&lt;i&gt;In Vitro&lt;/i&gt; Skin Permeation and Antifungal Activity of Naftifine Microemulsions

Erdal, Meryem Sedef; Gürbüz, Aslı; Tan, Seher Birteksöz; Güngör, Sevgi; Özsoy, Yıldız

doi:10.4274/tjps.galenos.2018.87699

Cited by 10 publications

(3 citation statements)

References 28 publications

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“…With naftifine, fungal infections may be treated. Erdal et al developed a naftifine microemulsion using oleic acid (oil phase), Kolliphor EL or Kolliphor RH40, Transcutol, and water [ 117 ]. According to in vitro transdermal studies, the naftifine microemulsion significantly increased the efficiency of transdermal penetration compared with other commercially available dosage forms, and an analysis by infrared spectroscopy demonstrated the microemulsion increased the lipid bilayer’s mobility.…”

Section: Development Of the Tddsmentioning

confidence: 99%

Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System

Cheng,

Tai,

Shen

et al. 2023

Pharmaceutics

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Skin diseases are among the most prevalent non-fatal conditions worldwide. The transdermal drug delivery system (TDDS) has emerged as a promising approach for treating skin diseases, owing to its numerous advantages such as high bioavailability, low systemic toxicity, and improved patient compliance. However, the effectiveness of the TDDS is hindered by several factors, including the barrier properties of the stratum corneum, the nature of the drug and carrier, and delivery conditions. In this paper, we provide an overview of the development of the TDDS from first-generation to fourth-generation systems, highlighting the characteristics of each carrier in terms of mechanism composition, penetration method, mechanism of action, and recent preclinical studies. We further investigated the significant challenges encountered in the development of the TDDS and the crucial significance of clinical trials.

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Section: Development Of the Tddsmentioning

confidence: 99%

Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System

Cheng,

Tai,

Shen

et al. 2023

Pharmaceutics

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“…The presence of oils and surfactants in the microemulsion formulation facilitates drug permeability throughout SC 9 . In the study of Erdal et al, 36 physicochemical characterization was carried out by preparing microemulsions containing oleic acid (oil phase), Kolliphor EL or Kolliphor RH40 (surfactant), Transkutol (common surfactant) and water. C. albicans ATCC 10231 and C. parapsilosis were used to evaluate the antifungal susceptibility of naftifine loaded microemulsions.…”

Section: Microemulsionsmentioning

confidence: 99%

Innovative Drug Delivery Systems for Infectious Diseases of the Skin

Esentürk-Güzel

Kara²

2022

Univ J Pharm Res

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Introduction: Skin is the organ of the body that is exposed mostly to the microorganisms. Bacteria, fungi, and viruses are usually responsible for the infection of the skin. Due to lack of penetration through the stratum corneum of conventional systems used in infectious diseases of the skin leads to a decrease in bioavailability. For this reason, nanoscale drug delivery systems that could be used in infectious diseases of the skin are currently being investigated. Areas covered: In this review, innovative studies conducted over the years are presented. New topical formulations such as nanoparticles, microemulsions, liposomes, nanofibers and micelles etc are widely used and topic of research for many researchers. Conclusion:Studies have shown that the smaller size and control of these delivery systems provide more effective treatment by increasing drug penetration into the skin. It has been found that drug delivery systems provide a better antimicrobial effect, especially in resistant infections caused by MRSA.

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“…The fungal strain inoculum was sub-cultured into the broth medium (RPMI-1640 medium) and incubated at 25-30 °c for 48 h. The prepared suspension of fungal stain was added to the 5 ml distilled water and further diluted to match the turbidity of a 0.5 McFarland standard to achieve concentration 1×10 3 CFU/ml-5 ×10 3 CFU/ml. To achieve final concentration 1×10³CFU/ml-5 ×10³ CFU/ml by further dilution 1 in 30 by using sterile distilled water [23,24].…”

Section: Antifungal Assay Of Curcumin-loaded Microemulsionmentioning

confidence: 99%

Formulation and Development of Curcumin Based Emulgel in Treatment and Recurrence of Vaginal Candidiasis

Bairagi

Patel

2021

Int J Curr Pharm Sci

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Objective: The main causative agent of vaginal candidiasis is Candida albicans and it develops resistance against several synthetic antifungal drugs and it has a high rate of infection in women. According to WHO report, around 75% of women are infected by Candida albicans and 50 % are infected a second time by Candida albicans. Therefore, we choose Curcumin an antifungal agent that had reported antifungal properties against the various fungal species. The Curcumin-containing emulgel based microemulsion system was prepared for greater retention time and penetration across the vaginal mucosa. Methods: The screening of oil phase, surfactant, and cosurfactant for microemulsion formulation was selected based on the solubility study and followed by the construction of the pseudoternary phase diagram. The oil phase, surfactant and co-surfactant are selected from the pseudoternary phase diagram for the formulation of a stable microemulsion. The prepared Curcumin-loaded microemulsion was characterized by globule size, polydispersity index, Zeta potential, accelerated stability study, drug content, percent transmittance and antifungal assay by broth microdilution technique. The formulated microemulsion was converted into a vaginal emulgel by using Pluronic@F127. The formulated curcumin-loaded emulgel was characterized by different evaluation parameters and antifungal study by agar well diffusion method. Results: The result showed that the average globule size of emulgel was 286.3 nm, polydispersity index was 0.241, Zeta potential was+19.20 mv, conductivity was 0.0390 mS/cm, and drug content was found to be 95.58%. The texture of formulated emulgel was found to be soft and smooth, with shear-thinning, pseudoplastic behavior, and easily spreadable. The in vitro permeability study of emulgel shows slow and complete release of curcumin in 10 h. The microemulsion and developed emulgel showed promising antifungal activity against Candida albicans. Conclusion: The developed curcumin-loaded emulgel showed promising antifungal activity against Candida albicans as compared to the Fluconazole as an standard antifungal antibiotic. Our formulated Curcumin-containing emulgel can be a potential alternative as compared to the conventional dosage form for the treatment of vaginal candidiasis.

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<i>In Vitro</i> Skin Permeation and Antifungal Activity of Naftifine Microemulsions

Cited by 10 publications

References 28 publications

Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System

Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System

Innovative Drug Delivery Systems for Infectious Diseases of the Skin

Formulation and Development of Curcumin Based Emulgel in Treatment and Recurrence of Vaginal Candidiasis

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