<p>A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus</p>

Abstract

BackgroundTraditional Chinese medicine (TCM) formulations have proven to be advantageous in clinical treatment and prevention of disease. LiuWei DiHuang Pill (LWDH Pill) is a TCM that was employed to treat type 2 diabetes mellitus (T2DM). However, a holistic network pharmacology approach to understanding the active ingredients and the therapeutic mechanisms underlying T2DM has not been pursued.MethodsA network pharmacology approach including drug-likeness evaluation, oral bioavailability prediction, virtual docking, and network analysis has been used to predict the active ingredients and potential targets of LWDH Pill in the treatment of type 2 diabetes.ResultsThe comprehensive network pharmacology approach was successfully to identify 45 active ingredients in LWDH Pill. 45 active ingredients hit by 163 potential targets related to T2DM. Ten of the more highly predictive components (such as :quercetin, Kaempferol, Stigmasterol, beta-sitosterol, Kadsurenone, Diosgenin, hancinone C, Hederagenin, Garcinone B, Isofucosterol) are involved in anti-inflammatory, anti-oxidative stress, and the reduction of beta cell damage. LWDH Pill may play a role in the treatment of T2DM and its complications (atherosclerosis and nephropathy) through the AGE-RAGE signaling pathway, TNF signaling pathway, and NF-kappa B signaling pathway.ConclusionBased on a systematic network pharmacology approach, our works successfully predict the active ingredients and potential targets of LWDH Pill for application to T2DM and helps to illustrate mechanism of action on a comprehensive level. This study provides identify key genes and pathway associated with the prognosis and pathogenesis of T2DM from new insights, which also demonstrates a feasible method for the research of chemical basis and pharmacology in LWDH Pill.

A Network Pharmacology Analysis of the Active Components of the Traditional Chinese Medicine Zuojinwan in Patients with Gastric Cancer

“…Molecular docking relies on the “lock-key principle” of ligand-receptor interaction and mimics the interaction between small molecule ligands and receptor bio-macromolecules [ 32 ]. Through calculations the combination mode and affinity between the compounds and proteins can be predicted [ 33 , 34 ]. The whole molecular docking process, performed on Molecular Operating Environment (MOE) (v2015.10), includes 3 steps: receptor preparation, receptor grid generation, and docking.…”

A Network Pharmacological Approach to Investigate the Mechanism of Action of Active Ingredients of Epimedii Herba and Their Potential Targets in Treatment of Alzheimer’s Disease

“…Drug-likeness (DL) is a qualitative concept used in drug design [ 16 ]. According to the drug screening standard recommended by TCMSP [ 17 ], the active ingredient of Epimedii Herba was obtained by using the drug screening standard 20 with OB ≥30% and DL ≥0.18 [ 18 ] ( Table 1 ).…”

Elucidation of the Mechanisms and Molecular Targets of Sanhuang Xiexin Decoction for Type 2 Diabetes Mellitus Based on Network Pharmacology

“…In recent years, with the continuous deepening of understanding and research on T2DM, traditional Chinese medicines (TCMs) have played a unique advantage in treating T2DM and its chronic complications, such as Guizhi Shaoyao Zhimu decoction [4], Liuwei Dihuang Pill [5], and Shenqi Dihuang decoction [6]. Sanhuang Xiexin decoction (SXD) is a classic prescription of three traditional herbal extracts including Rheum palmatum L. (Dahuang), Scutellaria baicalensis Georgi (Huangqin), and Coptis chinensis Franch.…”