&lt;p&gt;Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles&lt;/p&gt;

Iturrioz-Rodríguez, Nerea; Correa‐Duarte, Miguel A.; Fanarraga, Mónica L.

doi:10.2147/ijn.s198848

Cited by 117 publications

(65 citation statements)

References 128 publications

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“…Mesoporous silicon-based NMs are composed of amorphous skeletons with a high pore capacity, are uniform with an adjustable pore size, and have an available functionalization and interface effect [40]. Furthermore, this kind of material has good biocompatibility, contributing to its wide application prospects in fields of biotechnology such as drug delivery [41] and gene therapy [42,43]. The discovery of MSNs has greatly promoted the development of sustained and controlled drug release field.…”

Section: Mesoporous Silica Nms (Msns)mentioning

confidence: 99%

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Feng

Zhang

et al. 2020

Part Fibre Toxicol

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Background Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. Main body We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. Conclusion In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.

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Section: Mesoporous Silica Nms (Msns)mentioning

confidence: 99%

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Feng

Zhang

et al. 2020

Part Fibre Toxicol

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“…Conclusively, with the excellent laser-induced heating properties, FS3P-A/C could be a novel promising agent for photothermal therapy. 71 Figure 6A also reveals the viability of HEK293 cells treated with NPs at different dosages. Interestingly, almost all cells were still alive at the whole range of NP concentrations, indicating that drug-loaded FS3 showed no obvious cytotoxicity toward normal cells.…”

Section: In Vitro Anticancer Efficacy Of the Various Npsmentioning

confidence: 99%

<p>Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells</p>

Tran

Giau

Shim

et al. 2020

IJN

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Background: Core-shell types of mesoporous silica nanoparticles (MSNs) with multimodal functionalities were developed for bio-imaging, controlled drug release associated with external pH, and near-infrared radiation (NIR) stimuli, and targeted and effective chemo-photothermal therapeutics. Materials and Methods: We synthesized and developed a core-shell type of mesoporous silica nanocarriers for fluorescent imaging, stimuli-responsive drug release, magnetic separation, antibody targeting, and chemo-photothermal therapeutics. Also, the biocompatibility, cellular uptake, cytotoxicity, and photothermal therapy on these FS3-based nanocarriers were systematically investigated. Results: Magnetic mesoporous silica nanoparticles was prepared by coating a Fe 3 O 4 core with a mesoporous silica shell, followed by grafting with fluorescent conjugates, so-called FS3. The resulting FM3 was preloaded with therapeutic cisplatin and coated with polydopamine layer, socalled FS3P/C. Eventually, graphene oxide-wrapped FS3P/C (FS3P-G/C) exhibited high sensitivity in the dual stimuli (pH, NIR)-responsive controlled release behavior. On the other hand, Au NPs-coated FS3P/C (FS3P-A/C) exhibited more stable release behavior, irrespective of pH changes, and exhibited much more enhanced release rate under the same NIR irradiation. Notably, FS3P-A/C showed strong NIR absorption, enabling photothermal destruction of HeLa cells by its chemo-photothermal therapeutic effects under NIR irradiation (808 nm, 1.5 W/cm 2). The selective uptake of FS3-based nanocarriers was confirmed in cancer cell lines including HeLa (American Type Culture Collection-ATCC) and SHSY5Y (ATCC 2266) by the images obtained from confocal laser scanning microscopy, flow cytometry, and transmission electron microscopy instruments. Cisplatin-free FS3-based nanocarriers revealed good cellular uptake and low cytotoxicity against cancerous HeLa and SH-SY5Y cells, but showed no obvious toxicity to normal HEK293 (ATCC 1573) cell. Conclusion: Along with the facile synthesis of FS3-based nanocarriers, the integration of all these strategies into one single unit will be a prospective candidate for biomedical applications, especially in chemo-photothermal therapeutics, targeted delivery, and stimuliresponsive controlled drug release against multiple cancer cell types.

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“…Among the different types of nanocarriers which were developed for applications in cancer diagnosis and treatment, inorganic nanoparticles (NPs) have emerged as versatile platforms for targeted cancer imaging and drug delivery due to their inherent physical properties which allow a variety of imaging modalities and their ability for surface modification with targeting ligands and/or caged therapeutic payloads. Seminal achievements were disclosed with mesoporous silica NPs, which are composed by inner pores suitable for the immobilization of molecular cargos and outside surface amenable to conjugation with imaging probes and caging molecules . Other promising strategies include the use of functionalized superparamagnetic iron oxide NPs for targeted magnetic resonance imaging, local thermal‐ablation of cancer cells triggered by an external magnetic field and controlled delivery of chemotherapeutics such as doxorubicin .…”

Section: Introductionmentioning

confidence: 99%

Photocontrolled Release of the Anticancer Drug Chlorambucil with Caged Harmonic Nanoparticles

Vuilleumier

Gaulier

Matos

et al. 2020

Helvetica Chimica Acta

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Dedicated to Philippe Renaud on the occasion of his 60th birthdayWhile chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced efficacy due to multidrug resistance and poor target accessibility. The limitations of conventional chemotherapy formulation have prompted the development of alternative nanomaterials-based strategies to achieve targeted and stimuli sensitive payload delivery to reach optimal local drug concentration at tumor sites. In this study, the anticancer drug chlorambucil (Clb) was conjugated to the surface of silica coated lithium niobate (LNO) harmonic nanoparticles (HNPs) using a photocaging tether based on coumarin-4-yl methyl derivative. Upon laser pulsed femtosecond irradiation at 790 nm, the second harmonic emission from the metal oxide core induced the efficient release of Clb, with concomitant contribution from the nonlinear absorption of the coumarin (CM)-based moiety.

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<p>Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles</p>

Cited by 117 publications

References 128 publications

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

<p>Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells</p>

Photocontrolled Release of the Anticancer Drug Chlorambucil with Caged Harmonic Nanoparticles

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