&lt;p&gt;Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome&lt;/p&gt;

Amin, Omar A; Abouzeid, Saleh M; Ali, Siham A; Amin, Bashir A; Alswat, Khaled

doi:10.2147/ndt.s198434

Cited by 17 publications

(16 citation statements)

References 22 publications

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“…Although Armstrong et al showed a significant relationship between lower vitamin D levels and anxiety or depression, they failed to disclose any relation between vitamin D levels and FIQ scores in FMS patients (15). In a study investigating the relationship between serotonin and vitamin D levels and disease severity in patients with fibromiyalgia, no significant relationship was found between vitamin D and disease severity,but serotonin levels were found to be statistically significantly lower in the severe disease group (35). Okumuş et al, in their study on 40 FMS patients and 40 healthy controls, observed that the patient group was significantly overweight and physically more inactive than the control group.…”

Section: Discussionmentioning

confidence: 95%

Fibromiyaljili Hastalarda D Vitamin Düzeylerinin Değerlendirilmesi ve Fonksiyonel Durum ile İlişkisi

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et al. 2022

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Aim: Fibromyalgia syndrome is a common musculoskeletal disorder, characterized by chronic widespread pain, multiple tender points, joint stiffness, and systemic symptoms without any underlying organic disease. The initial aim of the present study was to determine the vitamin D levels in patients with fibromyalgia and compare these values to those found in healthy subjects. Then, correlations between functional status, clinical severity of the disease, and vitamin D levels were assessed. Material and Methods: This case-control study included 137 female fibromyalgia patients and 109 healthy female counterparts. The severity of pain was assessed by a visual analogue scale and the functional impact was evaluated through the Fibromyalgia Impact Questionnaire in the patient group. Vitamin D levels were compared between groups, and the correlation between vitamin D levels and questionnaire scores was determined. Results: Vitamin D and parathormone levels did not differ significantly between groups (p=0.858, p=0.790 respectively). The mean Fibromyalgia Impact Questionnaire scores and the medians for the visual analogue scale did not differ significantly among vitamin D deficient, insufficient, and sufficient patients (p=0.548 , p=0.952 respectively). In addition, no significant correlation between vitamin D levels and the Fibromyalgia Impact Questionnaire score was found(Spearman’s rho=0.056, p=0.513). Conclusion: This study did not show any significant differences between the vitamin D levels of fibromyalgia patients and those of healthy subjects. Further, in fibromyalgia patients, there was no correlation between vitamin D levels and functional status or disease severity

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Section: Discussionmentioning

confidence: 95%

Fibromiyaljili Hastalarda D Vitamin Düzeylerinin Değerlendirilmesi ve Fonksiyonel Durum ile İlişkisi

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Özdolap

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et al. 2022

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“…Reduced serotonin levels have shown to be linked to vitamin D deficiency and symptom severity in FM. Brain serotonin is synthesized from tryptophan via an enzyme activated by vitamin D, and a dose-dependent negative relationship between serotonin levels and FM impact questionnaire scores has been reported [ 114 , 115 ].…”

Section: Methodsmentioning

confidence: 99%

“…The connection between vitamin D and FM has been widely studied [107][108][109][110][111][112][113][114][115][116][117][118][119][120][121]. However, the relationship between vitamin D deficiency and FM is controversial among literature.…”

Section: Vitamin D In the Treatment Of Fibromyalgiamentioning

confidence: 99%

The Role of Nutrient Supplementation in the Management of Chronic Pain in Fibromyalgia: A Narrative Review

