<i>In vitro </i>and <i>in vivo </i>Virostatic Properties of Alkylated Pyrimidines Against DNA and RNA Viruses

Spectroscopic and electronic structure calculation of a potential chemotherapeutic agent 5-propyl-6-(p-tolylsulfanyl)pyrimidine-2,4(1H,3H)-dione using first principles

“…A broad set of pyrimidine drugs possesses a variety of curative properties. Several pyrimidine-based derivatives have been developed as anticancer agents [1e4], and antiviral agents against HIV [5e9], HBV [10,11], HCV [12], and HSV [13,14]. In addition, several pyrimidine derivatives have long been recognized as potent bactericidal [15e19], fungicidal [20,21] and antiprotozoal agents [22e25].…”

Pyrimidine Type Enzyme Inhibitors: I. Design of Active Pyrimidines of Virostatic Value

“…Some of the resulting compounds have been shown to exhibit in in vitro and in vivo experiments cytostatic [2] and virostatic activities [3,4], In the present communication some details of the rational used in de signing these compounds are discussed and in vitro evidence for the inhi bition of SH groups by them is produced.…”

Quantitative analysis of hydrogen and chalcogen bonds in two pyrimidine-5-carbonitrile derivatives, potential DHFR inhibitors: an integrated crystallographic and theoretical study

“…1 The chemotherapeutic potency of pyrimidine-based drugs is attributed to their inhibitory effect on the biosynthesis of vital enzymes responsible for nucleic acids such as thymidylate synthetase (TSase), thymidine phosphorylase (TPase), dihydrofolate reductase (DHFR) and reverse transcriptase (RTase). Several pyrimidine-based drugs are currently used as efficient anticancer [2][3][4][5][6] and antiviral agents against human immunodeciency viruses (HIV), [7][8][9][10] hepatitis B virus (HBV), 11,12 herpes simplex virus (HSV) 13 and SARS-CoV virus. 14 In addition, several pyrimidine-based drugs are currently used as antibacterial agents.…”