL-C; however, CAVI was highest in the group with high LDL-C and high hs-CRP. Conclusions: The present study suggests that hs-CRP could be a better risk factor assessor for atherosclerosis than LDL-C in individuals considered to be at low risk for atherosclerosis assessed by their traditional CVD risk factors.

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Lectin‐like oxidized low‐density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis

Ishikawa¹,

Ito²,

Akiyoshi³

et al. 2012

Arthritis & Rheumatism

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Objective. To determine whether lectin-like oxidized low-density lipoprotein (ox-LDL) receptor 1 (LOX-1) and the soluble form of LOX-1 (sLOX-1) are novel target molecules for the diagnosis and treatment of rheumatoid arthritis (RA).Methods. Expression of ox-LDL and LOX-1 proteins in human RA synovium was evaluated by immunohistochemistry. Human RA fibroblast-like synoviocytes (FLS) were assessed for ox-LDL-induced expression of LOX-1 and ox-LDL-induced production of matrix metalloproteinase 1 (MMP-1) and MMP-3. Levels of sLOX-1 in the plasma and synovial fluid of patients with RA, compared with patients with osteoarthritis (OA), were determined by a specific chemiluminescence enzyme-linked immunoassay. In animal experiments, ox-LDL was injected into the knee joints of mice, with or without an anti-LOX-1 neutralizing antibody or sLOX-1, and the severity of arthritis was analyzed by histology and immunohistochemistry.Results. Oxidized LDL and LOX-1 proteins were detected in the RA synovial tissue. Levels of MMP-1 and MMP-3 were enhanced by stimulation of RA FLS with ox-LDL, and the production of both MMPs was inhibited by blockade of the ox-LDL-LOX-1 interaction with the anti-LOX-1 neutralizing antibody or sLOX-1. Levels of sLOX-1 in the plasma and synovial fluid of RA patients were significantly higher than those in OA patients and healthy controls and were positively correlated with inflammation markers and the extent of RA disease activity. In the knees of mice, blockade of the ox-LDL-LOX-1 interaction suppressed arthritic changes and reduced the expression of MMP-3 induced by ox-LDL.Conclusion. These findings strongly indicate that sLOX-1 is a novel biomarker that may be useful for the diagnosis of RA and for the evaluation of disease activity in RA. Furthermore, the results suggest that LOX-1 may be a potent therapeutic target for RA.

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LOX Index, a Novel Predictive Biochemical Marker for Coronary Heart Disease and Stroke

Cited by 105 publications

References 38 publications

Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Plays an Important Role in Vascular Inflammation in Current Smokers

Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Plays an Important Role in Vascular Inflammation in Current Smokers

Does High-Sensitivity C-Reactive Protein or Low-Density Lipoprotein Cholesterol Show a Stronger Relationship with the Cardio-Ankle Vascular Index in Healthy Community Dwellers?: the KOBE Study

Lectin‐like oxidized low‐density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis

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