&lt;p&gt;Assessment of Diabetic Retinopathy Vascular Density Maps&lt;/p&gt;

Saif, Passant Sayed; Salman, Abd El-Rahman Gaber; Omran, Norhan Amr Hassan; Farweez, Yousra Ahmed Thabet

doi:10.2147/opth.s256963

“…Changes in A v provide information on vascular integrity 14–18 . Retinal vascular density changes as a possible biomarker have been reported in several other diseases such Alzheimer diseases, mild cognitive impairment, Fabry disease and diabetes mellitus 26–28 . Our control subjects T v ranged from approximately 1.11 to 1.15 pixel/pixel.…”

Section: Discussionmentioning

confidence: 99%

“… 14 , 15 , 16 , 17 , 18 Retinal vascular density changes as a possible biomarker have been reported in several other diseases such Alzheimer diseases, mild cognitive impairment, Fabry disease and diabetes mellitus. 26 , 27 , 28 Our control subjects T v ranged from approximately 1.11 to 1.15 pixel/pixel. Higher T v was observed in arteries (1.17 ± 0.04) and veins (1.17 ± 0.04) of PAH subjects, indicating that retinal T v in treated PAH patients may be abnormally increased.…”

Section: Discussionmentioning

confidence: 99%

Retinal vessel changes in pulmonary arterial hypertension

Dupont

¹

,

Lambert

²

,

Rodriguez-Martin

³

et al. 2022

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Pulmonary arterial hypertension (PAH) is classically considered an isolated small vessel vasculopathy of the lungs with peripheral pulmonary vascular obliteration. Systemic manifestations of PAH are increasingly acknowledged, but data remain limited. We hypothesized that retinal vascular changes occur in PAH. PAH subjects underwent retinal fluorescein angiography (FA) and routine disease severity measures were collected from the medical record. FA studies were analyzed using VESsel GENerational Analysis (VESGEN), a noninvasive, user‐interactive computer software that assigns branching generation to large and small vessels. FAs from controls (n = 8) and PAH subjects (n = 9) were compared. The tortuosity of retinal arteries was higher in PAH subjects compared to unmatched controls (1.17, 95% confidence interval: [1.14, 1.20] in PAH vs. 1.13, 95% CI: [1.12, 1.14] in controls, p = 0.01). Venous tortuosity was higher and more variable in PAH (1.17, 95% CI: [1.14, 1.20]) compared to controls (1.13, 95% CI: [1.12, 1.15]), p = 0.02. PAH subjects without connective tissue disease had the highest degree of retinal tortuosity relative to controls (arterial, p = 0.01; venous, p = 0.03). Younger PAH subjects had greater retinal arterial tortuosity, which attenuated with age and was not observed in controls. Retinal vascular parameters correlated with some clinical measures of disease in PAH subjects. In conclusion, PAH subjects exhibit higher retinal vascular tortuosity. Retinal vascular changes may track with pulmonary vascular disease progression. Use of FA and VESGEN may facilitate early, noninvasive detection of PAH.

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“…Although vascular densities have been well described in diseased eyes [18][19][20][21], there is a lack of normal values of vascular densities in healthy eyes. Such data can be useful in the early detection of retinal abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography Angiography in Healthy Adult Subjects: Normative Values, Frequency, and Impact of Artifacts

