&lt;p&gt;COPD and Osteoporosis: Associated Factors in Patients Treated with Inhaled Corticosteroids&lt;/p&gt;

Özçakır, Şüheda; Sığırlı, Deniz; Ursavaş, Ahmet; Uzaslan, Esra

doi:10.2147/copd.s274728

Cited by 11 publications

(8 citation statements)

References 35 publications

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“…A variety of inflammatory factors are involved in the activation of RANKL ( Figure 1 ). Additionally, prolonged breathing disturbances led to metabolic disorders that left patients in a state of malnutrition and affected the normal remodeling function of bone tissue ( Ozcakir et al, 2020 ). Corticosteroid application in clinical treatment was also a non-negligible factor that threatens bone health.…”

Section: Discussionmentioning

confidence: 99%

Osteoporosis in Patients With Respiratory Diseases

Qiu

Zhou

2022

Front. Physiol.

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Climate change, environmental pollution, and virus epidemics have sharply increased the number of patients suffering from respiratory diseases in recent years. Prolonged periods of illness and drug use increase the occurrence of complications in these patients. Osteoporosis is the common bone metabolism disease with respiratory disturbance, which affects prognosis and increases mortality of patients. The problem of osteoporosis in patients with respiratory diseases needs more attention. In this review, we concluded the characteristics of osteoporosis in some respiratory diseases including COPD, asthma, COVID-19, tuberculosis, and lung cancer. We revealed that hypoxia was the common pathogenesis of osteoporosis secondary to respiratory diseases, with malnutrition and corticosteroid abuse driving the progression of osteoporosis. Hypoxia-induced ROS accumulation and activated HIF-1α lead to attenuated osteogenesis and enhanced osteoclastogenesis in patients with respiratory diseases. Tuberculosis and cancer also invaded bone tissue and reduced bone strength by direct infiltration. For the treatment of osteoporosis in respiratory patients, oral-optimized bisphosphonates were the best treatment modality. Vitamin D was a necessary supplement, both for calcium absorption in osteogenesis and for improvement of respiratory lesions. Reasonable adjustment of the dose and course of corticosteroids according to the etiology and condition of patients is beneficial to prevent the occurrence and development of osteoporosis. Additionally, HIF-1α was a potential target for the treatment of osteoporosis in respiratory patients, which could be activated under hypoxia condition and involved in the process of bone remodeling.

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Section: Discussionmentioning

confidence: 99%

Osteoporosis in Patients With Respiratory Diseases

Qiu

Zhou

2022

Front. Physiol.

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“…However, it has been shown that a large number of people with COPD sometimes experience respiratory symptoms, despite the chronic use of several medications [34]. Moreover, it was documented that the inhaled corticosteroids are the secondary cause of osteoporosis in elderly patients with COPD [15], which can have a negative impact on their quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…Drug treatments in these patients have the main aims of controlling symptoms, reducing the frequency of disease exacerbation, and improving patients' performance and quality of life [13,14]. However, it can be associated with serious complications such as osteoporosis [15]. erefore, the need for proper planning for the proper management of these patients is strongly felt.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Experienced Respiratory Symptoms and Health-Related Quality of Life in the Elderly with Chronic Obstructive Pulmonary Disease

Masror-Roudsary

Aghdam

Rafii

et al. 2021

Critical Care Research and Practice

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Background. Chronic obstructive pulmonary disease (COPD) is one of the diseases that usually present at an advanced age. Respiratory symptoms in patients with COPD are the most important for making treatment decisions and understanding the adverse effects on health-related quality of life (HRQoL). This study aimed to investigate HRQoL in elderly patients with COPD and examine the relationship between this in relation to respiratory symptoms experienced by them and their demographic characteristics. Methods. This is a descriptive, correlational study of elderly patients with COPD who were hospitalized in five different hospitals in an urban area of Iran. A consecutive sampling method was used. Demographic data form, the respiratory symptoms component of St. George’s Respiratory Questionnaire (SGRQ), and the Short Form 36 Health Survey Questionnaire (SF-36) were applied for data collection. Results. The patients (n = 217) reported low HRQoL, and this impairment was more observed in the physical component. There was a significant inverse relationship between the experienced respiratory symptoms and physical ( p = 0.03 ) and mental ( p < 0.001 ) components of HRQoL. Moreover, the female gender, the low level of education, the increased duration of the disease, the increased number of hospitalizations during the past year, and the use of two classes of drugs simultaneously were associated with the impaired HRQoL. Conclusion. Our findings inform healthcare providers about the negative impacts of respiratory symptoms and other related factors on the HRQoL of elderly patients with COPD. Nurses and other healthcare providers should proactively identify respiratory symptoms and design appropriate caring strategies to improve HRQoL among this group.

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“…Osteoporosis a systemic skeletal disease is one of the significant comorbidities in chronic obstructive pulmonary disease (COPD). With an aim to aim to investigate the presence of osteoporosis and the factors that influence the prevalence of osteosporosis authors conducted study at the outpatient clinics at the Departments of Physical Medicine and Rehabilitation and Pulmonary Diseases in Bursa Uludag University Hospital, a tertiary reference center, in the northwest region of Turkey in 63 COPD patients ( Ozcakir et al, 2020 ) [M]. Thirty COPD patients were on inhaled corticosteroid (ICS) and the control group had 33 patients.…”

Section: Systemic Glucocorticoids [Sed-15 906; Seda-33 841; Seda-34 653; Seda-35 719; Seda-36 604; Seda-37 492; Seda-38 425 Seda-42]mentioning

confidence: 99%