et al. 2021

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Introduction:The multifaceted clinical presentation of fibromyalgia (FM) supports the modern understanding of the disorder as a more global condition than one simply affecting pain sensation. The main pharmacologic therapies used clinically include anti-epileptics and antidepressants. Conservative treatment options include exercise, myofascial release, psychotherapy, and nutrient supplementation. Methods: Narrative review. Results: Nutrient supplementation is a broadly investigated treatment modality as numerous deficiencies have been linked to FM. Additionally, a proposed link between gut microbiome patterns and chronic pain syndromes has led to studies investigating probiotics as a possible treatment. Despite positive results, much of the current evidence regarding this topic is of poor quality, with variable study designs, limited sample sizes, and lack of control groups. Conclusions: The etiology of FM is complex, and has shown to be multi-factorial with genetics and environmental exposures lending influence into its development. Preliminary results are promising, however, much of the existing evidence regarding diet supplementation is of poor quality. Further, more robust studies are needed to fully elucidate the potential of this alternative therapeutic option.

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“…[175][176][177] Studies of fibromyalgia patients indicate an elevated level of serotonin in myofascial tissue and platelets, while a decreased level of tryptophan and its derivatives, serotonin and kynurenine, is observed in the blood and/or brain. 94,[178][179][180][181][182][183][184] A study finds fibromyalgia patients have decreased rate of transport of tryptophan across the blood brain barrier. 172 Several studies point to a peculiar phenomenon.…”

Section: Bizarrely Wang Et Al Find a Bidirectional Association Between Fibromyalgia And Gastroesophageal Reflux Disease (Gerd)mentioning

confidence: 99%

Scoping review and interpretation of Myofascial Pain/Fibromyalgia syndrome: an attempt to assemble a medical puzzle

Plaut

2021

Preprint

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Introduction: Myofascial Pain Syndrome (MPS) is a common overlooked and underdiagnosed condition, and with significant burden. MPS is often dismissed by clinicians while patients remain in pain for years. MPS can evolve into fibromyalgia, however, effective treatments for both are lacking due to absence of a clear mechanism. Many studies focus on central sensitization. Therefore, the purpose of this scoping review is to systematically search cross-disciplinary empirical studies of MPS, focusing on mechanical aspects, and suggest an organic mechanism explaining how it might evolve into fibromyalgia. Hopefully, it will advance our understanding of this disease. Methods: Systematically searched multiple phrases in MEDLINE, EMBASE, COCHRANE, PEDro and medrXiv, majority with no time limit. Inclusion/exclusion based on title and abstract, then full text inspection. Additional literature added on relevant side topics. Review follows PRISMA-ScR guidelines. PROSPERO yet to adapt registration for scoping reviews. Findings: 734 records included. Fascia can adapt to various states by reversibly changing biomechanical and physical properties. Trigger points, tension, and pain are a hallmark of MPS. Myofibroblasts play a role in sustained myofascial tension. Tension can propagate in fascia, possibly supporting a tensegrity framework. Movement and mechanical interventions treat and prevent MPS, while living sedentarily predisposes to MPS and recurrence. Interpretation: MPS can be seen as a pathological state of imbalance in a natural process; manifesting from the inherent properties of the fascia, triggered by a disrupted biomechanical interplay. MPS might evolve into fibromyalgia through deranged myofibroblasts in connective tissue, or "fascial armoring", which may explain pain, distribution of pain, decreased pressure/pain threshold, and other phenomena eg, occasional complete resolution after surgery. Movement is an underemployed requisite in modern lifestyle. Lifestyle is linked to pain and suffering. The mechanism of needling is suggested to be more mechanical than currently thought. MPS should no longer be overlooked but solidified in the domain of common modern medicine.

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<p>Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome</p>

Cited by 17 publications

References 22 publications

Fibromiyaljili Hastalarda D Vitamin Düzeylerinin Değerlendirilmesi ve Fonksiyonel Durum ile İlişkisi

Fibromiyaljili Hastalarda D Vitamin Düzeylerinin Değerlendirilmesi ve Fonksiyonel Durum ile İlişkisi

The Role of Nutrient Supplementation in the Management of Chronic Pain in Fibromyalgia: A Narrative Review

Scoping review and interpretation of Myofascial Pain/Fibromyalgia syndrome: an attempt to assemble a medical puzzle

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