Abu-Yaghi

¹

,

Obiedat

²

,

AlNawaiseh

³

et al. 2022

BioMed Research International

2

0

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Aim. This cross-sectional study is aimed at identifying normative ocular coherence tomography angiography (OCTA) values in a cohort of healthy adult Jordanian individuals and assessing the prevalence of different image artifacts and their impact on quantitative OCTA measurements. Materials and Methods. One hundred and eighty-one eyes from 100 healthy participants were included in this study. All participants underwent a comprehensive ophthalmological examination including best corrected visual acuity, slit lamp examination, and dilated fundoscopy. Swept-source OCTA images were obtained and analyzed for all 181 eyes. We recorded vascularity measurements and analyzed the prevalence and effect of ten different artifacts on superficial and deep retinal and choriocapillaris layer images. Results. Sixty-two percent of the participants were men ( n = 62 ), and 38% ( n = 38 ) were women. The age of participants ranged between 24 and 75 years (mean 50.5 ± 10.92 ). The mean central macular thickness was 237.71 (±22.905) μm, and the mean choroidal thickness was 257.73 (±77.027) μm. Artifacts were present in 46.4% of the acquired scans. Images with artifacts had higher mean age ( p = 0.03 ), lower image quality ( p < 0.001 ), higher central vascular density ( p < 0.001 ), and lower inferior vascular density ( p < 0.001 ) compared to artifact-free tomographs. Motion artifact was the most common type, which was present in 29 (16%) of images, followed by blink artifact 18 (9.9%), and Z offset 8 (4.4%). Conclusion. OCTA artifact detection and correction remains a challenging aspect of the diagnostic and follow-up process of patients with retinal pathologies. To our knowledge, this is the first study to examine the association between OCTA outputs and artifacts in healthy eyes. We report that in this cohort of normal individuals, images with artifacts had a significantly higher central vascular density (22.62 vs. 16.60) and a lower inferior vascular density (46.09 vs. 48.81). We also found that a significant increase in central vascular density is only present in images with Z offset artifact type (49.03). Motion artifact was the most common artifact seen in our series. However, we observed no alteration in quantitative parameters in images with motion artifacts.

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“…This process could be associated with the larger extent of microaneurysms in the deep vascular plexus than those in the superficial plexus [ 22 – 25 ]. Previous studies related to retinal thickness, based on OCT, presented controversial results, such as the one where no significant difference was found in the thickness concerning both the group of patients and healthy controls, and another where there was a notable reduction in thickness present in patients suffering from diabetes without DR or those with mild NPDR when compared to the healthy population [ 26 , 27 ]. Our study does not reveal any significant difference difference in the OCTA parameters related to retina thickness between the groups.…”

Section: Discussionmentioning

confidence: 99%

The Determination of Type 2 Diabetes Mellitus’s Impact on the Density of Retinal Blood Vessels and the Choriocapillaris: Optical Coherence Tomography Angiography Study

Zlatanovic¹,

Jocić

²

,

Jakšić

³

et al. 2021

Journal of Ophthalmology

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Optical coherence tomography angiography (OCTA) was used to analyze the alterations in the density of retinal blood vessels and the choriocapillaris (VD) in patients suffering from type 2 diabetes mellitus (T2DM). One hundred sixty-six eyes of 83 patients (43 of whom were men and 40 women, with a mean age of 58.59 ± 14.04) with T2DM and without diabetic retinopathy were examined for the purpose of conducting the observational prospective study. The control group (CG) consisted of 66 eyes in 33 healthy subjects (15 male and 18 female, with a mean age of 55.12 ± 12.70). The measurement regions of vessel density (VD) included the deep capillary plexus (DCP), the superficial capillary plexus (SCP), and the choriocapillaris. The results indicate considerable differences in the VD of the DCP and SCP when comparing the control group with the study groups ( p < 0.001 ). In comparison with the control group ( p < 0.001 ), there was a statistically significant reduction in the VD of the choriocapillaris in the study group. Furthermore, patients with T2DM showed a significantly decreased VD concerning the control in different macular regions. Thickness in several macular regions in the study group significantly decreased compared to the ones in the control group. OCTA was used to gather relevant information about the vascular changes which occurred in T2DM patients, assessed through the quantitative analysis of the blood flow in the retina and choriocapillaris.

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<p>Assessment of Diabetic Retinopathy Vascular Density Maps</p>

Cited by 10 publications

References 35 publications

Retinal vessel changes in pulmonary arterial hypertension

Retinal vessel changes in pulmonary arterial hypertension

Optical Coherence Tomography Angiography in Healthy Adult Subjects: Normative Values, Frequency, and Impact of Artifacts

The Determination of Type 2 Diabetes Mellitus’s Impact on the Density of Retinal Blood Vessels and the Choriocapillaris: Optical Coherence Tomography Angiography Study

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